P53 and BRCA1
Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression
... monoclonal p53 (DO1), GAPDH (Santa Cruz ...E2F4, p53 (Santa Cruz Biotech.); rabbit polyclonal BRCA1, Actin, CHK1, P-H2AX (Ser139) (Cell Signaling ...
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Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer
... developed p53-MCL functional test to detect ATM carriers might overcome at least some of these ...the p53-MCL specificity for ATM in respect to the high-risk, BRCA1/2 breast/ovarian cancer ...
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P53, KI67, Brca1 and brca 2 genes over expression in paraffin embedded primary breast cancer tissues of an indigenous black population: a 5years retrospective study
... with BRCA1 germline mutation are more of negative for estrogen , progesterone and Her 2 and more likely to be positive for p53 protein compared with control in contrast to BRCA2 tumors that do not show a ...
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umi-unc-3022.pdf
... show P53 loss or mutation (Attardi, Jacks 1999, Blackburn et ...mutant p53 allele have an increased risk of developing spontaneous tumors (Donehower et ...of p53 in the mammary gland alone. While ...
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Genetic Susceptibility to Breast cancer in East Azerbaijan, Iran
... In summary, LGRs may not be found in selected regions of the CHEK2, ATM, PTEN, p53, and BRCA1 genes. The coverage size of the MLPA kit is a critical factor for similar studies to accurately detect potential ...
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The Pathology of Hereditary Breast Cancer
... between BRCA1 and BRCA2 tumours, it is not surprising that the expression of some markers is consistently associated with hormone receptors in breast cancer, such as Bcl-2 and cyclin D1, and differ between both ...
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Ataxia-telangiectasia Mutated Kinase (ATM) as a Central Regulator of Radiation-induced DNA Damage Response
... Exposure of mammalian cells to physical or chemical factors can result in DNA lesions as intermolecular cross- linking, single or double strand breaks and others (23). Double strand breaks (DSB) cause chromatin ...
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Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors
... postnatal Brca1 -ablated cerebral cortex was substantially reduced in size with regard to both cortical thickness and surface ...that Brca1 ablation did not affect cell cycle progression. Brca1 ...
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Depletion of eIF2 GTP Met-tRNA translation initiation complex up-regulates BRCA1 expression in vitro and in vivo
... of BRCA1 function leads to carcinogenesis due to genomic instability and accelerated cell proliferation, especially when associated with either loss of function of other tumor suppressor genes, such a p53 ...
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BRCA1 regulates PIG3-mediated apoptosis in a p53-dependent manner
... One hundred and forty-nine breast tumor tissue samples were deparaffinized in xylene, followed by heat- mediated antigen retrieval using citrate buffer (BioGenex Laboratories, San Ramon, CA, USA). Antibody staining was ...
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Study of Some Genetic Variants for Cancer in Women with Breast Cancer in the East Azarbaijan Region by MLPA Method
... ATM, BRCA1, P53, CHEK2, and pten genes, which led to an inherited breast cancer, leading to an early age-related ...PTEN, P53, CHEK2 genes. In the case of the BRCA1 gene, which in most other ...
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Therapy response testing of breast cancer in a 3D high-throughput perfused microfluidic platform
... that P53 is one of the most commonly mutated genes in triple negative breast cancer and the mutation status of P53 has significant biological implica- tions ...[7]. BRCA1 mutation is also frequently ...
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Distinct functions of BRCA1 and BRCA2 in double strand break repair
... the BRCA1/BACH1 complex is BARD1 ...for BRCA1-interacting proteins, both BARD1 and BRCA1 contain a conserved RING finger motif, which is often linked to either DNA binding or ubiq- uitination ...of ...
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The p53 pathway in breast cancer
... for p53. The steady-state level of p53 mRNA is lower in many breast cancers than in normal breast epithelium ...the p53 promoter has revealed the presence of several consensus-binding sites for the ...
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Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib
... Proteotoxic stress (PS) is generated in cells under a variety of conditions involving accumulation of misfolded proteins. To avoid the toxicity of unmitigated PS, cells activate the heat shock response (HSR). HSR ...
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Co expression and regulation of p53 and muc1 in human carcinomas
... Multiple myeloma is a cancer of plasma cell in which abnormal plasma cells collected in bone marrow and interfere with normal blood cell production. In this condition, abnormal plasma cells travel form tumor to several ...
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MUCOXIN ENHANCED TRANSCRIPTION AND PROTEIN EXPRESSION OF P53 IN BREAST CANCER CELL LINE T47D
... The p53 is a tumor suppressor gene that plays an important role in maintaining genomic integr- ...inducethe p53 activity [An et al., 1998]. p53 regulation activity, can be grouped into 2 mechanisms; ...
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Modulation of immortalizing properties of human papillomavirus type 16 E7 by p53 expression.
... p53 immunoprecipitations from the rare colonies of cells arising following transfection with pE7 plus ras plus wild-type p53 or Ela plus ras plus wild-type p53 show that the level of p53[r] ...
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Transgenic expression of survivin in keratinocytes counteracts UVB induced apoptosis and cooperates with loss of p53
... single p53 allele. p53-dependent apoptosis is the primary means of eliminating keratinocytes that have sustained UVB-induced DNA damage and repre- sents an important defense mechanism against skin can- cer ...
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The double benefit of Spalax p53: surviving underground hypoxia while defying lung cancer cells in vitro via autophagy and caspase-dependent cell death
... Spalax p53, in the presence or absence of a 3MA or ...type p53 or a mutated form of the human p53 (H179R), served as a positive or negative controls, ...Spalax p53, were used in each ...
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