p53 binding protein 1
Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53 binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus induced DNA damage response
... HPV16 DNA detection was performed onto the normal and HPV16 positive 3D tissues as described by Peh et al. [51]. Complete genomic plasmid HPV16 DNA probe (cloned in pBR322 vector, kindly obtained by the Karolinska ...
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Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A X during mouse preimplantation development in the absence of DNA damage
... of p53 activity in tropho- blast cells -mediated at least partially through cytoplasmic reten- tion- participates in this transition by allowing the cell to overcome cell cycle checkpoints (Cohen et ...where ...
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RECQ1 expression is upregulated in response to DNA damage and in a p53 dependent manner
... and p53 mutations are by far the most common in human cancer, including breast ...mutant p53 (p53R280K) that confers a “gain of function” including chemotherapy resistance, metabolic deregulation, and ...
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Induction of p53-Independent Apoptosis by the Adenovirus E4orf4 Protein Requires Binding to the Bα Subunit of Protein Phosphatase 2A
... E4orf4-induced p53-independent apoptosis (28, 30, 31, 52), a genetic approach was used to define the regions of E4orf4 involved in these ...PP2A binding were involved in cell ...Figure 1 shows that ...
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Elucidation the toxicity mechanism of metal oxide and carbon based nanoparticles with p53 protein using molecular docking approach
... 2009). p53 is a well-known tumor suppressor gene which acts biochemically as a transcription factor and controls the cell proliferation and apoptosis; whereas under normal, unstressed conditions, p53 ...
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Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNA- binding protein and a p53 family target, via mRNA translation
... factor 1 (HIF1), a well-defined hypoxia responsive factor, consists of two distinct subunits, HIF1 alpha (HIF1α) and HIF1β ...HIF1α protein is modified by prolyl hydroxylase and rapidly degraded through the ...
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Genetic Evidence of a Role for ATM in Functional Interaction between Human T-Cell Leukemia Virus Type 1 Tax and p53
... represses p53 activity. To explore the various hypothe- ses for Tax-p53 interaction, we first assessed the reported re- pressive activity of Tax on ...three p53-negative cell lines, HeLa, Saos-2, and ...
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Measuring Strategic Communications
... of p53, but p53 also has the ability to regulate transcription from viral ...by p53. Numerous groups have reported that wild-type p53 has an inhibitory effect on transcription from the ...
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FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus Replication in Hepatoma Cells by Regulating Tumor Suppressor p53
... with p53 and viral proteins NS5A and ...with p53 (11, 34, 35) and inhibits p53- mediated apoptosis ...with p53 and inhibits its transactivation activity in Huh 7 cells ...only p53 and ...
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Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells
... I binding to the promoter of rRNA gene, disrupts nucleolar integrity, and impairs ribosome biogenesis and polysome ...are p53 active and p53 inactive, respectively. It enhances the binding of ...
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High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation.
... suppressor p53 regulates cell proliferation and inhib- its development or survival of cancer cells ...the p53 gene are highly associated with tumorigenesis (19). The amount of p53 protein in ...
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Original Article ErbB3-binding protein 1 inhibits tumor proliferation in esophageal cancer by targeting bcl-2 and p53 gene
... ErbB3- binding protein 1 (EBP1) is the intracellular binding protein of ...bcl, p53 proteins were detected by ...of p53 protein in Eca109/EBP1 group were ...
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The Epstein-Barr Virus Immediate-Early Protein BZLF1 Regulates p53 Function through Multiple Mechanisms
... increases p53 acetylation. Acetylation of the carboxyl terminus of p53 at lysine 320 and lysine 382 enhances p53 transcriptional function ...CREB binding protein (CBP), an acetyltrans- ...
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Targeting of p300/CREB Binding Protein Coactivators by Simian Virus 40 Is Mediated through p53
... to p53 (DO-1 or pAb122) (Lab Vision); rabbit polyclonal antibody to p53 (Cell Signaling Technology); rabbit polyclonal antibody to acetyl-p53-K373 (Upstate); rabbit polyclonal anti- body to ...
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A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism
... and p53 induced apoptosis. Dominant-negative p53 (S46G) suppressed apoptosis mediated by p53 and ...the binding of TIAF1 to the N-terminal first WW domain of WWOX, as shown by the growth of ...
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The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest.
... To determine whether the ability of E6 to interact with p53 leads to a disruption of cell cycle control, mutated E6 proteins were tested for p53 binding and p53 degradation targeting in [r] ...
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A systems level approach to understanding transcriptional regulation by p53 during mammalian hibernation
... as p53 and NF-κB move in and out of the nucleus during the torpor cycle (Fleck and Carey, 2005; Allan and Storey, ...nuclear p53 protein concentration was significantly reduced by 4-fold in torpid ...
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Human erythrocyte protein 4 1 is a phosphatidylserine binding protein
... with protein 4.1 restored PS liposome binding to control ...purified protein 4.1 to PS liposomes resulted in saturable binding with the extent of binding being proportional to the ...
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Common and unique features of T antigens encoded by the polyomavirus group.
... Mutants with changes within or near a hydrophobic region of simian virus 40 large tumor antigen are defective for binding cellular protein p53.. Mutations near the carboxyl terminus of t[r] ...
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Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor
... stabilized p53 in osteosarcoma (OS) cells. p53 knockdown reduced IGF-1R/AKT/mTORC1 activation by CP, and IGF-1R inhibition reduced the accumulation of ...between p53 and the IGF-1R/AKT/mTORC1 pathway ...
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