p53 protein
Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein
... and p53. This may lead to an increased nuclear accumulation of p53 protein and marked activation of p53-mediated apoptotic cell death in the preneoplastic foci and HCC ...of p53-CRM1 ...
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Immunoexpression of P53 protein in trophoblastic diseases
... of p53 protein immunoexpression in the diagnosis of hydatidiform molar pregnancy and the differential diagnosis of its subtypes (complete and partial) from ...
7
Dual function of MDM2 and MDMX toward the tumor suppressors p53 and RB
... and p53 pathways contributes to preserving proper homeostasis within the ...suppressor p53 protein. Under normal conditions, MDM2 and MDMX inhibit p53, either via repression of its ...
10
GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner
... and p53 with different mutational status. GTSE1 regu- lates p53 function to promote breast cancer progression mainly by the following three ...type p53 was restrained by oncogene GTSE1 via ...
16
Butler_unc_0153D_17317.pdf
... . P53 – the most frequently mutated gene in breast cancer 80 – functions as a tumor suppressor and its mutation or overexpression in breast tissue may serve as an etiologic marker for DNA damage from ...specific ...
136
mdm2 mRNA Level is a Prognostic Factor in Soft Tissue Sarcoma
... type p53 allele is capable of maintaining mdm2 gene activity ...inactive p53 only might be unable to induce the expression of the MDM2 protein ...the p53-binding site) and stabilized wild type ...
10
Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo
... mutant p53 protein. The growth of tumors bearing p53 mutations was also inhibited by treatment with these two reagents in vitro and in vivo through multiple mechanisms, implying that mutant ...
19
Quantitative measurement of p53 p53 antibody interactions by quartz crystal microbalance: A modelsystem for immunochemical calibration
... of p53 and anti-p53 ...of p53 protein (human wild type), characterized by mass spectroscopy and immobilized at various concentrations on a glass ...study, p53 protein is ...
10
Measuring Strategic Communications
... of p53 are ...to p53 because of phosphorylation of p53 by ataxia telangiectasia mutated (ATM) (Kastan ...of p53 protein from mdm2 and an accumulation of p53 protein and ...
65
Impact of the Adenoviral E4 Orf3 Protein on the Activity and Posttranslational Modification of p53
... various p53 populations, we compared sequence-specific binding to DNA in vitro by the ⌬ E1B/ ⌬ Orf3 and ⌬ E1B p53 ...active p53 that accumulates in etoposide-treated cells was included in these ...
12
Rescue of nonsense mutations by amlexanox in human cells
... truncated p53 or CFTR proteins, respect- ively, it was interesting to determine whether a treat- ment with amlexanox actually rescues the lost functions in these ...full-length p53 protein in the ...
14
A systems level approach to understanding transcriptional regulation by p53 during mammalian hibernation
... as p53 and NF-κB move in and out of the nucleus during the torpor cycle (Fleck and Carey, 2005; Allan and Storey, ...nuclear p53 protein concentration was significantly reduced by 4-fold in torpid ...
10
The Epstein-Barr Virus Immediate-Early Protein BZLF1 Regulates p53 Function through Multiple Mechanisms
... The p53 gene encodes a multifunctional protein that partic- ipates in cell cycle control, programmed cell death, genomic stability, and DNA replication, transcription, and repair (42, 53, 54, ...conditions, ...
10
Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen.
... To determine whether p53 protein levels were also increased in choroid plexus tumors and to examine the association of p53 with SV40 large T antigen in these tumors, protein extracts wer[r] ...
8
MUCOXIN ENHANCED TRANSCRIPTION AND PROTEIN EXPRESSION OF P53 IN BREAST CANCER CELL LINE T47D
... for P53 assay were p53 polyclonal anti body (Rabbit IgG anti p53) from Bioss USA with dilut- ion of 1:100 in PBS with 1% ...of P53 protein in each treatment was calculated by summing ...
6
CCAAT/enhancer Binding Protein-alpha (C/EBP-alpha) is a DNA-damage Inducible p53-regulated Mediator of the G1 Checkpoint.
... phosphorylates p53, contributing to the activation (9, 13) and accumulation of p53 protein ...UVB-induced p53 accumulation as well as C/EBPα induction suggesting UVB-induced C/EBPα is ATM/ATR ...
157
Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
... of p53 mutations, leading to the expression of mutant p53 ...mutp53 protein in these morphologically normal tissues are the same as that of the mutp53 protein in tumours, we did find that ...
13
Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor
... suppressor protein p53 is a transcription factor and key regulator of the cellular response to DNA damage and ...Wild-type p53 is normally expressed at low levels and inactive due to MDM2, an E3 ...
16
Mutational Analysis of KRAS, BRAF, and TP53 Genes of Ovarian Serous Carcinomas in Korean Women
... Mutation of the TP53 gene is the most common mutation in human cancers.16 It has been suggested that p53 protein alterations due to missense mutations and loss of the p53 protein by nons[r] ...
7
TSPAN12 is overexpressed in NSCLC via p53 inhibition and promotes NSCLC cell growth in vitro and in vivo
... Notes: (A) TsPan12 protein expressions in a549 and h1299 cells with TsPan12 shrna or scrambled control shrna (mock). (B) TsPan12 mrna level in a549 and h1299 cells with TsPan12 shrna or scrambled control shrna ...
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