Pancreatic acini
Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice
... of pancreatic acinar cells, we per- formed Western blots of zymogen granule membranes puri- fied from pancreas of transgenic ...intact pancreatic acini of transgenic and wild-type ...isolated ...
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Intracellular activation of digestive zymogens in rat pancreatic acini Stimulation by high doses of cholecystokinin
... protonophore monensin (10 microM). This conversion was also inhibited by pretreatment with the serine protease inhibitor benzamidine (10 mM) but not the cysteine protease inhibitor E64 (100 microM). The results suggest ...
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Diminished agonist stimulated inositol trisphosphate generation blocks stimulus secretion coupling in mouse pancreatic acini during diet induced experimental pancreatitis
... that pancreatic acini prepared from these mice are unable to secrete amylase in response to addition of the cholinergic agonist carbachol, although they retain the ability to secrete amylase in response to ...
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Effect of Diabetes Mellitus on the Regulation of Enzyme Secretion by Isolated Rat Pancreatic Acini
... the pancreatic exocrine dysfunction in diabetes mellitus were evaluated in vitro using isolated pancreatic acini prepared from streptozotocin-induced diabetic ...diabetic acini was ...
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Enhancement of secretagogue induced phosphoinositide turnover and amylase secretion by bile acids in isolated rat pancreatic acini
... Small amounts (0.1-0.5 mM) of deoxycholate enhanced amylase secretion, which had been induced by submaximal doses of carbachol or cholecystokinin octapeptide, without affecting the maximal levels of these reactions from ...
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Volume 8 | Issue 1 - 2018
... of pancreatic sections of diabetic rats displayed loss of architecture of pancreatic acini, widening of spaces between acini, dilated interlobular duct, and congestion of blood vessels, ...
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β catenin blocks Kras dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
... in pancreatic acini (14, 15, 16), and chronic pancreatitis accelerate Kras-driven ADM/PanIN and PDA in mice ...of acini into ductal PanINs is ...that acini possessing an activating mutation in ...
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Blockade of Multidrug Resistance-Associated Proteins Aggravates Acute Pancreatitis and Blunts Atrial Natriuretic Factor’s Beneficial Effect in Rats: Role of MRP4 (ABCC4)
... In pancreatic acinar cells, se- cretin as well as other agents that in- crease cAMP have little effect on zymo- gen activation alone but sensitize the response of agents that increase intracel- lular calcium such ...
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Dominant and context specific control of endodermal organ allocation by Ptf1a
... analysis at E18.5/P0. (B,C) Morphology of control stomach, duodenum (B), extra-hepatic biliary system (EHBS; C). Closed and open arrowheads in C: cystic duct, gall bladder. (D) With Ptf1a EDD , pancreatic acinar ...
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Effects of caerulein on the apical cytoskeleton of the pancreatic acinar cell
... In this study experiments were performed to correlate the rate of digestive enzyme secretion to morphologic observations of the apical cytoskeleton using dispersed rat pancreatic acini with various ...
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Review Article On The Management Of Pancreatic Fistulae
... smaller pancreatic duct (< 3 ...main pancreatic duct along with meticulous suturing of the remnant stump, as well as covering the stump with either mesh, omentum or a sero- muscular patch can effectively ...
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Tightly controlled MRTF A activity regulates epithelial differentiation during formation of mammary acini
... protein E-cadherin in MCF10A cells. These results raise the possibility that elevated MRTF activity leads to a cel- lular dedifferentiation process, which contributes to the loss of mammary epithelial architecture. ...
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Illya E. Herasymiuk and Vira V. Maglyona
... the acini cell area increased and the acini themselves with simultaneous tendency to reduce the area of nuclei from which the nuclear cytoplasmic ratio also ...of acini did not ...
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... The present study demonstrates that herbal formulation exhibits promising antidiabetic activity and help to maintain good glycemic and metabolic control. The herbal formulation, AMT/11, elicit hypoglycaemic/antidiabetic ...
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Neurotrophic factor GDNF promotes survival of salivary stem cells
... GDNF successfully rescues SMG after radiation. We investigated whether GDNF treatment in vivo would improve saliva produc- tion in irradiated SMGs. A single dose of 50 μg GDNF was injected directly into the SMG of each ...
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The Dutch Pancreas Biobank Within the Parelsnoer Institute: A Nationwide Biobank of Pancreatic and Periampullary Diseases
... of pancreatic cancer and to describe the genome landscape of pancreatic ...The Pancreatic Cancer Research Fund Tissue Bank established in the UK is a multicenter project similar to the Dutch Pancreas ...
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Intestinal α glucosidase and some pancreatic enzymes inhibitory effect of hydroalcholic extract of Moringa stenopetala leaves
... The pancreatic α-amylase inhibition assay was per- formed according to a previous report [15]. Porcine pan- creatic α-amylase (3units/ml) was dissolved in 0.1 M phosphate buffer saline, pH 6.9. The various ...
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Evaluation of the estrogenic properties of aqueous extracts of Tragia benthamii Baker (Euphorbiaceae) and Graptophyllum pictum (Acanthaceae) and their ability to alleviate some menopausal symptoms induced by ovariectomy in Wistar rats
... This work first of all aimed to provide a scientific base for the traditional use of Tragia benthamii Baker (Acanthaceae) and Linn Graptophillum pictum (Euphorbiaceae) for the treatment of amenorrhea, dysmenorrhea and ...
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Anti-diabetic Activity of Few India Indigenous Medicinal Plants
... Diabetic control: Normal architecture with acini of serous epithelial cells along with nest of endocrine cells separated by fibrocollagenous stroma into lobules. Focal lymp[r] ...
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Practical guide to exocrine pancreatic insufficiency – Breaking the myths
... The term islet-acinar axis has been used to describe the endocrine-exocrine relationship within the pancreas, whereby there is a vascular and physiologic interaction between these different cell types [34]. ...
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