Pancreatic Beta Cell Regeneration
Stem cell approaches for diabetes: towards beta cell replacement
... the pancreatic duct epithelium could be stimulated therapeutically to make new islets ...after pancreatic injury ...the beta cell mass and reversal of ...significant regeneration comes ...
9
PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration
... for beta cell regeneration from liver ...cially pancreatic exocrine, liver, and intestinal tissues, be- cause various factors ...the regeneration ef- ficiency. Although not fully ...
7
Re expression of IGF II is important for beta cell regeneration in adult mice
... new beta cells may arise by a combination of differentiation from stem cell precursors [5,6] or by replication of existing differentiated cells ...that pancreatic-duct cells serve as a partial source ...
9
High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice
... paraffin. Pancreatic sections from mice given phosphate buffered saline alone served as ...insulin-positive beta cell: glucagon-positive cell area ratios were calculated by digitizing images ...
6
Pancreatic Beta Cell Plasticity and Involvement of Insulin- Expressing Progenitor Cells
... The ability to recover β-cell mass after STZ is age-related, with moderate regeneration after subtotal ablation in young, but not old, rodents. We (Chapter 4) and others (22,30) have shown that the ...
253
Glucose and aging control the quiescence period that follows pancreatic beta cell replication
... to beta cell ablation and GKA stimulation provide a novel insight into the mechanisms of beta cell ...of beta cell division (Cano et ...of beta cell replication ...
9
Cell therapies for pancreatic beta-cell replenishment
... of pancreatic stem/progenitor ...of beta-cell replace- ment for diabetes [15], pancreatic resident adult stem cells have been successfully differentiated into islet-like ...human ...
9
glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis
... of cell lineages via transdifferentiation is an adaptive mode of tissue regeneration and an appealing therapeutic ...of cell fate acquisition and ...insulin-secreting beta cells following ...
11
Mesenchymal stem cell therapy in type 2 diabetes mellitus
... for cell exhaustion in vivo ...the regeneration of pancreatic islet beta cells, protect endogenous pancreatic islet beta cells from apop- tosis, and ameliorate insulin resistance ...
11
The triumvirate of beta cell regeneration: solutions and bottlenecks to curing diabetes
... to beta-cell conversion in mice (Al-Hasani et ...to beta-cell conversion could counter multiple rounds of STZ-treatment mediated diabetes (Zhang et ...to beta-cell conversion was ...
13
Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
... The pancreatic b cell normally maintains a stable balance among insulin secretion, insulin production, and insulin degradation to keep optimal intracellular stores of the hor- ...rat pancreatic ...
9
The transcription factors Nkx6 1 and Nkx6 2 possess equivalent activities in promoting beta cell fate specification in Pdx1+ pancreatic progenitor cells
... in beta-cell development is a result of insufficient ...whereas beta-cells are restored after ...for beta-cell formation correlates with the peak of ...
10
Putting pancreatic cell plasticity to the test
... non-b pancreatic cells could be harnessed to become b cells has led to interest in understanding the plasticity of pancreatic ...major cell type in the pancreas, do not contribute to new b cells ...
5
The Role of OATP-Mediated Statin Transport in Pancreatic Beta Cell Function
... having been well-studied as an OATP inhibitor, it has not been widely explored as a method of mitigating OATP-mediated statin effects on insulin secretion. Abe et al. demonstrated inhibition of pravastatin uptake by ...
148
Taurine regulates insulin release from pancreatic beta cell lines
... Taurine (2-aminoethanesulfonic acid) is a sulfur-con- taining amino acid and is developmentally high in neo- nates, especially in the brain, and the levels decline to reach stable adult concentrations that are second to ...
8
CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells
... affects beta-cell function, the influ- ence of CFTR on insulin secretion was measured from isolated human and mouse pancreatic islets subjected to glucose-induced insulin secretion ...
12
Clinical significance of epithelial-mesenchymal transition
... the cell, while Ras/MAPK activity alone – without TGF-β induction - has also been linked to enhanced EMT ...of cell-cell junction complexes, mesenchymal-like tumor cells are able to invade through ...
13
The effect of cholesteryl ester transfer protein on pancreatic beta cell dysfunction in mice
... in pancreatic beta ...between cell membranes and between cell membranes and lipopro- ...of cell, thus causing free choles- terol accumulation in the ...of cell, and increase the ...
12
Effects of hemipancreatectomy on pancreatic alpha and beta cell function in healthy human donors
... sectionally were found to have significantly decreased glucose-induced phasic insulin secretion and arginine-induced insulin and glucagon secretion as compared to age, sex, and body index-matched controls. However, their ...
7
Polymorphism E23K (rs5219) in the KCNJ11 gene in Euro-Brazilian subjects with type 1 and 2 diabetes.
... Multiple genes are involved in DM (Basile et al., 2014). Those that have gained the most attention are involved in the insulin secretion pathway (Haghvirdizadeh et al., 2015). Insulin secretion is mediated through ...
9