Pancreatic beta cells
Insulin producing cells could not mimic the physiological regulation of insulin secretion performed by pancreatic beta cells
... when cells were stimulated for 30 min by low glucose concentrations, which was similar to the case observed in a non-glucose state ( P > ...both beta cells and IPCs exhibited a homogeneous ...
8
Postnatal β1 Integrin Deficiency in Pancreatic Beta-Cells Impairs Function and Survival
... positive cells as assessed by immunofluorescence staining, isolated islet protein showed no change compared to ...in beta-cells of streptozotocin and alloxan treated female mice (Kilic et ...the ...
133
Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells
... of pancreatic beta-cells located within the islets of Langerhans is essential to insure a tight control of blood glucose levels and to prevent the deleterious effects of hypo- or ...
12
Honey versus Metformin: Effects on Pancreatic Beta Cells in Streptozotocin Induced Diabetic Rats
... to pancreatic beta- cells were evaluated in streptozotocin (50 mg/kg; ...the pancreatic islets of induced diabetic rats treated by ...of beta- cells were evaluated by measuring ...
11
Opioid receptor-dependent modulation of insulin-release in pancreatic beta-cells
... alive cells in each treated well, it allows the expression of our total results as a ratio of secreted insulin/live cells at ...live cells in the non-treated wells as a baseline, we calculated the ...
10
Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids
... b cells no longer can secrete adequate insulin in response to glucose to overcome decreased insulin sensitiv- ity and ...b cells as suggested by in vitro (6–10) and in vivo (11, 12) ...
6
UPR in palmitate-treated pancreatic beta-cells is not affected by altering oxidation of the fatty acid
... the beta- ...the beta-cells ...INS cells was also observed in previous studies ...MIN6 cells and human islets compared to INS-1E cells in the presence of high glucose might be ...
8
Whole blueberry protects pancreatic beta-cells in diet-induced obese mouse
... of pancreatic β -cell mass [1, 2]. Pancreatic β -cells are essential endocrine cellular units controlling blood glucose via the biosyn- thesis and secretion of ...
9
The Hypoglycemic Action of Ketones II Evidence for a Stimulatory Feedback of Ketones on the Pancreatic Beta Cells
... The rapid increase in pancreatic-venous plasma insulin concentrations after pancreatic-arterial infusions of small amounts of ketones, coupled with the failure of similar loads of intrav[r] ...
9
Isodisomy of chromosome 6 in a newborn with methylmalonic acidemia and agenesis of pancreatic beta cells causing diabetes mellitus
... insulin-producing beta cells in otherwise normal-appearing pancreatic islets, causing insulin-dependent diabetes ...of beta cells and consequent insulin-dependent diabetes mellitus in ...
5
Induction of differentiation of undifferentiated cells into pancreatic beta cells in vertebrates
... of pancreatic differentiation (Kurisaki et ...ES cells, and production of a mammalian pancreas was successfully achieved (Nakanishi et ...ES cells were allowed to form embryoid body-like spheres ...
12
IFN gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes
... Generation of dominant-negative IFN- g receptor transgenic mice. To generate mice with beta cells resistant to IFN- g , we used a dominant negative form of the IFN- g receptor a chain. The mutant IFN- g ...
10
Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program
... b cells (12, 13), but it is unknown whether apoptosis is an underlying ...normal pancreatic b cell ...b cells in culture (14), but the action mechanism of these survival fac- tors has not been ...
8
“An Overview on Medicinal Plants with Antidiabetic Potential” by MD. Gulshan, N. Rama Rao, India.
... from pancreatic beta–cells of islets of langerhans and the animal models used for testing antidiabetic activity are mostly alloxan and streptozotocin induced ...
8
Original Article Genomic and morphoproteomic correlates implicate the IGF-1/mTOR/Akt pathway in the pathogenesis of diffuse congenital hyperinsulinism
... annels, pancreatic beta cell proliferation has been suggested to play a role in the pathogen- esis of diffuse ...of pancreatic beta cells [8, ...islet cells as a histogenetic ...
15
The Benefcial Effects of Tea on Bodily Systems: Good or Bad?
... protecting pancreatic beta cells in diabetic mice while human epidemiological studies show contradictory results about the relation between consuming tea and the risk of developing type 2 ...
10
Level of mRNA Insulin Gene and Blood Glucose STZ-Induced Diabetic Rat are Improved by Glucomannan of Amorphophallus muelleri Blume from East Java Forest Indonesia
... the pancreatic beta-cells and hepatocyte cells of PI3- K expression of STZ-induced diabetic rat provide by a glucomannan fiber of ...normal pancreatic β-cells re- generation in ...
8
MINOCYCLINE DECREASES ACETYLCHOLINESTRASE ACTIVITY IN INTRA CEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATS
... on pancreatic β ...damaging pancreatic beta cells possibly through the generation of ROS 7 intracerebroventricular (ICV) injection of streptozotocin (STZ) in rats leads to long-term and ...
6
Pancreatic islet production of murine interleukin 10 does not inhibit immune mediated tissue destruction
... adult pancreatic islets from transgenic mice expressing IL-10 in pancreatic beta cells (Ins-IL-10 mice) were grafted across the MHC barrier to examine if IL-10 could inhibit allograft ...in ...
8
VARIANTS OF ORAL GLUCOSE TOLERANCE TEST (OGTT) CURVE IN GESTATIONAL DIABETES MELLITUS (GDM)
... GDM is a state of insulin resistance and these patients can maintain normal glucose tolerance if their pancreatic beta cells secrete enough insulin to overcome this defect as occurs in impaired ...
5