pancreatic β-cell line
Coenzyme Q10 suppresses apoptosis of mouse pancreatic β-cell line MIN6
... of β‑cells caused by mitochondrial stress plays an important role in impaired insulin ...on pancreatic β‑cells against mitochondrial stress using mouse pancreatic β‑cell ...
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Development of a conditionally immortalized human pancreatic β cell line
... and β cells (23, 24) and primate hepatic progenitor cell lines ...first β cell line developed with this approach rapidly lost insulin expression ...ond line, NAKT-15, reported in ...
13
A genetically engineered human pancreatic β cell line exhibiting glucose inducible insulin secretion
... and cell transplantation reversed chemically induced diabetes in ...for cell replacement therapy in ...human cell lines when the cell type–specific promoter is ...
10
Original Article Pyruvate kinase, muscle isoform 2 promotes proliferation and insulin secretion of pancreatic β-cells via activating Wnt/CTNNB1 signaling
... of pancreatic β-cells is closely associated with type 2 diabetes mellitus (T2DM), an intractable disease affecting numerous ...in pancreatic β-cells. Mouse pancreatic ...
8
Combined modulation of polycomb and trithorax genes rejuvenates β cell replication
... Inducible β cell–specific Ezh2 expression in vivo promotes β cell replica- ...islet β cells decline with advancing age in mice and humans (19, ...constrain β cell ...
11
Xenotropic retrovirus Bxv1 in human pancreatic β cell lines
... To test whether Bxv1 is present in SCID mice used for xeno- transplantation and determine whether EndoC-βH1/2 cells contain a complete proviral genome, we selected PCR primers to amplify the Bxv1 genome. The 8 ...
6
The supply chain of human pancreatic β cell lines
... this line expressed low levels of insu- lin (INS) and was unstable, with INS expression decreasing even further with passages, which explains why it was not frequently used by the scientific ...human β ...
11
Neuronatin regulates pancreatic β cell insulin content and secretion
... clonal pancreatic β cells in our proteomic approach to avoid issues of cellular het- erogeneity from whole pancreatic ...insulinoma-derived β cell line (24), were incubated with ...
14
Original Article Response gene to complement-32 mediates TGF-β-induced epithelial-mesenchymal transition via Erk-/p38-MAPK signaling pathways in human pancreatic cancer cell line BxPC-3
... Response gene to complement 32 (RGC-32), a gene first cloned by Badea et al. in 1998, was induced by complement involving in cell cycle activation [16]. RGC-32 can be found compre- hensively in heart, brain, ...
9
Pancreatic β- and α-cell adaptation in response to metabolic changes
... rodent-derived cell lines, platforms were used in which ATP-levels were used as a proxy indicator for islet function (12), insulin protein content (6) or insulin gene expression ...a cell line ...
145
Impaired pancreatic growth, β cell mass, and β cell function in E2F1 –/– mice
... postnatal pancreatic growth by controlling the proliferation rate of pancre- atic cells (Figure 5), and it directly controls β cell function through its regulatory role on genes such as PDX1 (Figure ...
9
Regeneration of the pancreatic β cell
... ES cell lines is already a reality (41, 43, ...cloning, cell lines able to be dif- ferentiated toward cells with the phenotype of a β cell and in sufficient numbers to satisfy the needs of the ...
9
Luminescent ruthenium(II) polypyridyl complexes acted as radiosensitizer for pancreatic cancer by enhancing radiation-induced DNA damage
... the cell uptake process of ruthenium(II) complex, PANC 1 cells were treated with Ru-SR3# for 3 h and 6 h and monitored using a time-resolved fluorescence ...the cell cytoplasm, and a small portion of ...
11
Characterization of novel carcinoma cell lines for the analysis of therapeutical strategies fighting pancreatic cancer
... these cell lines can be used in a syngeneic orthotopic pancreas carcinoma model, these cells were injected into the pancreas head of C57BL/6J mice on day 0 and the pancreata were analyzed during the early phase ...
10
Extracellular Signals and Pancreatic β-cell Development: A Brief Review
... of pancreatic islet cells by autoreactive T ...precursor cell proliferation and differentiation into fully functional insulin-secreting ...pancreas cell lineage development is independent of ...
8
Epigenomic plasticity enables human pancreatic α to β cell reprogramming
... Insulin-secreting β cells and glucagon-secreting α cells maintain physiological blood glucose levels, and their malfunction drives diabetes ...human pancreatic α, β, and exocrine ...and β ...
11
Lessons in human biology from a monogenic pancreatic β cell disease
... Deciphering the complexities of human b cell physiology is critical to our understanding of the pathophysiology behind both type 1 and type 2 diabetes. One way to do this is to study individuals with congenital ...
6
The long non coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer
... Studies on human genomes have demonstrated that non-coding RNAs (ncRNAs), which do not encode pro- teins, account for more than 90% of the transcriptome [9]. The functions of a number of ncRNAs have been characterized, ...
16
Biochemical And Functional Studies Of Histone Deacetylase 3 In Metabolic Tissues
... Total pancreatic insulin and glucagon content were determined by radioimmunoassay (RIA) in which acid-ethanol extractions were performed on whole pancreata (EMD ...
136
Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration
... that pancreatic acinar cells can serve as progenitors for pancreatic islets, a concept with substantial implications for therapeutic efforts to increase insulin- producing b cell mass in patients ...
8