pancreatic β cells
The protective effect of peroxiredoxin II on oxidative stress induced apoptosis in pancreatic β-cells
... MIN6 β -cell line with proinflammatory cytokines, palmitic acid or streptozotocin dose- or time-dependently increased apoptosis, which was associated with reduced endogenous expression levels of ...stimuli-induced ...
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Memantine has no effect on KATP channels in pancreatic β cells
... further supported by the fact that dextromethorphan, a noble NMDA receptor inhibitor, showed insulin secre- tion promoting action and blood glucose lowering effect in db/db mice and type 2 diabetes patients [31, 34]. ...
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Generation of pancreatic β cells for treatment of diabetes: advances and challenges
... iPSC-derived pancreatic β cells under xeno-free condi- ...insulin-expressing cells generated from hESC/iPSC in vitro lack the proper- ties of mature pancreatic β ...islet-like ...
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HISTOCHEMCAL AND BIOCHEMICAL EFFECTS OF MELATONIN ON PANCREATIC β-CELLS OF STREPTOZOTOCIN-TREATED DIABETIC RATS
... specific pancreatic β-cell toxin, and it can be used to induce experimental diabetes mellitus in mice, rats and other laboratory, experimental ...by pancreatic β-cells through the ...
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Connexins protect mouse pancreatic β cells against apoptosis
... of β cells and their insulin ...rodent β cells in vivo (27, 32, 37, ...decreases β cell mass in both type 1 and type 2 diabetes (1, ...to pancreatic β cells, ...
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LIM domain–binding 1 maintains the terminally differentiated state of pancreatic β cells
... maintain β cell ...of pancreatic β cells. Inducible ablation of LDB1 in mature β cells impaired insulin secretion and glucose ...LDB1-depleted β cells revealed the ...
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Proproliferative and antiapoptotic action of exogenously introduced YAP in pancreatic β cells
... adult β cell in normal and disease ...of pancreatic β cell apoptosis and dysfunction in human and rodent β cells in vitro as well as in diabetic animal models in vivo (28, ...of ...
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Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor
... in β cells (64), while tyrosine kinase inhibitors apparently prevent insulin secretion in response to several secretagogues ...in β cells (66–68), which develop a defect similar to that ...
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DNA methylation directs functional maturation of pancreatic β cells
... analysis, β galac- tosidase staining, and ...in pancreatic sections (64). Briefly, pancreatic tissue was dissected in PBS, fixed in 4% formaldehyde for 4 hours to overnight, dehydrated in grades of ...
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Upregulation of insulin receptor substrate 2 in pancreatic β cells prevents diabetes
... autoimmune-mediated β cell destruction (type 1), or insufficient compensation for peripheral insulin resistance (type 2) ...tional β cells that secrete sufficient insulin quickly enough to maintain ...
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Junctional communication of pancreatic β cells contributes to the control of insulin secretion and glucose tolerance
... to β-cell modula- tion under the physiological conditions that prevail in ...of β-cell dysfunctions ...key β-cell proteins, such as insulin, GLUT2, and ...
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Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice
... of pancreatic β cells is the adequate synthesis and release of insulin in response to ...the cells induce insulin biosynthesis in response to ...stimulated β cells, whereas ...
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Frataxin deficiency in pancreatic islets causes diabetes due to loss of β cell mass
... while it is paralleled by increased apoptosis and decreased proliferation. Hence it appears feasible that ROS formation in islets from frataxin knockout ani- mals might be responsible for reduction of islet mass, number, ...
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Fundamental Elucidation of HLA in Type 1 Diabetes of Arab Populations
... Abstract: Aims/Hypothesis): Type 1 diabetes is an immune-mediated disease with destruction of the pancreatic β-cells, a process that is conditioned by multiple genes and other factors. HLA counts as ...
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ANTIDIABETIC AND ANTIDYSLIPIDEMIC PROPERTIES OF GOA-111, A MIXTURE OF GYMNEMA SYLVESTRAE, OCIMUM SANCTUM AND AZADIRACHTA INDICA EXTRACT IN THE RATIO OF 1:1:1 STUDIED IN HIGH FAT DIET FED- LOW DOSE STREPTOZOTOCIN INDUCED EXPERIMENTAL TYPE 2 DIABETES IN RAT
... Diabetes mellitus emerges from multiple biochemical and cellular impairments, including decreased insulin secretion from the pancreatic β- cells and impaired insulin action in peripheral tissues. The ...
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Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation
... of pancreatic β cells from fixative-perfused ...ashen β cells (data not shown, but see Figure 6A), except that the average diame- ter was slightly decreased (298 ± 7 nm in ashen ...
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Effects of unaltered and bioconverted mulberry leaf extracts on cellular glucose uptake and antidiabetic action in animals
... HIT-T15 pancreatic β -cells, MLE did not show any stimulating effect ...muscle cells and adipocytes, as well as insulin secretion in pancreatic β ...these cells (In vitro ...
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The source of circulating selenoprotein S and its association with type 2 diabetes mellitus and atherosclerosis: a preliminary study
... H4IIE cells reduced basal and insulin-stimulated glucose uptake, glycogen synthesis and glycogen content in vitro ...muscle cells and 3T3-L1 adipocytes was inhibited by glucose and insulin in a dose- ...
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Role of Bone Marrow-Derived Mesenchymal Stem Cells Differentiate into β Cells in the Pancreatic Microenvironment
... stem cells is controlled by their intrinsic genetic program and surrounding microenvironment, which determines the fate of adult stem cells ...of pancreatic β- cell; (2) the micro-environment ...
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Coenzyme Q10 suppresses apoptosis of mouse pancreatic β-cell line MIN6
... of β‑cells caused by mitochondrial stress plays an important role in impaired insulin ...on pancreatic β‑cells against mitochondrial stress using mouse pancreatic β‑cell ...
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