Paraoxonase 1 (PON1) gene and polymorphisms
Relationship between Paraoxonase 1 (PON1) gene polymorphisms and susceptibility of stroke: a meta-analysis
... of paraoxonase 1 (PON1) were implicated in stroke susceptibility in several case–control association ...common polymorphisms (L55M and Q192R) in the coding region of PON1 gene and the risk of ...
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Two common nonsynonymous paraoxonase 1 (PON1) gene polymorphisms and brain astrocytoma and meningioma
... some polymorphisms of pesti- cide metabolism genes failed to identify a significant interaction of exposure with the nonsynonymous PON1 polymorphisms analyzed in the present study ...PON1 ...
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Effect of cigarette smoking on paraoxonase 1 activity according to PON1 L55M and PON1 Q192R gene polymorphisms
... to play an important role in lipid metabolism. PON1 sig- nificantly decreases lipid peroxidase generation during LDL oxidation in the presence of HDL modification by lipid peroxidase [16, 17]. Smoking impairs PON1 ...
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Human Serum Paraoxonase (PON-1) and hemochromatosis gene (HFE) gene polymorphisms in occupationally exposed lead workers from Saudi Arabia
... Pharmacogenetic studies of subjects exposed to heavy metals help to evaluate the genetic susceptibility of subjects and devise appropriate treatment regimen (Ingelman- Sundberg, 2001). We evaluated the association of ...
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Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response
... inhibition by clopidogrel and decreased plasma exposure to active thiol metabolite after a clopidogrel 600 mg loading dose. Also, PON1 QQ192 genotype was associated with an odds ratio of 3.3 for the occurrence of stent ...
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Paraoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance
... Genetics of PON1 The human PON1 gene is a member of a multigene fam- ily consisting of three members in total. PON1, PON2 and PON3 are located next to each other on chromosome 7 and share extensive structural ...
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Effects of paraoxonase activity and gene polymorphism on coronary vasomotion
... Owing to the need of a better understanding of ather- osclerosis development and protective factors, the role of HDL has been extensively studied and is known as one of the strongest protectors against coronary artery ...
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Activity of paraoxonase 1 in premalignant lesion of the cervix
... On the other hand, arylesterase activity of PON1 as well as activity standardized on the concentration of HDL and apoAI was significantly reduced in CIN group, and in the subgroups with low grade and high grade changes. ...
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PARAOXONASE ACTIVITY AND PON1 (Q/R192) GENE POLYMORPHISM IN ISCHEMIC STROKE PATIENTS
... nucleotide polymorphisms (SNPs) in the coding (192Q/R and 55L/M) region of the ...PON1 gene, a glutamine to arginine substitution at amino acid 192 (Q192R) affects PON1 activity (Li et ...its gene ...
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Original Article Risk association of polycystic ovary syndrome with paraoxonase 1 and TNF-α gene polymorphisms: a meta-analysis
... In this current meta-analysis, there are some limitations and shortages. First of all, the num- ber of study and the sample sizes were not large enough for each gene polymorphism, which may not have sufficient ...
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Paraoxonase polymorphism Met Leu54 is associated with modified serum concentrations of the enzyme A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes
... A linkage disequilibrium ( P , 0.0001) was apparent be- tween the mutations giving rise to leucine and arginine at positions 54 and 191, respectively. The study underlines that susceptibility to CVD corre- lates with ...
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Enzymatic and genetic polymorphisms of paraoxonase-1 in the Gabonese population: the relation to lipid parameters in patients with diabetes
... type 1 diabetes, acute or chronic renal disease, who had had a stroke or coronary event in the last three months and who were taking lipid-lowering drugs, or estrogen or progesterone were excluded from the study, ...
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Paraoxonase 1 Gene Polymorphism (rs662) and Increased Risk of Idiopathic Foetal Growth Restriction
... Gene Expression The variation in PON1 expression in the study subjects was estimated by measuring the mRNA levels. The levels between cases and controls were compared for materno-foetal dyads. A decrease in ...
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Paraoxonase 1 in patients with diabetes mellitus
... 37 U studiji provedenoj od strane Valabhjia i sur. postavljena je slična hipoteza da su kvalitativne promjene HDL kolesterola u krvi povezane sa sniženom aktivnošću serumske PON1 te da takve promjene utječu na debljinu ...
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Regulatory regions of the paraoxonase 1 ( PON1 ) gene are associated with neovascular age-related macular degeneration (AMD)
... on gene expression, we designed experiments to test whether different PON1 5′ UTR haplotypes influence luciferase reporter gene ex- pression in cell ...on gene expression are likely to occur, we ...
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IRF5 gene polymorphisms in melanoma
... As a theoretical limitation of this study, we refrained from genotyping the melanoma metastases with the as- sumption that polymorphisms of the germline were suf- ficiently representative. Due to the genetic ...
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DVWA gene polymorphisms and osteoarthritis
... Summing up, DVWA gene was recently related to OA through a genome wide association study in the Japanese population. Today, a very limited number of reports have clarified its molecular role on cartilage ...
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Paraoxonase Gene Polymorphism and Chlamydia pneumoniae Infection in Ischemic Vascular Disease.
... causing gene by the development of modern techniques of molecular ...a gene for polymorphism: (a) to implicate the gene as a cause of a particular disease and (b) to identify as many mutant allele as ...
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Association of endothelin-1 gene polymorphisms with essential hypertension in a Chinese population.
... two polymorphisms between healthy controls and hypertension ...two polymorphisms do not play a major role in hypertension development in the Chinese ...
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The role of MMP-1 and FGFR4-R388 gene polymorphisms in pituitary adenoma
... MMP-1 gene promoter generates a new 5 ′ -GGA-3 ′ sequence that matches the core recognition sequence of the binding site for mem- bers of the Ets family of transcription factors (11, ...
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