PD-1 Inhibitor
Response to single agent PD-1 inhibitor after progression on previous PD-1/PD-L1 inhibitors: a case series
... to PD-1 or PD-L1 inhibitors, there may be situations where re-treatment has plausible ...with PD-1 blockade may be especially effective in patients who discontinue the first ...
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<p>The Combined Use of Chemotherapy and Radiotherapy with PD-1 Inhibitor, Pembrolizumab, in Advanced Cervical Cancer: A Case Report</p>
... Abstract: As a result of the limited therapeutic options, advanced cervical cancer is dif fi cult to treat, making the prognosis poor. Therefore, new therapeutic modalities or combinations need to be explored. We herein ...
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<p>Combining PD-1 Inhibitor Nivolumab with Radiotherapy Successfully Treated a Patient with Refractory Primary Mediastinal Large B-Cell Lymphoma: A Case Report and Literature Review</p>
... The combination of radiotherapy and immunotherapy is under intensive investigation in patients with solid cancers. It is believed that radiation has immunomodulatory effects. Radiation-induced DNA damage can induce the ...
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<p>Effect of PD-1 inhibitor on exhaled nitric oxide and pulmonary function in non-small cell lung cancer patients with and without COPD</p>
... In practice, as non-invasive methods for assessing lung in fl ammation and pulmonary function, spirometry and fraction of exhaled nitric oxide (FeNO) are widely used. The levels of FeNO surrogate type2 airway in fl ...
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<p>Safety and Efficacy of PD-1 Inhibitors Plus Chemotherapy in Advanced Soft Tissue Sarcomas: A Retrospective Study</p>
... the PD-1 inhibitor pembrolizumab for the treatment of patients with advanced STS and bone sarcomas, the objective response rate (ORR) of patients with STS was only 18% (7 out of 40 ...(a ...
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Risk of hematologic toxicities with programmed cell death-1 inhibitors in cancer patients: a meta-analysis of current studies
... from PD-1 inhibitors have not adequately ...on PD-1 inhibitor-related hematologic ...during PD-1 inhibitor monotherapy (Figure ...of PD-1 ...
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Clinical and immunologic correlates of response to PD-1 blockade in a patient with metastatic renal medullary carcinoma
... Here, we report the first case of immune microenviron- ment profiling and response to anti-PD-1 in a patient with RMC to our knowledge. RMC is a rare subtype of kidney cancer most commonly diagnosed at ...
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<p>Efficacy and safety of programmed death 1 inhibitors in patients with advanced non-small cell lung cancer: a meta-analysis</p>
... the PD-1 pathway can theoretically restore the immune killing effect of T cells in the tumor microenviron- ment and successfully inhibit ...against PD-1 (nivolumab and pembrolizumab) have been ...
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Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study
... observed with ipilimumab and PD-1 inhibitor monother- apy [6–9, 23–26]. Considering the data available so far, we conclude that the increase of ORR of the combined blockade versus PD-1 ...
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<p>Risk and incidence of fatal adverse events associated with immune checkpoint inhibitors: a systematic review and meta-analysis</p>
... Figure 1, we identified a total of 12 clinical ...CTLA-4 inhibitor (ipilimumab, n = 10), and four trials evaluated PD-1 inhibitor (nivolumab, n = 3; pembrolizumab, n = ...no ...
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Evidence from a meta-analysis: is nivolumab neurotoxic in cancer patients?
... death 1 (PD-1) inhibitor nivolumab versus other chemotherapy or immunotherapy ...the PD-1 inhibitor nivolumab did not cause increased or decreased risks of fatigue, ...
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PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers
... protein 1 (PD-1) or its ligand (PD-L1) can reverse immune tolerance and yield remarkable clinical responses for a subset of patients with ...checkpoint inhibitor (ICI) therapy have the ...
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Thyroid abnormalities following the use of cytotoxic T-lymphocyte antigen-4 and programmed death receptor protein-1 inhibitors in the treatment of melanoma.
... a PD-1 inhibitor or ipilimumab or a combination of nivolumab with ipilimumab for melanoma and developed hyperthyroidism, all investigated with thyroid uptake ...
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Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade
... for PD-L1 and PD-1 immunohistochemistry (IHC). PD-L1 expression was assessed using the murine anti-human PD-L1 monoclonal antibody 5H1 (from Lieping Chen, Yale University, New Haven, ...
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Orchestration of immune checkpoints in tumor immune contexture and their prognostic significance in esophageal squamous cell carcinoma
... of PD-L1 in primary ESCC were associated with a poor clinical ...of PD-L2. PD-L2 seems to be expressed in a higher proportion of tumors ...than PD-L1 (53.9%), and PD-L2 expression is ...
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<p>Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development</p>
... a PD-L1 inhibitor prolonged survival in tumor-bearing mice, increased CD8 + T cell in fi ltra- tion, and decreased TAM in fi ltration by histological and fl ow cytometric ...
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Drug response to PD-1/PD-L1 blockade: based on biomarkers
... ligand 1 (PD-L1) have provided great hopes for patients with ...anti- PD-1/PD-L1 therapy includes not only the elimination of immunosuppressive tumor cells but also the rejuvenation of ...
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PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse
... of PD-1/PD-L1/PD-L2 in osteosarcoma, chondrosarcoma, synovial sarcoma, and ...of PD-1, PD-L1, and PD-L2 may indicate the underlying basis for the different ...
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MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment
... MDM2 inhibitor NVP-HDM201 treatment in murine tumors as well as tumor draining lymph nodes, leading to synergistic effect of NVP- HDM201 in combination with anti-PD-1 or PD-L1 antibody in ...
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The adsorption structure of furan on Pd(1 1 1)
... have applied is to assume that the only symmetry element that can be common to both the molecule and the substrate, namely a mirror plane perpendicular to the surface, is present in the adsorption structure. This ...
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