PDZ domain
Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C Terminal Processing Proteases
... the PDZ domain maintains critical contact with helix ␣ 3 by the sensor Arg168 ...the PDZ domain of Prc does not interact with helix h9 in the resting ...exposed PDZ ligand-binding ...
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Original Article Identification of potential PDZ-domain proteins downstream of ephrinB2 reverse signaling during osteoclast differentiation of RAW264.7 cells
... of PDZ domains is to regulate subcellular targeting of proteins, espe- cially membrane proteins, and also to serve as protein scaffolds for assembly of multimeric protein ...(with PDZ domains that are ...
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Role of the PDZ Domain-Binding Motif of the Oncoprotein E6 in the Pathogenesis of Human Papillomavirus Type 31
... the PDZ domain-binding motif of E6 in the pathogenesis of HPV31, we constructed two mutant viral genomes in which the PDZ domain-binding motif of E6 was altered ...entire PDZ ...
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A Novel PDZ Domain Interaction Mediates the Binding between Human Papillomavirus 16 L2 and Sorting Nexin 27 and Modulates Virion Trafficking
... PX domain with phosphatidylinositol-3-monophosphate groups (PtdIns 3P) ...amino-terminal PDZ domain that allows it to target a subset of other proteins that SNX17 cannot ...Bin/Amphyphysin/Rvs ...
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The PDZ Domain of PICK1 Differentially Accepts Protein Kinase C α and GluR2 as Interacting Ligands
... —The PDZ domain of PICK1 has the capacity to accept several dif- ferent PDZ binding motifs as recently described by GST pull- down studies (33) and as predicted by computer modeling ...) PDZ ...
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PDZ domain binding motif of human T cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T cell line
... the PDZ domain-binding motif (PBM) located at the Tax1 C-termi- nus, S/TXV (S/T, serine or threonine; X, any amino acid; V, valine), is responsible for the high CFSA activity relative to Tax2 ...to ...
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Regulation of CRFR1 and 5-HT2AR by PDZ Domain-Containing Proteins SAP97 and PSD-95
... 1.4). PDZ domains are approximately 80-90 amino acid residues in length and are the most common protein-protein interaction domain (Doyle et ...unique PDZ domain sequences, they all contain a ...
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Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins
... 7). PDZ domain-con- taining proteins represent a diverse family of polypeptides that contain single or multiple PDZ domains, other types of pro- tein-protein interaction modules including SH3, WW, ...
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The PDZ domain protein Mcc is a novel effector of non canonical Wnt signaling during convergence and extension in zebrafish
... the PDZ protein Scrib (Belotti et ...non-canonical PDZ interaction motif that involves (at least) serine 464, which is mutated to asparagine (S464N) in the classic Loop- tail mouse (Kibar et ...of ...
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Molecular design of orthogonal stacking system at the complex interface of HtrA PDZ domain with its peptide ligands
... The synergistic effect can also be found in the binding of peptide ligand to HtrA PDZ domain. The change of total binding Gibbs energies, ΔG, of wild-type C3H1 peptide and its two single-point mutations ...
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Molecular characterization and ligand binding specificity of the PDZ domain containing protein GIPC3 from Schistosoma japonicum
... SjGIPC3-PDZ domain or full- length SjGIPC3 were used as bait, analogous binding specificities can be deduced from the unique C-terminal tails obtained from both Y2H ...the PDZ domain to some ...
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Comparison of p53 and the PDZ domain containing protein MAGI 3 regulation by the E6 protein from high risk human papillomaviruses
... It is clear that E6 proteins from high-risk HPV types medi- ate the degradation of both p53 and several PDZ domain- containing proteins, including MAGI-3. However, since these cellular proteins perform ...
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The PDZ domain of the SpoIVB serine peptidase facilitates multiple functions
... SpoIVB PDZ domain. (A) Schematic diagram showing the position of the PDZ domain of SpoIVB (residues 102 to ...peptidase domain, and a region thought to be involved in SpoIVB’s putative ...
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PICK1 regulates the trafficking of ASIC1a and acidotoxicity in a BAR domain lipid binding-dependent manner
... mechanism of PICK1-mediated protein trafficking is not clear at this moment. One model which could reconcile these differences is that PICK1 may maintain an intra- cellular reserve pool of membrane proteins. This pool of ...
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Role of Tat Mediated PDZ Peptide Delivery in Pain Therapy
... of PDZ domains comprises six β strands (βA-βF) and two α helices (αA and ...cognate PDZ domain, although residues at the –1 and –3 positions and those further upstream also contribute to the ...
5
Distinct functions of HTLV 1 Tax1 from HTLV 2 Tax2 contribute key roles to viral pathogenesis
... cell growth promoting cytokines in vivo, but HTLV-1 infected cells under conditions of low cytokines can grow much more efficiently than HTLV-2-infected cells. Such growth advantage of HTLV-1 infection would cause more ...
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NHE3 regulatory complexes
... cytoplasmic domain, which acts as a scaffold to bind multiple regulatory proteins and links NHE3 to the ...multi-PDZ domain containing proteins NHERF1 and ...the domain structure of NHE3 and ...
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Interactions of native peptides and small molecules with the PDZ domains of PSD-95 and SAP97
... previous PDZ domain inhibition research is that of chemically modified peptides, such as the chemically modified peptide designed to target the GIPC PDZ domain (Patra et ...GIPC ...
347
Genetic analysis of odor-guided behavior in Drosophila melanogaster
... of PDZ proteins called LAP proteins have been identified in the worm (Legouis et ...binding domain comprising 16 leucine-rich repeats (hence, LAP stands for Leucine-rich repeats And PDZ) located at ...
169
PDZ Protein Regulation of β-arrestin Recruitment and GPCR Trafficking
... than PDZ-ligand binding, therefore influencing the specific make up of protein complexes (Chang et ...the PDZ domain of shank1 and GRIP1 PDZ6 form back-to-back homodimers through interactions between ...
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