peptide inhibitors
The influence of dietary peptide inhibitors of angiotensin-converting enzyme on the hypotensive effects of enalapril
... Hypertension can be treated using lifestyle measures, such as increasing physical activity, maintaining a normal body weight, and adopting a healthy diet. In addition, bor- derline hypertensive subjects can ingest FOSHU ...
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Mutations of Glu560 within HIV 1 Envelope Glycoprotein N terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry
... To investigate the property and resistance mecha- nisms of these substitutions at position 560 in HR1, we constructed HIV-1 LAI pseudoviruses bearing Env with mutations E560K/D/G. The mutation E560K conferred resistance ...
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Peptide inhibitors of dengue virus and West Nile virus infectivity
... potential peptide inhibitors of WNV and DENV infectivity that target the viral E ...a peptide corresponding to the stem domain of DENV, inhibited infection by DENV (>99% inhibition of plaque ...
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Discovery of peptide inhibitors targeting human programmed death 1 (PD-1) receptor
... or peptide-like molecules to block the PD-1/PD-L1 interaction, which hopefully provides alternative drug candidates to overcome the drawbacks of antibody-based ...develop peptide inhibitors targeting ...
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1,3-Oxazol-4-ylphosphonium salts as new non-peptide inhibitors of furin
... non-peptide inhibitors of ...furin inhibitors showed that among the triphenylphosphonium salts studied by us, oxazole 12 containing 2,4-dichlorophenyl- in the c2-position and meS-group at c5 is the ...
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Development of proteolytically stable N methylated peptide inhibitors of aggregation of the amylin peptide implicated in type 2 diabetes
... the peptide inhibitors described in this report are designed to interact with amylin at the 11-20 ‘binding’ region (RLANFLVHSS), peptide derivatives from which show maximum binding to full-length ...
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Peptide Inhibitors of Flavivirus Entry Derived from the E Protein Stem
... stem peptide to the virion membrane, or ...DV3 peptide, which is the most distant of the three other peptides from DV2, is the most similar in its inhibitory strength and ...specific peptide binding ...
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Synthesis, biological evaluation and docking of novel bisamidinohydrazones as NON-peptide inhibitors of furin
... of peptide hormones, growth and differen tiation factors, adhesive molecules, recep- tors, ion channels, blood clotting factors, ...specific peptide bonds at the C-end of the segment, containing a cluster ...
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Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase
... fluoromethyl ketone proteinase inhibitors. For each inhibitor, effectiveness at inhibiting the activity of TCP correlated with effectiveness at both blocking hemoglobin degradation and killing cultured parasites. ...
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Genetic Pathway of HIV-1 Resistance to Novel Fusion Inhibitors Targeting the Gp41 Pocket
... short-peptide inhibitors either singly or in ...of inhibitors, whereas the E49K mutation on another NHR helix would introduce an electrostatic ...outcompeting inhibitors. Third, the resistance ...
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Structure based design, synthesis, and pharmacologic evaluation tf peptide RGS4 inhibitors
... I peptide has been prepared and was found to be devoid of inhibitory activity ...cyclic peptide analogs, as cyclization is expected to reduce conformational freedom and enhance binding affinity by mimicking ...
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Mechanism of HIV-1 Resistance to Short-Peptide Fusion Inhibitors Targeting the Gp41 Pocket
... tide inhibitors (10, 15–17, 21, 46) and in prolonged T20-contain- ing clinical therapy (11–14, 52, 55, ...diverse inhibitors (⬃3-fold), which empha- sized that the mechanism of N126K-mediated resistance is ...
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Selection of Peptide Inhibitor to Matrix Metalloproteinase-2 Using Phage Display and Its Effects on Pancreatic Cancer Cell lines PANC-1 and CFPAC-1
... MMP inhibitors have been tested in different clinical trials, especially MMP-2 ...MMP inhibitors in clinical trials. Until now, specific inhibitors of gelatinases have not been avail- able in ...
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A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum
... To obtain free amino acids for protein synthesis, trophozoite stage malaria parasites feed on the cytoplasm of host erythrocytes and degrade hemoglobin within an acid food vacuole. The food vacuole appears to be ...
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Specificity of the H-2 L(d)-restricted cytotoxic T-lymphocyte response to the mouse hepatitis virus nucleocapsid protein.
... single peptide of 11 candidates within the JHMV N protein extends numerous reports describing limita- tions of the predictive value of binding motifs (3, 4, 11, 18, ...Although peptide competition studies ...
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Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice
... sulfone inhibitors remain intact after target engagement [43], and are not toxic to mammals ...sulfone inhibitors do not cause cel- lular toxicity measured by mitochondrial activity, cell morphology, LDH ...
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Dental Erosion and Treatment Methods
... Dental erosion is the loss of substance that occurs in the hard tissues of the teeth without being related to a bacterial component as a result of acid attacks. This condition, which is caused by continuous acid ...
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MOLECULAR MODELING STUDY AND COMPUTER–AIDED DRUG DESIGN OF PEPTIDE DEFORMYLASE PDF INHIBITORS
... Looking at the superposition map of benzene–A1, we also found that benzene–A1 has longer scaffold as compared with ligand MLN2, which may result in exposing the tail group and it may weaken the binding affinity of the ...
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Identification of an HIV-1 Mutation in Spacer Peptide 1 That Stabilizes the Immature CA-SP1 Lattice
... Maturation inhibitors (MIs) prevent the final cleavage step at the site between the capsid protein (CA) and spacer peptide 1 (SP1), apparently by binding at this site and denying the protease ...
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Developing peptide based inhibitors of amylin aggregation as a novel treatment for type 2 diabetes
... developing peptide-based molecules as potential drug ...for peptide and protein analysis because chromatographs can be tailored to specific requirements via changes in mobile phase ...
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