Peptidyl-prolyl Isomerase
Investigating the Binding of Peptidyl-Prolyl Isomerase Pin1 to a Multi-Site Phosphorylated Substrate Modeled After Phosphatase CDC25C
... the peptidyl-prolyl isomerase Pin1 and how it binds to phosphorylated substrates and aims to determine whether a singly- phosphorylated substrate or a doubly-phosphorylated substrate has a lower ...
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Original Article Overexpression of peptidyl-prolyl isomerase 1 (Pin1) and cyclin D1 in endometrial cancer
... Abstract: The aim of this study is to investigate the expression and correlation of peptidyl-prolyl isomerase 1 (Pin1) and cyclin D1 in endometrial cancer. This retrospective study included 52 newly ...
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The peptidyl prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism
... the peptidyl-prolyl isomerase (PPIase) Pin1 has recently been shown to regulate the turnover of multiple cytokine mRNAs, we investigated the role of Pin1 in regulating PTH mRNA stability in rat ...
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Synthetic Lethality of Retinoblastoma Mutant Cells in the Drosophila Eye by Mutation of a Novel Peptidyl Prolyl Isomerase Gene
... Mutations that inactivate the retinoblastoma (Rb) pathway are common in human tumors. Such muta- tions promote tumor growth by deregulating the G1 cell cycle checkpoint. However, uncontrolled cell cycle progression can ...
12
Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD
... for peptidyl-prolyl bonds where the unique N-alkylation of proline markedly reduces the energy difference between the two conformations [1, ...of peptidyl-prolyl isomerases (PPIases) to ...
25
Peptidyl-Prolyl Isomerase Pin1 Is a Cellular Factor Required for Hepatitis C Virus Propagation
... siRNA-resistant isomerase-inactive mutant Pin1 (31), the substitution mu- tations S16A and C113A, respectively, were introduced into siRNA-resistant mutant ...
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Human Immunodeficiency Virus Type 1 Replication and Regulation of APOBEC3G by Peptidyl Prolyl Isomerase Pin1
... a peptidyl prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of X-Pro peptide bonds and promotes protein conformational changes (29, ...
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Characterizing the domain- and phosphorylation-requirements of the interaction between peptidyl prolyl isomerase Pin1 and mitotic phosphatase CDC25C
... dual-domain isomerase; having a WW domain and a PPIase catalytic domain which can both bind to the pSer/Thr-Pro motif (9, 12), raises the question of how Pin1 uses each domain when binding to, and subsequently ...
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Exploring the Structure and Biochemistry of Oxidation-Mediated Inhibitation of the Peptidyl-Prolyl Isomerase PIN1
... Cys113, isomerase assays were performed using a recombinant Pin1 enzyme containing a catalytically active C113D mutation (R14A C113D ...that isomerase activity of R14A C113D Pin1 will be unaffected by ...
93
Cyclophilins: The Structure and Functions of an Important Peptidyl-prolyl Isomerase
... of prolyl peptide bonds by PPIases [25] Folded proteins have peptide bonds in two conformations, cis and trans, and the torsional angles (dihedral angle) for the rotation about the C-N bond is tightly clustered ...
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Siepe, Dirk (2009): Role of the peptidyl-prolyl cis/trans isomerase Pin1 in the ubiquitin proteasome system (UPS). Dissertation, LMU München: Fakultät für Biologie
... This study describes a completely different mechanism of polyubiquitylation switching, which involves the highly conserved peptidyl-prolyl isomerase (PPIase) Pin1. Among the PPIases, Pin1 is special ...
92
Pin1 regulates parathyroid hormone mRNA stability
... Secondary hyperparathyroidism often occurs in chronic kidney disease (CKD) and vitamin D deficiency, resulting in increased fractures and mortality. Understanding factors that stimulate parathyroid hormone (PTH) ...
6
Hydrogen Exchange Mass Spectrometry for Studying Protein- Ligand Interactions
... Order Content Title Noncovalent binding of a cyclic peptide inhibitor to the peptidyl-prolyl isomerase Pin1, explored by hydrogen exchange mass spectrometry. Order Content Author Mo[r] ...
201
The Origin and Evolution of Release Factors: Implications for Translation Termination, Ribosome Rescue and Quality Control Pathways
... Comparably in bacteria, rescue solutions including the tmRNA/SmpB and ArfA systems emerged largely independently of a secondary peptidyl hydrolase activity [65,66] . These proteins harbor charged helical regions ...
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NmPin from the marine thaumarchaeote Nitrosopumilus maritimus is an active membrane associated prolyl isomerase
... phosphorylation as a regulatory mechanism is not generally excluded as numerous genomes of archaeal organisms contain open reading frames for potential protein kinases and protein phosphatases in homology to known ...
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The Ess1 Prolyl Isomerase Is Required for Growth and Morphogenetic Switching in Candida albicans
... Prolyl-isomerases (PPIases) are found in all organisms and are important for the folding and activity of many proteins. Of the 13 PPIases in Saccharomyces cerevisiae only Ess1, a parvulin-class PPIase, is ...
12
Original Article Over-expression of prolyl isomerase Pin1 promotes cervical tumorigenesis and metastasis
... the prolyl isomerase PIN1 is involved in tumorigenesis, but the role of PIN1 in cervical cancer is ...the prolyl isomerase PIN1 in cervical cancer indicates tumor-Promotive properties of PIN1 ...
11
Hmo1p, a High Mobility Group 1/2 Homolog, Genetically and Physically Interacts With the Yeast FKBP12 Prolyl Isomerase
... The immunosuppressive drugs FK506 and rapamycin bind to the cellular protein FKBP12, and the resulting FKBP12-drug complexes inhibit signal transduction. FKBP12 is a ubiquitous, highly conserved, abundant enzyme that ...
10
Peptidylproline cis-trans-Isomerase Pin1 Interacts with Human T-Cell Leukemia Virus Type 1 Tax and Modulates Its Activation of NF-κB
... Pin1 contributes to Tax signaling through NF- B. The func- tional impact of phosphorylation-dependent prolyl isomeriza- tion is complex and not fully understood (66). The above re- FIG. 2. Tax binds Pin1. (A) In ...
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The ESS1 Prolyl Isomerase and Its Suppressor BYE1 Interact With RNA Pol II to Inhibit Transcription Elongation in Saccharomyces cerevisiae
... Transcription by RNA polymerase II (pol II) requires the ordered binding of distinct protein complexes to catalyze initiation, elongation, termination, and coupled mRNA processing events. One or more proteins from each ...
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