Phagosome maturation
Candida albicans Hypha Formation and Mannan Masking of β Glucan Inhibit Macrophage Phagosome Maturation
... [early phagosome maturation]), and panel D shows Magic Red cathepsin (activated cathepsin B), indicating phagosome-lysosome fusion (late phagosome ...
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Relief from Zmp1-Mediated Arrest of Phagosome Maturation Is Associated with Facilitated Presentation and Enhanced Immunogenicity of Mycobacterial Antigens
... It is widely assumed that tuberculosis disease will protect, at least partially, against subsequent reinfection (1). However, the failure of natural disease to protect against reinfection (36) indicates that immunity ...
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Saxifragifolin D attenuates phagosome maturation arrest in Mycobacterium tuberculosis-infected macrophages via an AMPK and VPS34-dependent pathway
... the phagosome, which then matures into a phagolysosome through a series of fusion reactions with lysosomes (Flannagan et ...the maturation of the phagosome is crucial for alveolar macrophages to kill ...
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Helicobacter pylori phagosome maturation in primary human macrophages
... In the first stage of the phagosome maturation pro- cess, phagosomes normally recruit markers characteris- tic of early endosomes. Here we report that the early endosome marker EEA1 was recruited to H. ...
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The Capsule of Cryptococcus neoformans Modulates Phagosomal pH through Its Acid-Base Properties
... the phagosome with the potential to mediate considerable buffering ...the phagosome by its buffering capacity during conditions of both phagosomal acidification and phagosomal membrane leak- ...
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Characterizing Ferroportin Trafficking in Macrophages During Phagocytosis
... Macrophages are important mediators of innate immunity and nutritional immunity via modulation of essential nutrients like iron during bacterial infection. Ferroportin (Fpn), an iron-exporting protein, is found on the ...
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Long-term smoking alters abundance of over half of the proteome in bronchoalveolar lavage cell in smokers with normal spirometry, with effects on molecular pathways associated with COPD
... killed and subsequently degraded into fragments. The levels of three phagocytotic proteins were altered in Smokers compared to Never-smokers: Syntaxin 12 and transferrin receptor 1, co-localize in the recycling endo- ...
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Phagosome lysosome Fusion Hijack An Art of Intracellular Pathogens
... phagosomes. Phagosome itself neither can destroy the pathogens nor inhibits the replication of pathogens, because the lumen of nascent vacuole is similar to the fluid phase outside macrophages, except that it is ...
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Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette Guérin mutants that secrete listeriolysin
... maturing phagosome. However, BCG arrests phagosome maturation at an early stage and prohibits pH ...of maturation arrest could be overcome, at least partially, by the removal of ...
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Characterization of Efferosome Maturation and the Processing of Apoptotic Bodies
... efferocytic maturation process is not as well understood as the phagocytic process, some of the mechanisms have been studied in the ...efferosome maturation in ...Common phagosome maturation ...
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Th1 Th2 polarisation and autophagy in the control of intracellular mycobacteria by macrophages
... in phagosome biogenesis (MacMicking et ...inhibit maturation of the macrophage phagosome, preventing fusion with lysosomes, while still allowing fusion with transferrin-containing endosomes, thus ...
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Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants
... bodies. Phagosome formation and subsequent maturation require extensive cytoskeletal rear- rangement and precisely choreographed vesicular fusion and fission ...disrupt phagosome maturation ...
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Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis
... the maturation of mycobacteria-containing phagosomes in human mac- ...IFN-␥–induced phagosome maturation in phorbolmyristate acetate– differentiated human THP-1 ...some maturation in primary ...
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Influence of sexual maturation status on the relationship between body adiposity indicators and age: a cross sectional study
... sexual maturation to adiposity indicators were conducted in Norway and the United ...sexual maturation status was asso- ciated with ...sexual maturation can influence both subcutaneous adipose and ...
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Original Article Upregulation of cell surface estrogen receptor alpha is associated with the mitogen-activated protein kinase/extracellular signal-regulated kinase activity and promotes autophagy maturation
... tively at the maturation step, not the initial step, disrupting the maturation of autophagosomes into functional autolysosomes (i.e., significant increasing in autophagy formation and delaying in autophagy ...
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Chloroplast incorporation and long-term photosynthetic performance through the life cycle in laboratory cultures of Elysia timida (Sacoglossa, Heterobranchia)
... clutch maturation, which was lower in Banyuls- sur-mer (16–22°C) than in the laboratory (20–23°C), again corresponding to the 20–24°C from Marín and Ros ...
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Protease mediated maturation of HIV: Inhibitors of protease and the maturation process
... particle through Gag-Gag interactions. Gag-Pol is expressed via a − 1 ribosomal frameshift during approximately 5– 10% of Gag translation events. The Pol domain encodes the viral PR, RT, and IN proteins. Gag-Gag ...
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Metastable Intermediates as Stepping Stones on the Maturation Pathways of Viral Capsids
... Intermediates in other viral systems. How widespread are meta- stable transition states of maturing capsids? Assessment is con- strained by the fact that pertinent data are available for only a few viruses. However, it ...
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The maturation of the field
... So I imagine it would be with this model. Our child like strategies are of as much worth as our youth and adult approaches in the right context. They will blend into a seamless response to individual or collective ...
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Optimization of Regeneration and Agrobacterium-Mediated Transformation Protocols for Selected Kenyan Cassava (Manihot Esculenta Crantz) Genotypes
... somatic embryo maturation and plant recovery of the selected cassava genotypes Embryos in the cotyledonary stage were incubated in maturation medium supplemented.. with five[r] ...
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