phase 3 clinical trial (topic)
First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma
... study. (1) Patients are screened prior to surgery, so glioblastoma (GBM) determination is made from pathological diagnosis after surgery. (2) Insufficient tumor lysate generated to meet threshold. (3) Progressive ...
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Update on the Preventive Antibiotics in Stroke Study (PASS): a randomised controlled phase 3 clinical trial
... Infection rate during hospital admission will be assessed in two ways. First, clinical diagnosis according to the treating physician will be recorded. Second, diagnosis of infection will be judged by two ...
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Discrete strategies to reduce intake of discretionary food choices: a scoping review
... OR Clinical Trials OR Phase 1 clinical trial OR Phase 2 clinical trial OR Phase 3 clinical trial OR Phase 4 clinical trial ...
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<p>Efficacy and Safety of Anlotinib in Advanced Non-Small Cell Lung Cancer: A Real-World Study</p>
... a Phase III clinical trial (ALTER0303), anlotinib prolonged the median progression-free survival (PFS) by 4 months and the median overall survival (mOS) by ...randomized clinical trials, and ...
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Efficacy and Safety of Tedizolid Phosphate versus Linezolid in a Randomized Phase 3 Trial in Patients with Acute Bacterial Skin and Skin Structure Infection
... early clinical response rate ...early clinical response rates at 48 to 72 h were demonstrated between tedizolid and linezolid treatment arms in the modified ITT ...programmatic clinical response at ...
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<p>Prospect of immunotherapy combined with anti-angiogenic agents in patients with advanced non-small cell lung cancer</p>
... 24–27 Phase III clinical trials (ECOG 4599) evaluated the ef fi cacy of beva- cizumab (Bev) in combination with carboplatin (C) and paclitaxel (P) as fi rst-line treatment in patients with meta- static or ...
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Next generation of immune checkpoint therapy in cancer: new developments and challenges
... under phase I clinical test in combination with durvalumab and radiation ther- apy in metastatic or locally advanced solid malignancies ...a phase I clinical trial in patients with ...
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A quantitative analysis of therapeutic cancer vaccines in phase 2 or phase 3 trial
... or clinical endpoints [8, 13, ...‘randomized’ trial setting (NCT00324831, NCT00524277, NCT00769704) though at least 30 trials (non-randomised, randomized or treatment design) include GM-CSF alone as a form ...
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Addressing the challenges to successful recruitment and retention in Alzheimer's disease clinical trials
... a phase III trial of tarenfl urbil included mild-to-moderate AD patients with an MMSE score of between 15 and ...a phase II study [9]. Overall trial recruitment occurred from Feb- ruary 2005 ...
11
Thesis
... The multi-site, Phase 3 trial of RTS,S/AS01, the most advanced candidate malaria vaccine, is complete. Across 11 study sites in seven countries in sub-Saharan Africa, administration of the vaccine in ...
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Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report
... the clinical trials will be randomized and double blinded if possible, with due consideration of the technical and logistic constraints at the trial ...malaria clinical trials results with recom- ...
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Integrated safety in tocilizumab clinical trials
... Pivotal Trial in methotrexate Inadequate respONders (OPTION) [1], Actemra (Roche; Nutley, NJ, USA) versus Methotrexate double-Blind Investigative Trial In mONotherapy (AMBITION) [5] (including the ...
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Qualitative and quantitative validation of the FACIT-fatigue scale in iron deficiency anemia
... three clinical sites in the United ...a clinical diagnosis of IDA [measurable hemoglobin (Hgb) range of > 7 g/dL to < 10 g /dL and transferrin saturation (TSAT) < 20 %]; they were able to speak and ...
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<p>Evaluating the Safety and Efficacy of Nivolumab in Patients with Advanced Hepatocellular Carcinoma: Evidence to Date</p>
... a Phase Ib/II clinical trial involving advanced HCC patients whose disease pro- gressed on sorafenib or who did not tolerate sorafenib (Checkmate-040 ...The trial included Child-Pugh class A ...
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A new trial design to accelerate tuberculosis drug development : the Phase IIC Selection Trial with Extended Post treatment follow up (STEP)
... in clinical develop- ...earlier clinical trial data on efficacy into the decision-making ...Fig. 3), if considering data from a murine study as having half the strength of a human study (a = ...
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Inotuzumab ozogamicin: a CD22 mAb–drug conjugate for adult relapsed or refractory B-cell precursor acute lymphoblastic leukemia
... in Phase 1/2 and Phase 3 clinical trials and it demonstrated improved complete remission rates, progression-free survival and overall survival in relapsed or refractory adult ALL compared to ...
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Knowledge, Attitudes, and Experiences of HIV Pre Exposure Prophylaxis (PrEP) Trial Participants in Botswana
... vention clinical trials [6] [10] [11] [13] ...with trial participants who were retained in the ...TDF2 trial than those who were not retained or did not agree to participate in an ...a Phase ...
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The need for comparative data in spondyloarthritis
... placebo-controlled phase of clinical trials, which is important for chronic diseases requiring long-term treatment, like ...one trial being compared with published whole- population data from ...
6
Combination therapy with histone deacetylase inhibitors (HDACi) for the treatment of cancer: Achieving the full therapeutic potential of HDACi
... Numerous phase I clinical trials have been conducted with the combination of sorafenib and HDACi for treating patients with advanced/metastatic solid malignancies and refractory/relapsed acute myeloid ...
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Emerging therapeutic potential of nanoparticles in pancreatic cancer: a systematic review of clinical trials
... first clinical trial using Rexin-G in the treatment of pancreatic cancer in the Philippines was performed by Gordon et ...to 3 × 10 11 colony forming units; tumour growth was arrested in three of ...
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