phase II enzymes
An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects
... both phase I and phase II detoxification enzymes because both phase I and phase II detoxification enzymes are important for regu- lating the concentration of toxic ...
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Antioxidant Defense: Effects of an NRF2 ARE Polymorphism on the Activation of Phase II Enzymes
... Expression studies of downstream antioxidant induction have focused on complete ablation of nrf2. Our functional studies have shown that alterations in the NRF2 ARE affect functional activity which may affect downstream ...
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Nrf2 target genes are induced under marginal selenium-deficiency
... hand, phase II enzymes like the GST, SULT and UGT family are involved in the conju- gation and excretion of xenobiotic ...antioxidant enzymes like peroxiredoxins, sulfiredoxin, Sod1, Hmox1 and ...
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In vivo induction of phase II detoxifying enzymes, glutathione transferase and quinone reductase by citrus triterpenoids
... of phase II detoxification ...of phase II enzymes enhances the ability of an organism to effectively detoxify ...of phase II enzymes may be a potential ...
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DMET TM (Drug Metabolism Enzymes and Transporters): a pharmacogenomic platform for precision medicine
... Otherwise, phase II drug metabolizing enzymes typically enable the biotransformation of endogenous compounds and xenobiotics and their excretion by considerably increasing the hydrophilicity of the ...
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In vitro effect of mitragynine on activity of drug metabolizing enzymes, n-demethylase and glutathione s-transferase in streptozotocin-induced diabetic rats
... called phase I and phase II reactions. In phase I reaction nonpolar molecules undergo hydrolysis, reduction or oxida- tion and converted into polar ...[16]. Phase II reactions ...
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Phytochemicals in Vegetables and Health Protective Effects
... of Phase I enzymes serve as substrates for Phase II enzymes, which convert them into electrophilic carcinogens that can easily be excreted through the ...PhaseI enzymes ...
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Original Article Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary fibrosis in rat by activating Nrf2 signaling
... The optimal therapy for pulmonary fibrosis remains controversial. No agent has been rigor- ously shown to improve the survival or quality of life for patients with pulmonary fibrosis [31]. Lung transplantation is ...
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Chemopreventive activity of sulforaphane
... of Phase I DMEs is the induction of Phase II DMEs, which transform carcinogens to inactive metabolites that are easily eliminated from the body, thus preventing their reaction with ...of Phase ...
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Effect of an ethanol extract of Descurainia sophia seeds on Phase I and II drug metabolizing enzymes and P glycoprotein activity in vitro
... by Phase II enzymes and also in- volved in the metabolism of several important endogenous substances such as bilirubin, steroid hormones, thyroid hormones, bile acid, and fat-soluble vitamins [34], ...
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Randomized phase II designs.
... randomized phase II design can achieve its statistical objectives while maintaining a relatively small sample size, which is the case of directly comparing two experimental regimens, primarily for the ...
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Cellulases without carbohydrate-binding modules in high consistency ethanol production process
... with an average molecular weight of 6,000 g/mol (PEG 6000, 10 g/kg DM) was added before addition of en- zyme. The cellulases TaCel7A and TaCel5A (with or without CBM), as well as XYL (TaXyn10A) and BG (TaCel3A) were ...
11
Osimertinib in the treatment of non-small-cell lung cancer: design, development and place in therapy
... Until recently, there were no standard therapeutic options in the setting of acquired resistance to initial EGFR TKIs and, outside clinical trials with investigational drugs, EGFR- mutated NSCLC patients generally ...
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The Crystal Structure of D212 from Sulfolobus Spindle-Shaped Virus Ragged Hills Reveals a New Member of the PD-(D/E)XK Nuclease Superfamily
... cleavage enzymes suggests that it may function as a junctional ...archaeal enzymes posi- tion their two active site centers on a relatively flat surface (8, 34, 37) and are predicted to recognize a planar, ...
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Impact of etanercept tapering on work productivity in patients with early rheumatoid arthritis: results from the PRIZE study
... during phase I. During phase III, among all patients who remained in the study, regardless of which treatment group they were in, paid work prod- uctivity loss was maintained the same as their loss at the ...
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Intradermal injection of a Tat Oyi based therapeutic HIV vaccine reduces of 1 5 log copies/mL the HIV RNA rebound median and no HIV DNA rebound following cART interruption in a phase I/II randomized controlled clinical trial
... The primary outcome for phase II was the capacity to control HIV RNA rebound in a vaccine group following treatment interruption.. The secondary outcome for phase I and phase II was a sp[r] ...
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The crystal structures of the low-temperature and high-pressure polymorphs of nitric acid
... The phase-II hydrogen bond contact distances obtained from the neutron diffraction study are slightly longer than those determined by single-crystal X-ray diffraction methods, despite the pressures for both ...
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Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes
... lamellar phase is not compatible with the diffusion of water-soluble sub- strate and product of the type needed to support activity that can be monitored by coupled enzyme ...
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Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes
... cubic phase; their water-soluble counterparts, glycerol 3-phosphate and cyti- dine monophosphate, respectively, move freely in and out of the PgsA laden bolus facilitating direct spectrophotometric ...cubic ...
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1963 05 #23 pdf
... In phase II, after the first clock pulse, an associative cell is in the 0 state if in phase I it contained the same information as the compare flip-flop.. After the phase II output has b[r] ...
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