physiologically-based pharmacokinetic modeling/PBPK
<p>Ethosome-Derived Invasomes as a Potential Transdermal Delivery System for Vardenafil Hydrochloride: Development, Optimization and Application of Physiologically Based Pharmacokinetic Modeling in Adults and Geriatrics</p>
... The PBPK model-simulated pharmacokinetic parameters of VRD following oral administration of an aqueous drug dispersion in geriatrics revealed a higher mean C max value ...
15
In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats
... the liver is systematically underestimated at the end of this study. Our model could not predict an increase over time large enough to reach the measured levels 7-day post exposure (Additional file 5). Certain ...
20
Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans
... developed PBPK model reasonably predicted the pharmacokinetics of the CYP2D6-sensitive substrates, metoprolol, desipramine, dextromethorphan, imipramine, and tolterodine independent of the CYP2D6 phenotype in the ...
14
Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose- and route-dependent biokinetics
... of PBPK mod- eling to better understand the biokinetics of ...First, PBPK modeling can be used to challenge or generate ...the PBPK model described herein supports the hypothesis that coating ...
16
Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach
... CNS PBPK model could successfully predict their concentration-time pro fi les in multiple human CNS compartments in physiological CNS conditions within a ...
13
<p>The Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling</p>
... enzymes but speci fi cally CYPs 1A2, 2D6 2C19, and 3A4; enzyme expression is reduced as disease severity increases. 43 Liver failure can alter a few elements of medication PK, including absorption, distribution and ...
11
Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination
... of PBPK modeling is deeply rooted in the independence of the model building on the output data representing the process to be ...is based on the integration within a whole entity of drug specific ...
13
Fixed-dose combination orally disintegrating tablets to treat cardiovascular disease: formulation, in vitro characterization and physiologically based pharmacokinetic modeling to assess bioavailability
... The potential to enhance therapy for patients suffering both dyslipidemia and hypertension with an orally disinte- grating FDC for amlodipine and atorvastatin is substantial. Since no change in bioavailability for ...
16
Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content
... using PBPK modeling to interpret the effects of multiple nanoparticle properties on their ...a PBPK modeling approach for the building of nanoparticle property-distribution relation- ships in ...
12
Physiologically based pharmacokinetic modeling of zinc oxide nanoparticles and zinc nitrate in mice
... NP-based PBPK model. A nanometal PBPK model with adequate predictive power can be used to investigate mechani- cal processes, evaluate hypotheses, and guide experimental designs and also has ...
16
Compartmentalizing the Sunlight Vitamin: Physiologically Based Pharmacokinetic Modeling and Vitamin D.
... A pharmacokinetic model is a quantitative, rather than qualitative description of chemical behavior in biological systems over a period of ...tissues. Physiologically- based pharmacokinetic ...
140
Toward a general physiologically-based pharmacokinetic model for intravenously injected nanoparticles
... by physiologically-based pharmacokinetic (PBPK) ...nano PBPK models developed to date all concern a single type of ...general PBPK model for nondegradable NPs injected ...
16
Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112
... etc. PBPK modeling was performed to evaluate the drug disposition in rats following administration of the nanocrys- tals using drug cosolvent as a ...rat PBPK model incorporating the parameters of ...
15
Physiologically based pharmacokinetic (PBPK) modeling of benzene in humans: a Bayesian approach
... statistical modeling and ...physiological modeling were brought together to model the distribution and metabolism of benzene in ...combining PBPK models and MCMC methodology for Bayesian inference ...
33
A Comparison of Physiologically-Based Pharmacokinetic (PBPK) Models of Methyl-Tertiary Butyl Ether (MTBE).
... mathematical modeling perspective, the analysis of a descriptive or predictive model that fits the data collected from a study may provide some information that could possibly drive the design of future kinetic ...
135
PKQuest Java: free, interactive physiologically based pharmacokinetic software package and tutorial
... body" PBPK organ model (Figure 1) with each organ characterized by an adjustable volume, blood flow, capillary permeability, metabolism and tissue/blood partition ...the PBPK approach is uncertainty ...
6
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR PLANT BASED ANTI OXIDANT DRUGS
... of physiologically-based pharmacokinetic (PBPK) study is necessary for the validation of ...drug. PBPK is cumbersome and tedious in the regular lead identification ...drug-based ...
7
Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models
... WB-PBPK modeling allows for the simulation of the fate of xenobiotics in the human body on the basis of individ- ual physiological characteristics ...
15
Physiologically Based Pharmacokinetic Models for the Systemic Transport of Trichloroethylene
... standard PBPK models, which make use of “perfusion-limited” and “dif- fusion-limited” compartments, are designed around the assumption of rapid equilib- rium and uniformity within each compartment or ...
248
Applications of Physiologically Based Pharmacokinetic Models in Veterinary Medicine.
... probabilistic modeling technique that uses distributions rather than single points to define ...into PBPK modeling and have been applied to human health risk assessment (Cox, 1996; Jonsson et ...
166