PI3K/Akt/eNOS
Original Article Silent information regulator 1 ( SIRT1 ) promotes the migration and proliferation of endothelial progenitor cells through the PI3K/Akt/eNOS signaling pathway
... The PI3K/Akt pathway provides essential sig- naling for cell survival and ...different eNOS agonists, such as VEGF, insulin, estrogen, and platelet-derived lipid mediators, can affect eNOS ...
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MicroRNA-130a alleviates human coronary artery endothelial cell injury and inflammatory responses by targeting PTEN via activating PI3K/Akt/eNOS signaling pathway
... [27]. PI3K, known as a heterodimeric enzyme, plays an important role in proliferation and apoptosis, while Akt, a downstream serine-threonine kinase, transmits survival signals from growth ...that ...
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Wen Xin Decoction ameliorates vascular endothelium dysfunction via the PI3K/AKT/eNOS pathway in experimental atherosclerosis in rats
... The other commercial products used in this study were as follows: atorvastatin calcium (Pfizer, Lipitor; code number approved by SFDA: J20070061), vitamin D3 (Shanghai General Pharmaceutical Co., Ltd.; code number ...
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<p>Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K/Akt/eNOS Pathway</p>
... of PI3K/Akt/eNOS signaling orchestrates protective actions against endothe- lial dysfunction and ...by Akt, thus inhibiting cell apoptosis and facilitating cell proliferative ability by miti- ...
13
<p>(-)-Epigallocatechin-3-Gallate Inhibits eNOS Uncoupling and Alleviates High Glucose-Induced Dysfunction and Apoptosis of Human Umbilical Vein Endothelial Cells by PI3K/AKT/eNOS Pathway</p>
... the PI3K/AKT/eNOS signaling ...of eNOS activity and up-regulation of the PI3K/AKT path- ...increasing eNOS expression and acti- vating the PI3K/AKT ...
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Original Article PI3K/AKT signaling pathway plays a role in enhancement of eNOS activity by recombinant human angiotensin converting enzyme 2 in human umbilical vein endothelial cells
... phosphorylation eNOS level was also observed in the pres- ence of LY294002 (10 μmol/L) (PI3K/AKT ...of eNOS and phosphorylated ...phosphorylated eNOS were significantly higher than in ...
6
Original Article Vaspin alleviates dysfunction of endothelial progenitor cells induced by high glucose via PI3K/Akt/eNOS pathway
... decreased eNOS, FoxO1, and Akt phosphorylation, which inhibit the bioavailability of NO leading to reduce the number and migration capacity of ...by eNOS inhibitor L ...
8
Reverse-D-4F improves endothelial progenitor cell function and attenuates LPS-induced acute lung injury
... circulating EPC, promotes endothelial regeneration, and attenuates neointima formation in a murine model of transplant arteriosclerosis [27]. ApoA-I mimetic peptide D-4F, mimicking ApoA-I class A amphipathic helices, ...
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Anaphylactic shock depends on PI3K and eNOS derived NO
... constitutive eNOS, rapidly activated via the PI3K ...NOS, PI3K, or Akt or eNOS deficiency provided complete ...that eNOS-derived NO is the principal vasodilator in anaphylactic ...
9
Arsenite Activation of PI3K/AKT Cell Survival Pathway is Mediated by p38 in Cultured Human Keratinocytes
... of AKT by PI3K results in the inhibition of proapoptotic signals and the promo- tion of survival signals ...activated AKT in cultured human ker- atinocytes in a time dependent ...of eNOS, ...
6
<p>SPOCD1 accelerates ovarian cancer progression and inhibits cell apoptosis via the PI3K/AKT pathway</p>
... Results: SPOCD1 expression was signi fi cantly upregulated in OC tissues compared with non-cancerous tissues (P<0.01), and was positively correlated to FIGO stage and tumor grade of OC. Also, SPOCD1 was signi fi cantly ...
9
<p>Network Pharmacology-Based Prediction and Verification of the Active Ingredients and Potential Targets of Zuojinwan for Treating Colorectal Cancer</p>
... (Abclonal), PI3K (cell signal technique), AKT (cell signal technique), p-AKT (cell signal technique), BCL2 (Abclonal), and BAX (cell signal technique) at 4°C ...
16
treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway
... addition, PI3K/Akt pathway activity promotes ubiquitination and degradation of p53 ...when PI3K/Akt signaling was inhibited, indicating that H 2 O 2 or serum starvation ...
12
Original Article DNA methylation profiles in the hippocampus of an Alzheimer’s disease mouse model at mid-stage neurodegeneration
... Received April 17, 2018; Accepted October 26, 2018; Epub November 15, 2018; Published November 30, 2018 Abstract: Aberrant DNA methylation is involved in many neurodegenerative diseases, such as Alzheimer’s disease (AD), ...
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Loss of Akt activity increases circulating soluble endoglin release in preeclampsia:identification of inter-dependency between Akt-1 and heme oxygenase-1
... the PI3K/Akt pathway in human lung epithelial ...that PI3K/Akt activation is decreased in the organs of HO-1 null mice and that increased PI3K/Akt activation induces HO-1 ...
9
Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma
... However, long-term ASPP2 overexpression (more than 48 hours) fails to induce apoptosis in HepG2 and PHCs, suggesting that hepatoma cells can also prevent long-term apoptotic stimuli. We believe that the plausible ...
10
Original Article UBE2T silencing inhibits TGF-β1-induced epithelial-to-mesenchymal transition in colon cancer cells
... Cells were lysed in lysis buffer containing 1% NP40, 1 mM EDTA, 50 mM Tris-HCl (pH 7.5) and 150 mM NaCl, supplemented with complete protease inhibitors mixture (Roche, Monza, Italy). Protein concentrations were measured ...
7
Original Article The role of the PI3K/Akt/GSK-3β pathway in postoperative cognitive dysfunction in elderly rats
... The PI3K/Akt pathway is a classical anti- apoptosis and pro-survival pathway that exerts an important role in ischemic brain protecti- on, neovascularization, and anti-apoptosis ...The ...
7
Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress- mediated survival of melanoma cells
... of AKT/mTOR pathway have been dogged by complications due to activation of AKT by feedback from the TORC2 complex, which phosphorylates AKT at serine 473 to activate ...
14
<p>MicroRNA-145 inhibits growth of laryngeal squamous cell carcinoma by targeting the PI3K/Akt signaling pathway</p>
... Tumor development is a complex process involving multiple factors and stages, typically arising from the accumulation of multiple gene mutations. As a result, the etiology and biological mechanisms underlying the prolif- ...
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