PI3K signaling
Epidermal Growth Factor Receptor PI3K Signaling Controls Cofilin Activity To Facilitate Herpes Simplex Virus 1 Entry into Neuronal Cells
... ABSTRACT Herpes simplex virus type 1 (HSV-1) establishes latency in neurons and can cause severe disseminated infection with neurological impairment and high mortality. This neurodegeneration is thought to be tightly ...
15
Arg972 Insulin receptor substrate-1 is associated with decreased serum angiotensin-converting enzyme 2 levels in acute myocardial infarction patients: in vivo and in vitro evidence
... insulin/IRS-1/PI3K signaling is required for ACE2 expression in cardiomyocytes, and that hypoxia can markedly enhance the induction effect of insulin/IRS-1/PI3K signaling on ACE2 expression in ...
10
Hyperactivation of phosphatidylinositol 3 kinase promotes escape from hormone dependence in estrogen receptor–positive human breast cancer
... the PI3K substrate AKT. Inhibition of PI3K and mTOR induced LTED cell apoptosis and prevented the emergence of hormone-independent ...of PI3K pathway activation that predicted poor outcome after ...
9
Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers
... We examined the impact of EZN4150 on growth of SKBR3, BT474 and UACC893 HER2+ cells. EZN4150 treatment for 12 days decreased SKBR3 cell numbers >10-fold as compared to EZN3046 treatment (Fig. 1a), while decreasing ...
11
A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma
... potential PI3K inhibitors of which C96 has been demonstrated to induce MM cell death by targeting the PI3K signaling ...inhibit PI3K activity, a MM cell line OPM2 which displays high ...
11
<p>MicroRNA-145 inhibits growth of laryngeal squamous cell carcinoma by targeting the PI3K/Akt signaling pathway</p>
... The PI3K signaling pathway is an important cellular signal transduction ...of PI3K, serving as an intermediate regulatory link in the PI3K/Akt signal transduction pathway to control the ...
12
The dual PI3K/mTOR inhibitor BEZ235 restricts the growth of lung cancer tumors regardless of EGFR status, as a potent accompanist in combined therapeutic regimens
... Over the last 10 years, there have been concerted re- search efforts to develop molecular histological tech- niques and targeted therapies for cancer. Small-molecule epidermal growth factor receptor tyrosine kinase ...
16
RALB provides critical survival signals downstream of Ras in acute myeloid leukemia
... and PI3K effector pathways. Activation of MAPK signaling is initiated by Ras-GTP binding of RAF kinases that results in localization to the plasma membrane and activation of their serine/threonine kinase ...
10
Vol 68, No 3 (2016)
... PI3K/Akt signaling pathways exist in a large number of mammalian cells and exert multiple pro- survival functions, including cell proliferation, dif- ferentiation, survival, migration, invasion and me- ...
9
Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes
... interrogating signaling pathways for their impact on oncogenic properties, with a specific focus on drug ...17 signaling pathways that had been previously found to be frequent players in oncogenic processes ...
11
Original Article The characterization and clinical significance of PI3K/ Akt signaling pathway activation in the peripheral T cells of pediatric patients with atopic dermatitis
... downstream signaling protein of PI3K. Recent studies have shown that the PI3K signaling pathway is involved in T cell migration and that it plays an important regula- tory role in CD3- and/or ...
7
<p>Guava Leaf Extract Attenuates Insulin Resistance via the PI3K/Akt Signaling Pathway in a Type 2 Diabetic Mouse Model</p>
... IRS-1, PI3K and Akt mRNAs were detected using real-time PCR ...IRS-1, PI3K and Akt were calculated using the 2 −ΔΔ CT method, and β -actin was used as a housekeeping ...
6
Original Article Silent information regulator 1 ( SIRT1 ) promotes the migration and proliferation of endothelial progenitor cells through the PI3K/Akt/eNOS signaling pathway
... The PI3K/Akt pathway provides essential sig- naling for cell survival and ...the PI3K/AKT ...signal PI3K/Akt pathway and the endothelial specific eNOS/NO pathway were closely associated with vascular ...
14
Autocrine PDGFR signaling promotes mammary cancer metastasis
... EMT-specific upregulation of PDGFR pathway genes generates an autocrine PDGF/PDGFR loop. (A) Regulation of PDGFR pathway genes in various cell pairs based on EpH4 mouse mammary epithe- lial cells that undergo ...
11
A pro inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor associated periodic syndrome (TRAPS)
... Jak/STAT signaling may be a consequence of the combined effects of enhanced ligand-independent signaling by mutant TNFR1 and an autocrine feedback loop resulting from IL-6 ...ligand-independent ...
15
treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway
... inhibit PI3K and autophagy, respectively, and the examined the expression of genes involved in the PI3K/Akt signaling pathway and ...the PI3K/Akt signaling pathway increased autophagy ...
12
How to Make a Mudsparkler
... Other Signaling pathways contributing mechanical stimuli induced muscle hypertrophy Satellite cell activation and Myogenesis: Skeletal muscle satellite cells are quiescent cells located adjacent to muscle fibers ...
328
Effect of PI3K/Akt Signaling Pathway on PRAS40Thr246 Phosphorylation in Gastric Cancer Cells
... of PI3K, AKT, p-PI3K, p- AKT, and p-PRAS40-Thr246 in gastric cancer cells and normal gastric mucosal epithelial cells were detected, and it was found that those levels in the gastric cancer cells were ...
9
Roxarsone induces angiogenesis via PI3K/Akt signaling
... the PI3K/Akt axis in various types of tumor cells. PI3K/Akt signaling is implicated in different processes that are characteristic of cancer including growth signal auton- omy, insensitivity to ...
13
Original Article shRNA-mediated silencing of PKHD1 gene promotes proliferation, migration and invasion of human intrahepatic cholangiocarcinoma HuCCT-1 cells
... Abstract: Intrahepatic cholangiocarcinoma (ICC), a type of cholangiocarcinoma, is characterized by insidious onset and lack of typical clinical symptoms at early onset, and the lack of effective treatments results in a ...
14