piwi-interacting RNA
Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas
... termed Piwi-interacting RNAs (piRNAs) has essential functions in stem cell division, apoptosis, and epigenetic control of transposons and telo- mers, but also in translational regulation ...
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Piwi-Interacting RNAs (piRNAs) Are Dysregulated in Renal Cell Carcinoma and Associated with Tumor Metastasis and Cancer-Specific Survival
... Piwi-interacting RNAs (piRNAs) are a distinct group of small noncoding RNAs (sncRNAs) that silence transposable genetic elements to protect genome integrity. Because of their limited expression in gonads ...
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Endogenous Viral Elements Are Widespread in Arthropod Genomes and Commonly Give Rise to PIWI-Interacting RNAs
... of PIWI-interacting RNAs (piRNAs) in some mosquito species and cell lines, raising the possibility that EVEs may serve as a source of immunological memory in these ...small RNA se- quencing data sets ...
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The disease-related biological functions of PIWI-interacting RNAs (piRNAs) and underlying molecular mechanisms
... non-coding RNA genomic regions, which suggest that the corresponding transcript might serve as piRNA precursors that subsequently leading to the regulation of their host ...as PIWI genes were evaluated for ...
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<p>Piwi-Interacting RNA1037 Enhances Chemoresistance and Motility in Human Oral Squamous Cell Carcinoma Cells</p>
... Total RNA was extracted from the beads using miRcute miRNA isolation ...biotin-labeled RNA oligonucleotides were synthesized by BioSynthesis, ...labeled RNA was incubated with protein extracts ...
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<p>The emerging roles of PIWI-interacting RNA in human cancers</p>
... and PIWI, the biogenesis and functions of piRNAs need further elucidation to improve our under- standing of their role in the development of diverse diseases, especially in ...
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PIWI-interacting RNA-54265 is oncogenic and a potential therapeutic target in colorectal adenocarcinoma
... Total RNA from cell lines and clinical tissues was extracted with Trizol reagent (Invitrogen), while total RNA from human serum samples was extracted with the MagMAX™ mirVana™ Total RNA Isolation Kit ...
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Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins
... The piwi genes (P-element-induced wimpy testis) were first identified as important players in the asymmetric division of germline stem cells in Drosophila [9] .... PIWI proteins play essential roles in the ...
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<p>The Importance of Small Non-Coding RNAs in Human Reproduction: A Review Article</p>
... Background: MicroRNAs (miRNA) play a key role in the regulation of gene expression through the translational suppression and control of post-transcriptional modi fi cations. Aim: Previous studies demonstrated that miRNAs ...
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TE studies in Japan: The third Japanese meeting on host-transposon interactions
... small RNA-mediated regulation, small RNAs are also involved in transcriptional gene silencing (TGS) in many ...by Piwi-interacting RNAs (piRNAs) in the Drosophila ovarian somatic cell line (OSC), ...
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Inhibitory Effects of Securinine and Related Compounds on Toxoplasma gondii and Mechanistic Insights into Transcript-Specific Translational Repression in the Bradyzoite Developmental Stage
... The MS2 loop aptamer consists of a small 19 nucleotide RNA hairpin that specifically binds that MS2 bacteriophage coat protein (CP) with dissociation constant of 3 x 10 -9 M (Said et al., 2009; Slobodin and Gerst, ...
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piRNA clusters and open chromatin structure
... Large fractions of eukaryotic genomes comprise trans- posable elements (TEs), which are repetitive DNA ele- ments that can mobilize to take up new chromosomal locations within a genome. TEs act as insertional muta- gens ...
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Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1
... noncoding RNA, Kcnq1ot1, regulates the expression of both ubiquitously and tissue-specific imprinted genes within the Kcnq1 ...Kcnq1ot1 RNA that mediate lineage-specific imprinting are ...by ...
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Differential expression of histone H3 genes and selective association of the variant H3.7 with a specific sequence class in Stylonychia macronuclear development
... synthesis, RNA was isolated from synchronized cells at several developmental stages, which corresponded to the time line (x-axis) as follows: 1) during vegetative growth phase; 2) from cells after conjugation, ...
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A Small-RNA Enhancer of Viral Polymerase Activity
... svRNAs function to promote full-length vRNA synthesis by the RdRp. As IAV produces svRNAs from cRNA (Fig. 1C), we next sought to investigate if svRNAs could act upon this template to modulate RdRp activity. To this end ...
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Biogenesis and Function of Small Non-Coding RNAs Derived from Eukaryotic Ribosomal RNA
... phasi RNA (rRF) pathway 4 Piwi RNA (rRF) pathway 3 5’ 3’ 3’ 5’ rDNA rRNA rRNA cleavage rRFs 5’ 3’ 3’ 5’ 5’ 3’ 3’ 3’ 5’. 18S 28S 45S rRNA mmu-miR-712 5.8S ITS1 ITS2 TIMP3 mRNA induce endo[r] ...
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Genome wide identification and characterization of transfer RNA derived small RNAs in Plasmodium falciparum
... active RNA inter- ference apparatus [18] and canonical miRNA molecules were found to be absent [19, 20], as confirmed by compu- tational and experimental ...small RNA biogenesis is thought to be either ...
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The mRNA bound proteome of the human malaria parasite Plasmodium falciparum
... functional RNA interference (RNAi) ma- chinery to regulate transcript ...the Piwi Argonaute Zwille (PAZ) and Piwi domains, found in proteins involved in RNAi, are absent or present at very low levels ...
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Analysis of the interaction of viral RNA replication proteins by using the yeast two-hybrid assay.
... viral RNA replication ...of RNA replication, and the protease-resistant structure has been found to be necessary for the binding of the 2a protein ...BMV RNA replication ...
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Comparison of the Catalytic Activities of Ricin A-Chain, Maize rproRIP1, MaizeRIP1, and Two Maize rproRIP1 Deletion Mutants Interacting with an RNA 10-mer GAGA Tetraloop.
... base-pairs (G-C or A-U) comprising the stem. They found that the GAGA sequence in the loop was an absolute requirement, but that neither the stem length (from seven to three base-pairs) nor the composition of the stem ...
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