PKA, cAMP-dependent PK
Regulation of the Gα-cAMP/PKA signaling pathway in cellulose utilization of Chaetomium globosum
... protein-cAMP/ PKA pathway in the transcriptional regulation of cellu- ...the cAMP-dependent PKA, using an established RNA interference (RNAi) strategy [30, ...intracellular cAMP ...
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Voltage-gated sodium channels dysfunction in depression: the hypothesis
... by cAMP-dependent PKA and PKC that could contribute to pathophysiology of ...as cAMP response element binding protein and brain derived neurotrophic factor which have the potential to increase ...
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Integration of Stress Responses: Modulation of Calcineurin Signaling in Saccharomyces cerevisiae by Protein Kinase A
... nase. PKA is an essential component of the general stress response in yeast and functions to coordinate metabolism, cell growth, and stress resistance with nutrient availability ...The PKA holoenzyme is a ...
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Using Substrate-Binding Variants of the cAMP-Dependent Protein Kinase to Identify Novel Targets and a Kinase Domain Important for Substrate Interactions in Saccharomyces cerevisiae
... variants were able to bind all substrates tested and showed no association with proteins that were not phosphory- lated by PKA. In addition, no significant binding was observed between substrates and the wild-type ...
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HIV 1 associated PKA acts as a cofactor for genome reverse transcription
... interactions with HIV-1 RT. This is illustrated by the cap- acity of the survival motor neuron (SMN)-interacting pro- tein 2 (Gemin2), an HIV-1-integrase binding protein, to enhance the assembly of RT on viral RNA in ...
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Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A
... (cAMP)- dependent protein kinase A ...of PKA, including ...activating PKA to enable filamentation in response to staurosporine through a mechanism that does not require degradation of the ...
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A Role for Lysosomal PH Dysfunction in Alzheimer’s Disease and Strategies for its Restoration
... with cAMP proved restorative, bringing lysosomal pH in PS1-fAD cells back to baseline while having minimal effect on control ...cells. cAMP increased Cat D active site availability, reduced autophagic ...
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Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A
... Since cAMP not only plays a key role in CFTR-dependent chloride transport [42] but also reg- ulates NDPK in vitro [43, 44], we investigated whether NDPK-B and CFTR might interact functionally in epithelia ...
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PKA R1 spatially restricts Oskar expression for Drosophila embryonic patterning
... of cAMP-dependent protein kinase (Pka-R1) as a key factor in the restriction of Oskar protein to the posterior ...from Pka-R1 germline clones show a duplication of the posterior structures, ...
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Protein Kinase A Contributes to the Negative Control of Snf1 Protein Kinase in Saccharomyces cerevisiae
... the PKA pathway. Collectively, our results suggest that PKA, which integrates multiple regulatory inputs, could contribute to Snf1 regulation under various condi- tions via a complex ...
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Regulation of the Subcellular Localization of Cyclic AMP-Dependent Protein Kinase in Response to Physiological Stresses and Sexual Differentiation in the Fission Yeast Schizosaccharomyces pombe
... pombe PKA regulatory and catalytic subunits are subcel- lularly redistributed in response to high ...of PKA regulatory and catalytic subunits is altered when cells are cultured in high-osmolarity ...pombe ...
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[HCO3-]-regulated expression and activity of soluble adenylyl cyclase in corneal endothelial and Calu-3 cells
... by cAMP, is mainly by PKA- dependent phosphorylation of the cyclic AMP response element binding (CREB) family of transcription factors (CREB, CREM, and ATF-1) ...
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Activating PRKACB somatic mutation in cortisol-producing adenomas
... vitro PKA activity assay with cell ...the PKA activity assay, expression of PKA subunits FLAG-Cβ, RIα, and RIIβ in cell lysates was determined by Western blot with specific antibodies (anti-FLAG ...
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Roles of CREB in the regulation of FMRP by group I metabotropic glutamate receptors in cingulate cortex
... with cAMP dependent kinase (PKA) com- pared to wild-type (WT) CREB [46,47], we found the upregulation of FMRP by stimulating Group I mGluR was enhanced compared to that of WT ...
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cAMP dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch independent manner
... endothelial PKA during sprouting angiogenesis is to restrain formation of tip ...whether PKA is (transiently) activated in tip cells and facilitates their transition to stalk cells, or whether it is ...
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Adeno-Associated Virus Type 2 Rep78 Inhibition of PKA and PRKX: Fine Mapping and Analysis of Mechanism
... of PKA and PRKX toward the artificial heptapeptide substrate referred to as kemptide (LRRASLG) ...inhibited PKA- and PRK-mediated phosphorylation of kemptide at levels comparable to those with full-length ...
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The role of PKAc1 in gene regulation and trichodimerol production in Trichoderma reesei
... The cAMP pathway represents one of the most impor- tant signaling checkpoints in living organisms, with protein kinase A being a central component of the signal transmission ...messenger cAMP, this pathway ...
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Tor and Cyclic AMP-Protein Kinase A: Two Parallel Pathways Regulating Expression of Genes Required for Cell Growth
... be dependent upon PKA catalytic ...on PKA components downstream of Ras and upstream of the Tpk catalytic ...crease cAMP levels in response to glucose, we can exclude models in which Tor ...
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The unsolved mystery of apoA-I recycling in adipocyte
... Besides, cAMP/PKA signaling regulates recycling of apoA-I by adipoctes, with the underlying mechanisms remain ...caveolae dependent process needs to be fur- ther ...
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N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling
... barrier; cAMP: Cyclic adenosine monophosphate; CCL2: Chemokine (C-C motif) ligand 2; CNS: Central nervous system; COX: Cyclooxygenase; CREB: cAMP response element binding protein; DAPI: 4 ′ ...
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