plasminogen activators
Support vector machine (SVM) based multiclass prediction with basic statistical analysis of plasminogen activators
... domain activators, since they have the functional capacity to convert plasminogen to active plasmin by cleaving the Arg-Val bond on the single-chain plasminogen to release two plasmin ...indirect ...
10
Effect of urokinase antiserum on plasminogen activators: demonstration of immunologic dissimilarity between plasma plasminogen activator and urokinase
... Antiserum against purified human urokinase was produced by immunization of Hartley strain guinea pigs. The antiserum was capable of neutralizing the plasminogen activator activity of the antigen and of native ...
17
Sites of synthesis of urokinase and tissue type plasminogen activators in the murine kidney
... Kidneys have long been recognized as a major source of plasminogen activators (PAs). However, neither the sites of synthesis of the enzymes nor their role in renal function have been elucidated. By the ...
10
Expression of plasminogen activators in preimplantation rat embryos developed in vivo and in vitro
... pregnancy. Plasminogen activators (PAs) have been implicated in mammalian fertilization, early stages of development and embryo ...(tPA) plasminogen activators in in vivo and in vitro ...
8
The Enzymatic Dissolution Of Experimental Arterial Thrombi in the Dog by Trypsin, Chymotrypsin and Plasminogen Activators
... Recent reports have appeared on the successful liquefaction of intravascular clots in rabbit ear veins by the intravenous infusion of large amounts of streptokinase 1; the lysis of venou[r] ...
12
The role of plasminogen activators in neoplasia and inflammatory lesions of the human intestine
... V CHAPTER 2 MATERIALS AND METHODS 37 CHAPTER 3 MONOCLONAL ANTIBODIES INHIBITORY TO 65 HUMAN PLASMIN: DEFINITIVE DEMONSTRATION OF A ROLE FOR PLASMIN IN ACTIVATING THE PROENZYME OF UROKINA[r] ...
226
Interaction between plasminogen activator inhibitor type 1 (PAI 1) bound to fibrin and either tissue type plasminogen activator (t PA) or urokinase type plasminogen activator (u PA) Binding of t PA/PAI 1 complexes to fibrin mediated by both the finger and the kringle 2 domain of t PA
... urokinase-type plasminogen activator (u-PA). This reaction is controlled by plasminogen activator inhibitor type 1 (PAI-1) that is either present in plasma or bound to fibrin, present in a ...activate ...
10
The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis
... the plasminogen acti- vation system (PAS) by pathogenic bacteria has received much ...activate plasminogen to enzymatically active plas- min with their endogenous plasminogen activators (PA) ...
8
Isolation from human plasma of a plasminogen activator identical to urinary high molecular weight urokinase
... plasmatic plasminogen activators (PA) can be demonstrated after sodium dodecyl sulfate polyacrylamide gel electrophoresis of plasma freshly collected from resting volunteers, followed by transfer of the ...
5
Observational study on pharmacoinvasive strategy and primary angioplasty in a tertiary care centre in acute myocardial infarction patients
... As compared to STK, administration of tissue plasminogen activators resulted in reduction of disabling stroke /death in nine out of one thousand patients treated, with a 0.2% absolute ex[r] ...
109
Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator
... Nebulized plasminogen activators conceptually offer great promise for the treatment of airway ...tissue plasminogen activa- tor (tPA; activase/alteplase, Genentech, San Francisco, CA) has previously ...
13
PLASMINOGEN ACTIVITY AND INHIBITORS IN NORMAL LATE PREGNANCY POSTPARTUM AND IN THE POSTNATAL PERIOD
... Plasminogen activators, measured in blood samples taken from pregnant women, show a definite dependence on the progression of pregnancy, increasing with gestation and returning to normal levels ...
15
Degradation of Human Fibrinogen by Plasma α2 Macroglobulin Enzyme Complexes
... of plasminogen activators to plasma induced an increase in the N-a-tosyl-l-arginine methyl ester HCl esterase and fibrinogenolytic activity associated with a 2 -macroglobulin purified from this plasma, ...
11
Fibrinolysis regulation by platelets retaining plasminogen and tissue-type plasminogen activator on their surface
... the plasminogen activation process on the surface of intact platelets and more than two times elevate the level of activation in the presence of thrombin-stimulated ...of plasminogen activation system ...
11
Study of the sites of plasminogen molecule which are responsible for inhibitory effect of Lys-plasminogen on platelet aggregation
... and plasminogen mediate their action through plasminogen-binding proteins on the cell ...possible plasminogen-binding proteins on the platelet ...studied plasminogen fragments (k1-3, k4 and ...
7
Fibrinogen Activates the Capture of Human Plasminogen by Staphylococcal Fibronectin Binding Proteins
... ABSTRACT Invasive bacterial pathogens can capture host plasminogen (Plg) and al- low it to form plasmin. This process is of medical importance as surface-bound plas- min promotes bacterial spread by cleaving ...
12
uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy
... The uPA gene (Gene ID: 5328; http://www.ncbi. nlm.nih.gov/) encodes a 411 amino acid serine protease that consists of two α and two anti-parallel β strands [19]. This protein is secreted as a zymogen (pro-uPA) that is ...
16
Modularity of eukaryotic transcription activators
... such activators work; provided a powerful tool for the analysis of other gene-activating and - repressing functions; laid the basis for the development of the two-hybrid system for detecting protein-protein ...
9
Elevated circulating PAI-1 levels are related to lung function decline, systemic inflammation, and small airway obstruction in chronic obstructive pulmonary disease
... Background: Plasminogen activator inhibitor-1 (PAI-1) and soluble urokinase-type plasminogen activator receptor (suPAR) participate in inflammation and tissue remolding in vari[r] ...
8
Arsenic Removal from Mine Tailings for Recycling via Flotation
... Figure 7 shows the arsenic concentration of the tails and the arsenic removal efficiency obtained during and after two subsequent scavenging tests. Here, it should be noted that similar optimization tests with the rougher ...
6