Platelet activation, aggregation and thrombus formation
Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries
... In the present study, there were no significant changes in blood pressure or heart rate during, or following, the intravenous (IV) administration of a-tocopherol, a-toco- trienol, or TRF. Importantly, however, the IV ...
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Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation
... of platelet activation and ...contact-dependent activation, thereby facilitating the activation of platelets and ...in platelet activation and throm- bosis positing that Axl or ...
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Thrombin initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model
... of platelet activation; and by monitoring platelet accu- mulation during thrombus formation in a living animal using multichannel intravital digital fluorescence ...model, ...
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Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
... to platelet activation was explored ...impaired platelet aggregation, fibrinogen binding, and granule secretion, especially in response to low concentrations of agonists that activate the G q ...
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Human mesenchymal stromal cells inhibit platelet activation and aggregation involving CD73-converted adenosine
... on platelet adhesion and aggregation under shear flow ...on platelet activation under shear flow conditions, we performed microfluidic experiments using a pneumatically driven channel system ...
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Ginsenoside F4 inhibits platelet aggregation and thrombus formation by dephosphorylation of IP 3 RI and VASP
... Introduction An area of damaged vascular wall activates platelets through a series of physiological molecules, such as ADP, thrombin, and collagen. Platelet aggregation is essential for the maintenance of ...
Platelet activation and aggregation after aneurysmal subarachnoid hemorrhage
... in platelet ac- tivation according to clinical severity based on Fisher classification [13], supporting the selection of patients for further ...of platelet anti-aggregants on DCI reduction in a context of ...
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PKCα regulates platelet granule secretion and thrombus formation in mice
... lating platelet secretion of α-granules, biogenesis and secretion of dense granules, regulation of integrin α IIb β 3 , and thrombus formation in vitro and in ...regulates platelet ...
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Investigating novel platelet immunoreceptor ‘CEACAM2’ in contact-dependent events that modulate platelet thrombus formation
... including platelet production (Chapter ...3 platelet abnormality existed in the CEACAM2 deficient ...normal platelet aggregation, platelet spreading and clot retraction functionality, ...
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Platycodin D inhibits platelet function and thrombus formation through inducing internalization of platelet glycoprotein receptors
... measuring platelet aggregation, activation, spreading, clot retraction, expression of glycoprotein ...inhibited platelet aggregation in response to collagen, ADP, arachidonic acid and ...
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Meizothrombin Preparation and Its Role in Fibrin Formation and Platelet Aggregation
... fibrin formation, platelet activation and ...pure. Platelet-rich plasma for aggregation study and gel-sieved platelets for flow-cytometry were separated from blood of healthy ...in ...
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Thrombus formation in vivo
... of thrombus morphol- ogy and pathology were followed by a period in which blood coagulation proteins were identified based on the character- ization of patients with hereditary clotting ...of platelet ...
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β3 phosphorylation of platelet αIIbβ3 is crucial for stability of arterial thrombus and microparticle formation in vivo
... Thus, platelet microparti- cles, which are highly active in thrombin generation and fibrin clot formation processes as well as in amplification of platelet aggregation, appear to contribute to ...
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Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques
... of platelet P2Y 12 in atherothrombosis, we used a recently established mouse model of acute plaque rupture ...non-occlusive thrombus formation ...induced platelet activation as well as ...
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Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen
... the formation of platelet plugs in ferric chloride–injured arterioles of live ...evaluated thrombus growth in mice lacking von Wille- brand factor (vWF) and fibrinogen (Fg), the two key ligands known ...
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Bile salt–dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans
... thrombin-mediated platelet aggregation, spreading, and activated α IIb β 3 ...and thrombus size was ...and thrombus formation were attenuated and tail bleeding times were increased in ...
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Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation
... of platelet aggrega- tion including the response to ...that activation of the EP3 receptor opposes the actions of the G s -coupled IP receptors in ...through activation of ...enhance platelet ...
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Reviews. Platelets As Immune Cells: Bridging Inflammation and Cardiovascular Disease In Vivo Thrombus Formation Platelet Adhesion
... its formation. Activation of platelets by thrombin is mediated by protease-activated receptors (PARs), 32 which couple to G q , G 12 /G 13 and, in some cases, also to the G i family of heterotrimeric G ...
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A revised model of platelet aggregation
... of platelet aggregation under physiological flow con- ditions using an in vitro flow-based platelet aggregation assay and an in vivo rat thrombosis ...the platelet aggregation ...
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Interrelations of Platelet Aggregation and Secretion
... and aggregation appeared to be parallel ...behind aggregation, secretion was dependent upon aggregation and was inhibited by indomethacin; this is referred to as aggregation-mediated ...
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