Platelet-Derived Growth Factor alpha
Chrysotile asbestos upregulates gene expression and production of alpha receptors for platelet derived growth factor (PDGF AA) on rat lung fibroblasts
... PDGF-R alpha, blocked the PDGF binding sites that were upregulated by fiber ...PDGF-R alpha population on RLF without significant change in PDGF-R ...
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Platelet Rich Plasma Intra Articular Injection for Chronic Synovitis Treatment in Patients with Haemophilia One Year Follow Up
... [5]. Platelet-rich plasma (PRP) is used to stimulate healing of the joint and provide symptomatic relief ...contains alpha-granules with growth factors and proteins used in joint homeostasis, healing ...
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Olaratumab: a platelet-derived growth factor receptor-α-blocking antibody for the treatment of soft tissue sarcoma
... Grade 3/4 adverse events occurred more frequently in the doxorubicin and olaratumab arm (38/42%) than the doxorubicin- alone arm (38/31%), and doxorubicin-associated adverse events were more frequent in the combination ...
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Immunolocalization of platelet‐derived growth factor receptor‐β (PDGFR‐β) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
... muscle alpha-actin (SMA, 1:500, Clone 1A4, Dako, Cambridge, UK), anti-Notch-3 extracellular domain (N3ECD, A1-1 at 1:10 000), glucose transporter-1 (GLUT-1, 1:200, PA1-21041 Thermo Scientific, Rockford, IL, ...
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Olaratumab in soft tissue sarcoma - Current status and future perspectives.
... against platelet-derived growth factor receptor alpha (PDGFR a ), to doxorubicin confers an unprecedented improvement in overall survival to pa- tients with anthracycline-naı¨ve ...
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Type H blood vessels in bone modeling and remodeling
... secreted growth factors to promote osteoprogenitor survival and ...PDGF-BB, platelet-derived growth factor-type BB; SLIT3, slit homolog 3 protein; HIF-1α, hypoxia-inducible ...
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Structural analysis of platelet-derived growth factor receptor alpha by protein homology modeling
... Elling, C., Erben, P., Walz, C., Frickenhaus, M., Schemionek, M., Stehling, M., Serve, H., Cross, N. C. P., Hochhaus, A., Hofmann, W.-K., Berdel, W. E., Müller-Tidow, C., Reiter, A. and Koschmieder, S. (2011). Novel ...
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Function and regulation of Platelet-Derived Growth Factor Receptor Alpha during development
... Active PDGF is composed of dimers of A and B chains. All three dimeric isoforms of PDGF (AA, AB, BB) can bind to and activate PDGFRa in vitro. It is generally thought that, of these, PDGF-AA is the major ligand for PD G ...
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Antiangiogenic effects in patients with progressive desmoplastic small round cell tumor: data from the French national registry dedicated to the use of off-labeled targeted therapy in sarcoma (OUTC’s)
... endothelial growth factor receptors (VEGFR) 1–3, c-KIT, and the platelet-derived growth factor receptors (PDGFR) alpha and beta, and has been approved for advanced soft ...
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Effects of platelet derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat storing cells
... of growth curves revealed a similar pattern of potency of the growth ...other growth factors together with PDGF by inflammatory cells represents a potent potential stimulus for FSC proliferation in ...
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Platelet-rich plasma stimulates angiogenesis in mice which may promote hair growth
... the alpha granules in platelets, PRP can secrete various growth factors, including platelet-derived growth fac- tor (PDGF), vascular endothelial growth factor (VEGF), ...
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Neovascular age-related macular degeneration: intraocular inflammatory cytokines in the poor responder to ranibizumab treatment
... cytokine/Angiogenesis/Growth factor and a Cardiovascular Magnetic Bead Panel Immunology Multiplex assay (EMD Millipore, Billerica, MA, ...IL-17A, platelet-derived growth ...
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Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis
... the platelet-derived growth factor (PDGF)/PDGF receptor pathway is thought to play a critical role in fibrogenesis of the ...Other growth factors, including fibroblast growth ...
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Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers
... cell growth, proliferation, survival, and motility, and also regulate the epithelial – mesenchymal transi- tion (EMT) with a strong impact on the development of metas- ...
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<p>Treatment of recurrent myopic macular hole using membrane of plasma rich in growth factors</p>
... In our case report, we describe a patient with myopic MH, who had not responded to PPV surgery with ILM peeling; a second surgery was carried out with an extension of the ILM peeling margins, and with a PRGF membrane ...
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Neuron Like Differentiation of Bone Marrow Derived Mesenchymal Stem Cells
... Although all the groups showed expression of the gene in the case of GFAP, the group with growth factor only showed increased expression of the gene. For NSE, the control group was expressed minutely. NSE ...
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Expressions of Growth Factors in Autologous Derived Platelet-Rich Plasma and Platelet-Poor Plasma; Implication for Tissue Reparation and Wound Healing
... the platelet count from the PRP were weak, this might be due to small sample size, or might be due to isolated incidents of inefficient concentration of ...the platelet concentration process is reliable by ...
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Caries Induced FGF 2 Expression in Human Dental Pulp
... regulatory factor in the control of vascular permeability and angiogenesis (Ferrara et ...endothelial growth factor is originally a basic 45-kDa heparin-binding ...and Platelet derived ...
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Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential
... bone-marrow derived MSCs contribute to tissue remodeling after injury ...EVs derived from ASCs that may represent a suitable source of adult stem cells for regenerative medi- ...angiogenic growth ...
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Growth factors in idiopathic pulmonary fibrosis: relative roles
... atinocyte growth factor, a mitogen and differentiation growth factor for type II AECs, has been found to have a protective effect against development of fibrosis in animal models of ...
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