Platinum-‐based anticancer drugs
Towards an Understanding of Specific Response of Metallothionein (Sub)Isoforms to Exposure to Platinum-Based Anticancer Drugs
... The increase of MTs’ presence in malignant cells can therefore rapidly bind the applied cisplatin. This mechanism results in the decrease of the drug concentration below the effective level. Thus, MTs can inhibit the ...
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Approaches to the Search of Platinum Anticancer Agents: Derivatizing Current Drugs and Incorporating HDAC Inhibition
... 1, platinum-based anticancer drugs, such as cisplatin, carboplatin, and oxaliplatin, have been approved for worldwide clinical use for ...of platinum-based anticancer ...
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Tryptophan switch for a photoactivated platinum anticancer complex
... The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are widely used in the clinic, but they are untargeted, and their use is often accompanied by side e ff ...the ...
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Diazido platinum(IV) complexes for photoactivated anticancer chemotherapy
... other platinum-based anticancer drugs. 5,6 Platinum drugs are now used to treat over 40% of all cancer patients in chemotherapy since cisplatin was approved by FDA in 1978 to ...
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SYNTHESIS AND CHARACTERIZATION OF ANTICANCER DRUGS BASED ON PLATINUM
... For example, unlike cisplatin, oxaliplatin in plasma rapidly undergoes non-enzymatic transformation into reactive compounds because of displacement of the oxalate group, a process that complicates its pharmacokinetic ...
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The prediction of Raman spectra of platinum(ii) anticancer drugs by density functional theory
... 2. Theoretical method The calculation of Raman intensities is based on PlaczekÕs polarizability theory [23]. It should be noted that the theoretical values are obtained within the dou- ble harmonic approximation, ...
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Platinum anticancer drug shortages
... of platinum metal is very high. In June 2019 the spot price of platinum was US$814 per ounce, which is more than 50 times higher than the price of silver, but only 58% the cost of ...However, based ...
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Linear and non-linear QSAR models on platinum (II) anticancer drugs with N-donor ligands
... The number of descriptors was then reduced through an objective feature selection in three steps. At first, descriptors that had the same value for at least 70% of compounds in the dataset were removed. In the next step, ...
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MRI-detectable polymeric micelles incorporating platinum anticancer drugs enhance survival in an advanced hepatocellular carcinoma model
... not provide satisfactory contrast for the accurate diagnosis of hepatic lesions, especially small tumors. This is because the enhancement pattern depends on the structural properties of cells and tissues, such as the ...
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Cucurbit[n]uril binding of platinum anticancer complexes
... and based upon the similarity of the chemical shifts of the bound metal complex, it can be concluded that the cucurbituril was positioned in a similar fashion to the Cl form of ...a platinum centre passing ...
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In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds
... of platinum complexes with DCA in a range of different cell lines, including HEK293 normal epithelial kidney ...selected platinum-based drugs, such as carboplatin, satraplatin, and its main ...
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Computer aided drug design of photoactivated platinum anticancer complexes
... 1960s, platinum-based drugs have been widely used against various ...Pt anticancer drugs to make chemotherapy safer for patients, in particular, lessening severe side effects, 142,143 ...
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Current Status for Oral Platinum (IV) Anticancer Drug Development
... chemotherapeutic drugs such as cisplatin, carboplatin and oxaliplatin are widely applied for the treatment of various types of ...clinical platinum drugs. Platinum (IV) complexes are one of ...
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Novel perspective of anticancer metal-based drugs: Characteristics of heterometallic complexes and their potential applications
... Abstract: Platinum-based drugs are widely use in medical treatments, but their effectiveness is limited by ...of platinum (soft acid) with biomolecules, which contain sulfur as donor atom ...
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The new platinum-based anticancer agent LA-12 induces retinol binding protein 4 in vivo
... of platinum-based drugs such as satraplatin ((OC-6-43)-bis (acetato)amminedichloro(cyclohexylamine)platinum(IV)), known also as JM216, the first orally administered plati- num compound ...
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Anticancer Drugs
... d. It is a useful drug for induction of remission in acute lymphoblastic leukemia (c) 68. A patient with cancer developed extreme degree of radiation toxicity. Further history revealed that the dose adjustment of a ...
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Photoactivatable platinum (IV) anticancer complexes
... DFT-TDDFT calculations performed on the complex trans, trans, trans- [Pt(N 3 ) 2 (OH)(Succ)(pyr) 2 ] showed dissociative transitions at longer wavelength, which could explain the photolability observed in these ...
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Pricing in the market for anticancer drugs
... prolonging drugs that are deemed not ‘cost effective’… The result, studies show, is that Great Britain’s cancer survival rates are among the worst in Europe and lag behind the United ...
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RECENT ADVANCES IN ANTICANCER DRUGS
... and anticancer. Anticancer drugs exploit quantitative differences between the host and cancer cells and adverse reactions to anticancer drugs are often caused by the death of normal ...
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New platinum and palladium complexes: their anticancer application
... compounds. Platinum complexes can, for example, be attached to doxorubicin, an anthracycline antibiotic which intercalates DNA and is commonly used in the treatment of various types of ...cancer. Platinum ...
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