pleiotropic effects
The Pleiotropic Effects of Beneficial Mutations of Adapted Escherichia coli Populations
... Additionally, NAG is taken into the cytosol via the phosphate transferase system and it is here that mutations would most likely have the largest effect. Mutations affecting the rate or efficiency of glucose uptake via ...
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Ongoing clinical trials of the pleiotropic effects of statins
... noncardiovascular pleiotropic effects of statins in humans (Table ...Since pleiotropic effect is defined here, as it should, as “multiple effects” of a drug, there is no attempt in this review ...
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The pleiotropic effects of the glutamate dehydrogenase (GDH) pathway in Saccharomyces cerevisiae
... The pleiotropic effects of GDH pathway in yeast biology highlight the importance of glutamate homeostasis in vital cellular processes and reveal new features for conserved enzymes that were primarily ...
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Mutations That Determine Resistance Breaking in a Plant RNA Virus Have Pleiotropic Effects on Its Fitness That Depend on the Host Environment and on the Type, Single or Mixed, of Infection
... that pleiotropic effects on virus multiplication of host range mutations depend on the spe- cific mutation and on the specific susceptible ...always pleiotropic on fitness, and when they are, ...
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Pleiotropic effects of statins in atrial fibrillation patients: the evidence
... beneficial effects of statins on AF have been reported in several ...positive effects of statins on the burden of AF appeared to be independent of their cholesterol-reducing ...statins, pleiotropic ...
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Multivariate mutation-selection balance with constrained pleiotropic effects.
... In terms of quantitative genetic theory this means that the possi- ble pleiotropic effects of quantitative genetic variation are most often not changed by mutations at [r] ...
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Pleiotropic effects of the HMG-CoA reductase inhibitors
... The pleiotropic effects of statins are attributed to several processes resulting from the inhibition of HMG-CoA reductase. The main effect of statins is the inhibition of cholesterol and isoprenoid ...
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Pleiotropic effects of rosuvastatin on microvascular function in type 2 diabetes
... Abstract: Rosuvastatin is known to reduce low-density lipoprotein (LDL)-cholesterol and improve endothelial function. In addition to lipid-lowering, statins may exert pleiotropic (nonlipid lowering) effects ...
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The pleiotropic effects of dexamethasone on breast cancer cell behaviour
... tumour growth in xenografts of human breast cancer cells in mice. Without corroborating data (i.e., they observed no change in Ki-67 levels in Dex treated cells), Pang et al suggested that the difference in tumour sizes ...
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Pleiotropic effects and pharmacological properties of penehyclidine hydrochloride
... Results: PHC can effectively antagonize the symptoms of central and peripheral poisoning caused by organophosphorus poisoning. As a preanesthetic medication, it can not only effectively reduce mucus secretion and ...
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Pleiotropic effects of mutants in gene A of bacteriophage phi chi 174.
... The differential ability of the gene A mutants studied in this report to terminate cellular DNA replication and to kill the host cell suggests that both products are functional and that [r] ...
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ANALYSIS OF PLEIOTROPIC EFFECTS OF W AND f GENIC SUBSTITUTIONS IN THE MOUSE
... versus +/+ genic substitution has no significant effect on body growth.-Both f/f versus f/+ genic substitution, and W / + versus +/+ genic substitution, lead to a moder[r] ...
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PLEIOTROPIC EFFECTS ON FITNESS OF MUTATIONS AFFECTING VIABILITY IN DROSOPHILA MELANOGASTER
... Therefore, we conclude that the effects of hybrid dysgenesis that are likely to have occurred in the viability tests would also have occurred in the fitness tests, thereby casti[r] ...
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Positive pleiotropic effects of HMG-CoA reductase inhibitor on vitiligo
... Interestingly, the use of lipid lowering agent, specifically HMG-CoA reductase inhibitors, has been reported to have immunosuppressive effects in a study of heart transplant recipients [14]. The drug-induced ...
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Pleiotropic effects of fenofibrate therapy on rats with hypertriglycemia
... the effects of fenofribate therapy on hypertriglycemia, endothelial function and systemic in- flammation and oxidation, different doses of fenofibrate, named low- and high-dose (LFF and HFF), were prescribed for 2 ...
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Pleiotropic effects of antithrombin strand 1C substitution mutations
... Six different substitution mutations were identified in four different amino acid residues of antithrombin strand 1C and the polypeptide leading into strand 4B F402S, F402C, F402L, A404T[r] ...
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A NOS1 variant implicated in cognitive performance influences evoked neural responses during a hight density EEG study of early visual perception
... A critical question for cognitive neuroscience regards how individual genes contribute to variation in cognitive function. Among several possibilities (e.g., impact on grey matter volume, white matter structure, white ...
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The phenotypic plasticity of developmental modules
... affects both the melanic bands and the wing size or shape. Wnt signaling has also been implicated in the regulation of the bands of the nymphalid ground plan symmetry sys- tem, which also tend to be more robust to ...
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Molecular Basis of the Pleiotropic Phenotype of Mice Carrying the hypervariable yellow (Ahvy) Mutation at the agouti Locus
... In addition to controlling coat color, dominant yellow alleles at the agouti locus are associated with a number of pleiotropic effects in- cluding adult-onset obes[r] ...
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Statins and Sepsis: Possible Connections and Therapeutic Implications
... exhibit pleiotropic effects independent of lipid lowering, encompassing antiinflammatory, immunomodulatory, antiapoptic and antithrombotic ...adverse effects associated with statin use in critically ...
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