Polygenic risk scores
Associations between polygenic risk scores for four psychiatric illnesses and brain structure using multivariate pattern recognition
... relate polygenic risk scores (PRS) – a measure of the overall genetic risk an individual carries for a disorder – to brain structure using univariate ...
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Potential use of clinical polygenic risk scores in psychiatry – ethical implications and communicating high polygenic risk
... predict risk. Psychiatric disorders are highly heritable, but also polygenic, with genetic risk conferred by interactions between thousands of variants of small effect that can be summarized in a ...
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Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.
... their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and pre- vention ...lifetime risk of overall breast cancer in the top centile of the PRSs was ...
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Associations between polygenic risk scores for four psychiatric illnesses and brain structure using multivariate pattern recognition
... relate polygenic risk scores (PRS) – a measure of the overall genetic risk an individual carries for a disorder – to brain structure using univariate ...
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Polygenic risk scores in imaging genetics: Usefulness and applications
... increased risk for both ...or polygenic architecture of psychiatric disorders as the amount of phenotypic variation explained by each GWAS-supported SNP is small whereas the number of SNPs/regions ...
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Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes
... their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and pre- vention ...lifetime risk of overall breast cancer in the top centile of the PRSs was ...
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Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers.
... University Medical Center Utrecht, NL: M. G. E. M. Ausems, R. B. van der Luijt, C. C. van der Pol; Amsterdam Medical Center, NL: C. M. Aalfs, T. A. M. van Os; VU University Medical Center, Amsterdam, NL: J. J. P. Gille, ...
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Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores.
... Association Analyses. We evaluated associations of SNPs with risks of breast and prostate cancer simultaneously using multinomial logistic regression. The control group in this analysis was de fi ned as the set of samples ...
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Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5
... a risk factor for degenerative disease at the hip 11,12,23 , and osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis 15,24,25 ...replacement. Polygenic ...
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Exceptional longevity and polygenic risk for Cardiovascular Health
... their polygenic risk scores (PRS) based on a genome wide association study (GWAS) threshold of p < 5 × 10 −5 ...cardiovascular-related risk factors (lipids) and disease (myocardial ...
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Polygenic risk of ischemic stroke is associated with cognitive ability
... stroke polygenic risk scores and the cognitive phenotypes described ...the risk score, and 4 multidimensional scaling ...ability scores, and measures of crystallized cognitive ability ...
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Search | Preprints
... (MDD) polygenic risk scores (PRS). The polygenic risk scores are represented in the gradient scales, meanwhile in the x-axis the global ancestry PCA1 and in the y-axis the global ...
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Are genetic risk factors for psychosis also associated with dimension-specific psychotic experiences in adolescence?
... disorder polygenic risk scores (PRS), as well as specific single nucleotide polymorphisms (SNPs) previously identified as risk variants for schizophrenia, were associated with adolescent ...
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Recent quantitative genetic research on psychotic experiences: new approaches to old questions
... schizophrenia-associated risk allele (rs17512836, in TCF4) was significantly associ- ated with higher quantitative scores on a paranoia scale in the general population at age 16 [20 ...]. Polygenic ...
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Polygenic risk score for predicting weight loss after bariatric surgery
... Cost-effectiveness analysis of polygenic risk scores. In order to test whether the potential improvements of the predictive power observed after the inclusion of polygenic risk ...
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Common polygenic variation can predict risk of Alzheimer’s disease
... known genome-wide significant SNPs. To investigate this possibility we repeated our analysis using identical analysis thresholds but excluding all 5,006 SNPs that, after LD pruning, were present at the 24 genomic regions ...
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Assessing the incremental contribution of common genomic variants to melanoma risk prediction in two population-based studies
... environmental) risk factors overlap in their prediction of melanoma ...traditional risk factors, using data from two population-based case-control studies from Australia (n ¼ 1,035) and the United Kingdom ...
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Migraine polygenic risk score associates with efficacy of migraine-specific drugs
... generate polygenic risk scores (PRSs), which includes the additive effect of all variants of the ...disease risk pre- diction, 3 identifying and quantifying comorbidities and endophenotypes, 4 ...
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Are genetic risk factors for psychosis also associated with dimension specific psychotic experiences in adolescence?
... future polygenic risk scores that explain larger proportions of the liability to schizophrenia and bipolar ...work, polygenic risk scores will hopefully offer the opportunity to ...
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Impact of a panel of 88 SNPs on the risk of breast cancer in high risk women: Results from two randomised tamoxifen prevention trials
... elevated risk of cancer, and it appears that recalibration of polygenic risk scores is needed for these ...and risk because risks for each SNP are different for BRCA1/2 mutation ...
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