Polypyrimidine tract
Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements.
... Efficient expression of human T-cell leukemia virus (HTLV) and human immunodeficiency virus structural proteins requires Rex and Rev proteins, respectively. Decreased expression of Gag and Env appears to be due, in part, ...
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Attenuating mutations in the poliovirus 5' untranslated region alter its interaction with polypyrimidine tract-binding protein.
... Mutations in the 5 * untranslated regions (5 * -UTRs) of all three serotypes of the Sabin vaccine strains are known to be major determinants of the attenuation phenotype. To further understand the functional basis of the ...
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Polypyrimidine Tract-Binding Protein Binds to the Leader RNA of Mouse Hepatitis Virus and Serves as a Regulator of Viral Transcription
... is polypyrimidine tract-binding protein (PTB) (also known as heterogeneous nuclear ribonucleoprotein [hnRNP] I), a nuclear protein which shuttles between the nucleus and ...
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A 57-Nucleotide Upstream Early Polyadenylation Element in Human Papillomavirus Type 16 Interacts with hFip1, CstF-64, hnRNP C1/C2, and Polypyrimidine Tract Binding Protein
... and polypyrimidine tract binding protein, suggesting that these factors were either enhancing or regulating polyadenylation at the HPV-16 early polyadenylation ...
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Original Article Inhibition of hepatitis B virus in HepG2.2.15 by indirubin through suppression of a polypyrimidine tract-binding protein
... Abstract: Chronic hepatitis B virus (HBV) infection continues to be a public health burden worldwide. With the current treatment strategy, a limited number of patients achieve “functional cure”. There is a need for novel ...
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Interaction of HIV 1 integrase with polypyrimidine tract binding protein and associated splicing factor (PSF) and its impact on HIV 1 replication
... protein, polypyrimidine tract bind- ing protein and associated splicing factor (PSF) through pull down assay and co immunoprecipitation of IN with mammalian cell ...
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Specific interaction of polypyrimidine tract-binding protein with the extreme 3'-terminal structure of the hepatitis C virus genome, the 3'X.
... We previously identified a highly conserved 98-nucleotide (nt) sequence, the 3 * X, as the extreme 3 * -terminal structure of the hepatitis C virus (HCV) genome (T. Tanaka, N. Kato, M.-J. Cho, and K. Shimotohno, Biochem. ...
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Polypyrimidine Tract Binding Protein Induces Human Papillomavirus Type 16 Late Gene Expression by Interfering with Splicing Inhibitory Elements at the Major Late 5′ Splice Site, SD3632
... pMT1, pMT2, and pMT3 were constructed by the cleaving of pT1, pT2, and pT3 with SalI and BssHII, the filling in of overhangs, and religation. pMT22 was constructed by the cleaving of pT2 with SalI and MluI, the filling ...
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Polypyrimidine Tract-Binding Protein Binds to the Complementary Strand of the Mouse Hepatitis Virus 3′ Untranslated Region, Thereby Altering RNA Conformation
... the polypyrimidine tract-binding protein (PTB, also known as heterogeneous nuclear RNP I) by immunoprecipitation of the UV-cross-linked protein and binding of the recombinant ...
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Functional Analysis of RNA Structures Present at the 3′ Extremity of the Murine Norovirus Genome: the Variable Polypyrimidine Tract Plays a Role in Viral Virulence
... single-stranded polypyrimidine tract [p(Y)] of variable length between MNV isolates, within the terminal stem-loop ...p(Y) tract were viable both in cell culture and upon mouse infection, demon- ...
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Branchpoint and polypyrimidine tract mutations mediating the loss and partial recovery of the Moloney murine sarcoma virus MuSVts110 thermosensitive splicing phenotype.
... the polypyrimidine tract in this avian ret- rovirus as well ...MuSVts110 polypyrimidine tract caused a striking increase in splicing efficiency and lessening of splicing thermosensitivity that ...
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Expression analysis of the polypyrimidine tract binding protein (PTBP1) and its paralogs PTBP2 and PTBP3 during Xenopus tropicalis embryogenesis
... which is consistent with data previously reported in X. laevis (Tamanoue et al., 2010), At the early tailbud stage (stage 25, Fig. 3A panel e), in addition to the strong epidermal signal, an enhanced expression was ...
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Functional Significance of the Interaction of Hepatitis A Virus RNA with Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH): Opposing Effects of GAPDH and Polypyrimidine Tract Binding Protein on Internal Ribosome Entry Site Function
... and polypyrimidine tract binding protein (PTB) bind to overlapping sites in stem-loop IIIa of the internal ribosome entry site (IRES) of Hepatitis A virus (HAV), a ...
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Hepatitis C Virus Internal Ribosome Entry Site-Dependent Translation in Saccharomyces cerevisiae Is Independent of Polypyrimidine Tract-Binding Protein, Poly(rC)-Binding Protein 2, and La Protein
... Most eukaryotic mRNAs are translated by a 5 ⬘ -end-depen- dent mechanism, involving recruitment of the 40S ribosomal subunit by a series of interactions organized around the cap- binding protein eIF4E and the 5 ⬘ -cap ...
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Functional involvement of polypyrimidine tract-binding protein in translation initiation complexes with the internal ribosome entry site of foot-and-mouth disease virus.
... The synthesis of picornavirus polyproteins is initiated cap independently far downstream from the 5 * end of the viral RNA at the internal ribosome entry site (IRES). The cellular polypyrimidine ...
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Hypoxia May Increase Rat Insulin mRNA Levels by Promoting Binding of the Polypyrimidine Tract-binding Protein (PTB) to the Pyrimidine-rich Insulin mRNA 3′-Untranslated Region
... We recently demonstrated that insulin mRNA is highly abundant and constitutes up to 30% of the pancreatic beta cell mRNA (1). The insulin mRNA is also especially long-lived, 29–77 hr, depending on glucose concentration ...
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The Polypyrimidine Tract-Binding Protein Affects Coronavirus RNA Accumulation Levels and Relocalizes Viral RNAs to Novel Cytoplasmic Domains Different from Replication-Transcription Sites
... information. Polypyrimidine tract-binding protein (PTB) was reproducibly identified in association with positive-sense RNAs of transmissible gastroenteritis coronavirus (TGEV) TRS-L and TRS-B by affinity ...
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Interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation.
... of polypyrimidine tract-binding protein (PTB) at three distinct regions within the 5 * NCR by UV cross-linking ...consensus polypyrimidine tract ...
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The Polypyrimidine Tract Binding Protein Is Required for Efficient Picornavirus Gene Expression and Propagation
... the polypyrimidine tract binding protein, and test its requirement in picornavirus gene expression and ...midine tract binding protein resulted in a marked delay of particle propagation and ...
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HuR Displaces Polypyrimidine Tract Binding Protein To Facilitate La Binding to the 3′ Untranslated Region and Enhances Hepatitis C Virus Replication
... HuR Displaces Polypyrimidine Tract Binding Protein To Facilitate La Binding to the 3= Untranslated Region and Enhances Hepatitis C Virus Replication Shivaprasad Shwetha, Anuj Kumar, Rana[r] ...
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