Polypyrimidine tract-binding protein
Polypyrimidine Tract-Binding Protein Binds to the Complementary Strand of the Mouse Hepatitis Virus 3′ Untranslated Region, Thereby Altering RNA Conformation
... major protein species, p55, was identified as the polypyrimidine tract-binding protein (PTB, also known as heterogeneous nuclear RNP I) by immunoprecipitation of the UV-cross-linked ...
7
The Polypyrimidine Tract Binding Protein Is Required for Efficient Picornavirus Gene Expression and Propagation
... the polypyrimidine tract binding protein, and test its requirement in picornavirus gene expression and ...midine tract binding protein resulted in a marked delay of ...
8
A 57-Nucleotide Upstream Early Polyadenylation Element in Human Papillomavirus Type 16 Interacts with hFip1, CstF-64, hnRNP C1/C2, and Polypyrimidine Tract Binding Protein
... hFip1 protein, which has been shown to enhance polyadenylation through U-rich upstream elements, interacted specifically with the HPV-16 upstream ...and polypyrimidine tract binding ...
19
Expression analysis of the polypyrimidine tract binding protein (PTBP1) and its paralogs PTBP2 and PTBP3 during Xenopus tropicalis embryogenesis
... (polypyrimidine tract binding protein) family of RNA-binding proteins plays a critical role in development through the regulation of post-transcriptional ...
8
Functional involvement of polypyrimidine tract-binding protein in translation initiation complexes with the internal ribosome entry site of foot-and-mouth disease virus.
... The synthesis of picornavirus polyproteins is initiated cap independently far downstream from the 5 * end of the viral RNA at the internal ribosome entry site (IRES). The cellular polypyrimidine ...
10
Hepatitis C Virus Internal Ribosome Entry Site-Dependent Translation in Saccharomyces cerevisiae Is Independent of Polypyrimidine Tract-Binding Protein, Poly(rC)-Binding Protein 2, and La Protein
... cap- binding protein eIF4E and the 5 ⬘ -cap structure of the ...internal binding of the 40S ribosomal subunit to an internal ribosome entry site (IRES) ...La protein (3), polypyrimidine ...
12
Polypyrimidine Tract Binding Protein Induces Human Papillomavirus Type 16 Late Gene Expression by Interfering with Splicing Inhibitory Elements at the Major Late 5′ Splice Site, SD3632
... encoding polypyrimidine tract binding protein (PTB) was first PCR amplified with oligonucleotides PTBaS and PTBaA (Table 1) and cloned into ...
14
Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements.
... by binding of specific cellular ...is polypyrimidine tract-binding protein or hnRNP ...A1 binding site in U5 RNA and demonstrated that p40CRS (hnRNP A1) binding to that ...
7
Specific interaction of polypyrimidine tract-binding protein with the extreme 3'-terminal structure of the hepatitis C virus genome, the 3'X.
... 57-kDa protein (p57), which had higher affinities to RNA probes, recognized a 26-nt sequence including the 5 * -terminal 19 nt of the 3 * X and 7 flanking nt, designated the transitional ...consensus ...
7
Functional Significance of the Interaction of Hepatitis A Virus RNA with Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH): Opposing Effects of GAPDH and Polypyrimidine Tract Binding Protein on Internal Ribosome Entry Site Function
... and polypyrimidine tract binding protein (PTB) bind to overlapping sites in stem-loop IIIa of the internal ribosome entry site (IRES) of Hepatitis A virus (HAV), a ...the binding of ...
10
Original Article Inhibition of hepatitis B virus in HepG2.2.15 by indirubin through suppression of a polypyrimidine tract-binding protein
... Abstract: Chronic hepatitis B virus (HBV) infection continues to be a public health burden worldwide. With the current treatment strategy, a limited number of patients achieve “functional cure”. There is a need for novel ...
8
Attenuating mutations in the poliovirus 5' untranslated region alter its interaction with polypyrimidine tract-binding protein.
... Mutations in the 5 * untranslated regions (5 * -UTRs) of all three serotypes of the Sabin vaccine strains are known to be major determinants of the attenuation phenotype. To further understand the functional basis of the ...
8
Polypyrimidine Tract-Binding Protein Binds to the Leader RNA of Mouse Hepatitis Virus and Serves as a Regulator of Viral Transcription
... cellular protein, previously described as p55, binds specifically to the plus strand of the mouse hepatitis virus (MHV) leader ...this protein and determined by partial peptide sequencing that it is ...
6
Interaction of HIV 1 integrase with polypyrimidine tract binding protein and associated splicing factor (PSF) and its impact on HIV 1 replication
... interacting protein of HIV-1 IN, to understand the mech- anism of it’s action in HIV-1 replication and subsequent development of new therapeutic ...multifunctional protein PSF interaction with HIV-1 IN and ...
18
HuR Displaces Polypyrimidine Tract Binding Protein To Facilitate La Binding to the 3′ Untranslated Region and Enhances Hepatitis C Virus Replication
... bait protein and incubated with replicon cell lysates, followed by Western blotting with anti-NS5B ...The binding of RNA to a protein often influences its interaction with other pro- teins by ...
17
The Polypyrimidine Tract-Binding Protein Affects Coronavirus RNA Accumulation Levels and Relocalizes Viral RNAs to Novel Cytoplasmic Domains Different from Replication-Transcription Sites
... between protein complexes that mediate exon definition (10, 33) or, alternatively, by precluding the association of splicing factors (17, 64, ...The binding of PTB to viral RNA may promote RNA-RNA or ...
14
Hypoxia May Increase Rat Insulin mRNA Levels by Promoting Binding of the Polypyrimidine Tract-binding Protein (PTB) to the Pyrimidine-rich Insulin mRNA 3′-Untranslated Region
... the protein PTB. This binding seems to be involved in regulation of insulin mRNA stability, and can be enhanced by glucose and reducing compounds ...PTB binding to the ins- PRS was stimulated in ...
10
Interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation.
... rRNA binding site has also been localized between nt 192 and 203 of HCV 5 9 ...ribosome binding, and facilitating direct binding of ribosomes and other factors by modulating the structure of the IRES ...
9
Role of Polypyrimidine Tract Binding Protein in the Function of the Hepatitis B Virus Posttranscriptional Regulatory Element
... smaller protein was identified as GAPDH (40), whose role in PRE function is as yet ...PRE binding protein is PTB, a well-known RNA binding nuclear ...
8
Cleavage of Poly(A)-Binding Protein by Poliovirus 3C Proteinase Inhibits Viral Internal Ribosome Entry Site-Mediated Translation
... include polypyrimidine tract-binding protein (PTB) (26, 50), poly r(C)-binding protein 2 (PCBP2) (9, 10), lupus autoantigen (La) (44), and upstream of N-ras (Unr) ...multiple ...
11