PON1 Gene
Interaction between prenatal pesticide exposure and a common polymorphism in the PON1 gene on DNA methylation in genes associated with cardio-metabolic disease risk—an exploratory study
... the PON1 gene substitutes glutamine (Q) to arginine (R) at position ...the PON1 Q192R genotype was deter- mined in the ...the PON1 Q192R ...the PON1 192R-allele [20]. Thus, the obtained ...
19
Two common nonsynonymous paraoxonase 1 (PON1) gene polymorphisms and brain astrocytoma and meningioma
... whether PON1 genotype and allelic variants could be related to the risk of developing brain astrocytoma and/or meningioma, we have compared the prevalence of the PON1 -L55M and PON1 - Q192R poly- ...
7
Genetic Association Analysis of Human Longevity in Cohort Studies of Elderly Subjects: An Example of the PON1 Gene in the Danish 1905 Birth Cohort
... enzyme PON1 is associated with susceptibility to cardio- vascular disorders (W atson et ...Recently, PON1 gene polymorphisms have been found to affect human survival (B onafe et ...the PON1 ...
8
Interaction between polyphenols intake and PON1 gene variants on markers of cardiovascular disease: a nutrigenetic observational study
... In our analysis, high and low antioxidant intakes did not exert any beneficial effect on the target phenotypes if the genetic background related to PON1 gene was not considered. These results are in line ...
10
Correlation Between Serum PON1 Arylesterase Activity and Rs 854573 PON1 A Polymorphism with Type 2 Diabetes in an Eastern Indian Cohort
... of PON1 and risk of diabetes and related disorders. PON1 gene harbors nearly 200 single nucleotide polymorphisms (SNPs) of which -909 G>C (rs854572), -162 A>G (rs705381), -108 C>T (rs705379) ...
12
Paraoxonase 1 Response to a High-Fat Diet: Gender Differences in the Factors Involved
... serum PON1 levels, such as the positive correla- tion found between both parameters would indicate (R = ...decreased PON1 levels cannot be attributed to alterations in the SR-BI me- diated PON1 ...
7
Human Serum Paraoxonase (PON-1) and hemochromatosis gene (HFE) gene polymorphisms in occupationally exposed lead workers from Saudi Arabia
... 2008). Gene polymorphisms at codon 55 (leucine/methionine substitution [T→A], Exon 3, allele 1), and at codon 192 (glutamine /arginine substitution [A→G], Exon 6, allele 2) in the PON1 gene affects ...
9
Click here to download PDF version of the article !
... Interestingly, a host of non-communicable disorders, which have been found to be associated with FGR, have recently been shown to also be associated with PON1 polymorphism. Diabetic nephropathy [16], metabolic ...
5
Key words
... liver. PON1 is believed to contribute to the anti-atherogenic and anti-inflammatory proper- ties of HDL; it degrades lipid peroxides, decreases HDL susceptibility to peroxidation, glycation, and ...
8
Polymorphism of genes associated with increased cardiovascular risk and cognitive function in patients with chronic heart failure and in healthy persons: the pilot study
... of PON1 (L55M А>Т and Q192R A>G) gene with cognitive functions in patients with CAD, is probably mediated not only by impact of this gene on lipid metabolism by the increase of atherogenic ...
5
Relationship between the paraoxonase (PON1) L55M and Q192R polymorphisms and obesity in a Mexican population: a pilot study
... Recently, PON1 has been found in the interstitial space between unilocular cells (white fat cells) of the adipose tissue ...The PON1 gene contains two polymorphisms within its coding region: a ...
8
Paraoxonase Gene Polymorphism and Chlamydia pneumoniae Infection in Ischemic Vascular Disease.
... Q/R192 PON1 variant and its activity in ischemic vascular disease and stroke with ...population. PON1 an aryl esterase associated with HDL is found to be responsible for the antioxidant capacity of ...
204
<p>Frontocingulate Dysfunction Is Associated with Depression and Decreased Serum PON1 in Methamphetamine-Dependent Patients</p>
... 4–6 PON1 and PON3 are mostly located in the plasma and protect the circulating lipids from oxidation, probably due to their ability to hydrolyze oxidized ...Serum PON1 levels are primar- ily determined by ...
11
“Paraoxonase 1 in Type 2 Diabetes Mellitus - A Review” by A. Jamuna Rani, S.V.Mythili, India.
... 1 gene is located in the long arm of chromosome ...human PON1 cDNA clones and protein sequence analysis indicated that the mature protein retain their hydrophobic signal sequences, with only the amino ...
5
Ethnic variations in paraoxonase1 polymorphism in the Malaysian population
... Abstract. The role of high-density lipoprotein associated paraoxonase (PON) 1 in protection against oxidative stress associated with the development of complications in diabetes mellitus has been reported. Variations in ...
6
Associations of the PON1 rs854560 polymorphism with plasma lipid levels: a meta-analysis
... The PON1 gene is located on the long arm of human chromosome 7 (7q21–22), containing 9 exons and 8 ...that PON1 gene rs854560 polymorphism was significantly associated with CHD [7–9], whether ...
10
Effect of cigarette smoking on paraoxonase 1 activity according to PON1 L55M and PON1 Q192R gene polymorphisms
... metabolism. PON1 sig- nificantly decreases lipid peroxidase generation during LDL oxidation in the presence of HDL modification by lipid peroxidase [16, ...impairs PON1 activity and thereby compromises ...
6
PARAOXONASE ACTIVITY AND PON1 (Q/R192) GENE POLYMORPHISM IN ISCHEMIC STROKE PATIENTS
... stroke. PON1 might have a protective role against the development of ischemic stroke as its activity and the serum levels of PON1 are variable between individuals (Davies et ...1999). PON1 exhibits ...
8
Original Article Association between gene polymorphisms on chromosome 7 and the risk of ischemic stroke: a meta-analysis
... and PON1 gene Q192R (rs662) polymorphism in both the overall analysis and Asian under all ...Since PON1 gene L55M (rs854560) poly- morphism was reported to be correlated with atherosclerosis ...
23
Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation
... The gene expression data shown in this study for lipoprotein is ...reductions. PON1 gene expression was up regulated among exercise groups compared to the ...its gene induction levels appears ...
8