Post-mortem human brain
brain-coX: investigating and visualising gene co-expression in seven human brain transcriptomic datasets
... from post-mortem human brain tissue samples (Table ...each brain. To cater for this, brain- coX allows the user to select any combination of these ...on brain samples from ...
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Gene Set Enrichment Analysis (GSEA) of Upregulated Genes in Cocaine Addiction Reveals miRNAs as Potential Therapeutic Agents
... Cocaine addiction is a global health problem that causes substantial damage to the health of addicted individuals around the world. Dopamine synthesizing neurons in the brain play a vital role in the addiction to ...
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A novel approach to quantify different iron forms in ex-vivo human brain tissue
... in post-mortem human brain, based on the combination of Electron Paramagnetic Resonance (EPR) and SQUID ...studied brain tissue of an Alzheimer’s patient and a healthy ...
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Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables
... cultured human microglia can be readily used in functional experiments, but it should be stressed that cultured microglia can no longer be compared to their acutely analyzed ...cultured human microglia to a ...
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Aberrant NF kappaB expression in autism spectrum condition : a mechanism for neuroinflammation
... component. Post- mortem brain samples from patients with ASC display neuroglial activation and inflammatory markers in cerebrospinal fluid, although little is known about the underlying molecular ...
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Natriuretic Peptides in Post-mortem Brain Tissue and Cerebrospinal Fluid of Non-demented Humans and Alzheimer's Disease Patients
... of human and canine cortex (McKenzie, 1992; McKenzie et ...the brain of humans is ...to human by providing a detailed mapping of NP and NPR in the frontal lobe of ...various brain regions (Cao ...
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DNA methylation and histone post-translational modification stability in post-mortem brain tissue
... of human post-mortem brains showed that DNA remained attached to histones for at least 30 h after death [12, ...of brain from deceased adult humans that had been infused with “formalin within ...
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Optimization of ultrastructural preservation of human brain for transmission electron microscopy after long post-mortem intervals
... In human samples, for ethical rea- sons, the PMI can range from a few hours up to 100 h [10, 13, 16, 39], during which the degradation of the tissue continues until ...by post fixation with osmium tetroxide ...
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ZnT3 mRNA levels are reduced in Alzheimer's disease post-mortem brain
... Braak-staged human post mortem (pm) brain tissue from medial temporal gyrus, superior occipital gyrus, superior parietal gyrus, superior frontal gyrus and cerebellum from individuals with AD ...
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Post-mortem analysis of neuroinflammatory changes in human Alzheimer’s disease
... from brain banks, and the most common are fixed paraffin- embedded and frozen ...interest. Brain sections could be used at a range of thickness (4 to 30 μm), depending on the experimental ...the ...
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Histopathological Changes Of Cerebral Vessels Secondary To Drug Abuse
... on human cerebral vessels has not been conducted to date. We present a post-mortem, comparative, pathology study on the brains of drug addicts and healthy ...the post-mortem ...
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Preventive immunization of aged and juvenile non-human primates to beta-amyloid
... the human AN1792 trial found evidence of A β phagocytosis by microglia ...decline post-immunization in aged but not juvenile ...aged brain post-mortem, but did not detect any ...
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Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse
... in brain function is critical not only for the development of therapeutics to prolong cognitive health into old age, but also to gain insight into pathological ageing such as Alzheimer ’ s ...structural ...
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Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer’s disease brains: Implications for in-vivo diagnostics
... To the existing literature we added the comparison of the binding properties of different curcumin forms in human brain tissue, which is needed to translate findings for possible use in in-vivo diagnostic ...
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Investigating alterations in autophagy in Alzheimer’s disease using human brain tissue and skin derived fibroblasts
... on post-mortem PD brains with genetic mutations, have proved an important role of macroautophagy mechanism which contributes to dopaminergic neuronal cell ...
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KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients
... in human iPSC-derived neurons and in motor cortex and cerebellar tissue of RTT patients [11, 15, ...different brain areas, we investigated KCC2 ex- pression in four different cortical areas and hippocam- ...
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Post mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells
... and gave a similar PCR product (Fig. 2, lane 2). Moreover, the primers were specific for B. mandrillaris and did not give any PCR product with HBMEC DNA (Fig. 2a, lane 5). Next we determined the potential of this assay ...
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The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer’s disease
... in post-mortem brain samples from healthy elderly in- dividuals and AD patients of various AD neuropa- thological stages according to Braak [8, ...in brain capillaries of healthy elderly ...
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Mind the Gaps: Ontogeny of Human Brain P-gp and Its Impact on Drug Toxicity
... to post-natal age 3–6 months and compared them to adults (14) (Table ...affin-embedded, post-mortem brain ...at post-natal age 3–6 ...study. Post-mortem interval, method of ...
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Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson’s disease
... of post-mortem PD and control ...on human brain samples including the present one have reported that SNCA-intron1 region in the SN is signifi- cantly hypomethylated ( ≥ 90%) both in control ...
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