posttranslational modification
Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity
... HNE modification target ...via posttranslational modification (PTM) and mutation trigger the formation of aggregated, toxic aSyn species, which interfere with cellular ...
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Impact of the Adenoviral E4 Orf3 Protein on the Activity and Posttranslational Modification of p53
... the modification states of particular resi- dues, that is, the absence or presence of particular PTMs, in the three p53 populations isolated from normal human cells that we have now ...of posttranslational ...
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Posttranslational Modification of HOIP Blocks Toll Like Receptor 4 Mediated Linear Ubiquitin Chain Formation
... ABSTRACT Linear ubiquitination is an atypical posttranslational modification catalyzed by the linear-ubiquitin-chain assembly complex (LUBAC), containing HOIP, HOIL-1L, and Sharpin. LUBAC facilitates NF- ...
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Posttranslational Modification of Vesicular Stomatitis Virus Glycoprotein, but Not JNK Inhibition, Is the Antiviral Mechanism of SP600125
... Vesicular stomatitis virus (VSV), a negative-sense single-stranded-RNA rhabdovirus, is an extremely promising oncolytic agent for cancer treatment. Since oncolytic virotherapy is moving closer to clinical application, ...
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Posttranslational Modification and Cell Type-Specific Degradation of Varicella-Zoster Virus ORF29p
... the posttranslational modification of ORF29p to attempt to unravel the basis for the subcellular targeting of this ...ORF29p modification and degrada- tion occur in 293T, U373MG, and MeWo cells; ...
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The Cyclin-Dependent Kinase Inhibitor Roscovitine Inhibits the Transactivating Activity and Alters the Posttranslational Modification of Herpes Simplex Virus Type 1 ICP0
... and posttranslational modification state of the IE protein, infected cell protein 0 (ICP0), in KOS6  -infected Vero ...ICP0’s posttranslational state by mechanisms other than, or in addition to, ...
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Posttranslational Modification of α-Dystroglycan, the Cellular Receptor for Arenaviruses, by the Glycosyltransferase LARGE Is Critical for Virus Binding
... of posttranslational modification adds another level of com- plexity to the virus-receptor interaction and the virus-host in- ...of modification that is crucial for the biological function of the ...
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Cyclin-Dependent Kinase Activity Is Required for Efficient Expression and Posttranslational Modification of Human Cytomegalovirus Proteins and for Production of Extracellular Particles
... Our laboratory has also used Roscovitine as a tool to inves- tigate the dependence of HCMV infection on cdk activity (38). Drug treatment had a dose-dependent effect on the production of extracellular virus, and the ...
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Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
... N-acetylglucosamine modification and decreases O-linked phosphorylation of the transcription factor Sp1, the effect of hyperglycemia and the hexosamine pathway on eNOS was ...N-acetylglucosamine ...
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EF P Posttranslational Modification Has Variable Impact on Polyproline Translation in Bacillus subtilis
... ABSTRACT Elongation factor P (EF-P) is a ubiquitous translation factor that facilitates translation of polyproline motifs. In order to perform this function, EF-P generally re- quires posttranslational modification ...
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Posttranslational modification and subcellular localization of the p12 capsid protein of herpes simplex virus type 1.
... In contrast, the TrpE-UL35 antiserum reacted with two proteins, designated pl2a and pl2b, which were present in lysates of HSV-infected cells radiolabeled with either [35S]methionine or [r] ...
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The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene.
... 3B show that i in the infected cell lysates of R7306, the phosphoprotein profile was that of the wild-type HSV-1F and ii the phosphoprotein profile of the lysates of cells infected with [r] ...
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Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice
... Addressing this hypothesis, the cur- rent study characterized the multigenerational impacts of DNE on DNMT3A and TET2 expression as well as the expression and phosphorylation of MeCP2 [r] ...
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A small molecule inhibitor of T gondii motility induces the posttranslational modification of myosin light chain 1 and inhibits myosin motor activity
... TgMLC1 modification has not yet been established, it was mapped to the peptide ...TgMLC1 modification is responsible for the motility defect observed in parasites after compound treatment, the activity of ...
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Posttranslational modification at the N terminus of the human adenovirus type 12 E1A 235R tumor antigen.
... To study possible posttranslational processing at the N and C termini and to distinguish between the Adl2 266R and 235R T antigens, we prepared antibodies targeted to synthetic peptides [r] ...
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HIV infection induced posttranslational modification of T cell signaling molecules associated with disease progression
... lymphocytes of HIV-infected individuals. Total amounts of protein tyrosine kinases (PTKs) Lck, Fyn, and ZAP-70 and the zeta chain of the TCR were found significantly decreased in T cells of symptomatic/AIDS patients as ...
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Dynamic Characterization of Protein and Posttranslational Modification Levels in Mycobacterial Cholesterol Catabolism
... ABSTRACT Cholesterol of the host macrophage membrane is vital for mycobacte- rial infection, replication, and persistence. During chronic infection within host lung tissues, cholesterol facilitates the phagocytosis of ...
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The Complexity of the IGF1 Gene Splicing, Posttranslational Modification and Bioactivity
... and posttranslational modifications of human IGF-I. Posttranslational cleavage of pro-IGF-I polypeptides can occur at a unique pentabasic motif and at sites containing the general PC consensus se- quence ...
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Posttranslational modification and intracellular transport of mumps virus glycoproteins.
... Mumps virus apparently differs from Newcastle disease virus in that cleavage of F and formation of HN oligomers are posttranslational modifications which occur after the appearance of th[r] ...
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ORC, MCM, and Histone Hyperacetylation at the Kaposi's Sarcoma-Associated Herpesvirus Latent Replication Origin
... Posttranslational modification of histone tails may distinguish chromosomal boundaries and establish higher-order 12566 Downloaded from http://jvi.asm.org/ on November 8, 2019 by guest T[r] ...
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