potential drug targets
Identification of potential drug targets by subtractive genome analysis of <em>Escherichia coli</em> O157:H7: an in silico approach
... of potential drug ...and drug target prioritization parameters (Figure 1), with the goal of obtaining informa- tion about proteins that were involved in various metabolic pathways of ...any ...
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Identification of polycystic ovary syndrome potential drug targets based on pathobiological similarity in the protein-protein interaction network
... Some drugs are targeting several PCOS potential drug targets such as Alitretinoin targeting RXRA, RARA, RXRB and RARG; Tamoxifen targeting ESR1 and ESR2. Retinoid X receptors (RXRs) and retinoic acid ...
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Discovery and validation of potential drug targets based on the phylogenetic evolution of GPCRs
... important drug targets for the pharmaceutical ...out potential drug targets on the basis of amino acid se- quences and seven transmembrane regions (TMs) of ...
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Microarray Informatics Approach Used In Identification of Potential Drug Targets for Prostate Cancer
... or drug response[6]. We successfully identify potential drug targets which are strongly related to the well known drugs for prostate cancer treatment and also discover more potential ...
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Aminoacyl tRNA synthetases as potential drug targets of the Panthera pathogen Babesia
... We observed no distinct domains amongst the aaRSs from B. bovis, B. microti and B. bigemina (Figs. 3, 4, 5). In Babesia spp., RRS and SRS were found to have an addi- tional NTD, while their PRSs have an additional CTD, ...
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Maximum flow approach to prioritize potential drug targets of Mycobacterium tuberculosis H37Rv from protein-protein interaction network
... identify drug targets for the most studied strain of TB, Myco- bacterium tuberculosis ...Structure-based drug target identification is one of these approaches [11, ...for drug targets ...
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Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer
... Abstract: Increased aldehyde dehydrogenase 1 (ALDH1) activity has been found in the stem cell populations of leukemia and some solid tumors including non-small-cell lung cancer (NSCLC). However, which ALDH1’s isoenzymes ...
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Choke Point Analysis with Subtractive Proteomic Approach for Insilico Identification of Potential Drug Targets in Shigella Dysenteriae
... those targets which are non- homologous to human gut ...of drug targets non-homologous to human gut flora so that the drug administered against the targets do not bind unintentionally ...
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20. Revealing potential drug targets against Proto-oncogene Wnt10B by comparative molecular docking
... Wingless type mouse mammary tumor virus (MMTV) integration site-10B (Wnt10B) is an important member of the Wnt protein family that functions as cellular messenger in paracrine manner. Aberrant Wnt10B activity is the ...
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Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18
... and drug molecules has pointed out the best compound with the lowest binding energy that can be taken into account for the novel drug ...toxicity, drug score, and Lipinski’s rule of five, it is sug- ...
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Insilico Molecular Characterization of Potential Drug Targets in Oral Cancer
... Abstract: Oral cancer is the most frequent type of cancer occurring in India. It has ranked in top three types of cancer in the country. Most oral cancers occur as squamous cell carcinomas (SCCs) and many OSCCs develop ...
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In silico analyses of heparin binding proteins expression in human periodontal tissues
... as potential drug ...designing drug targets, the fact that these pathways are important in several other physiological processes and therefore their inhibition can also result in undesirable ...
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Conserved Fungal Genes as Potential Targets for Broad-Spectrum Antifungal Drug Discovery
... encode potential new targets for ...as potential drug targets from key fungal ...broad-spectrum potential, drug target potential, fungal specificity, availability ...
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Geometric characterisation of disease modules
... identify potential drug ...FDA-approved drug targets (see ...considered potential drug targets by the Human Protein Atlas (Thul et ...
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DanQi Pill protects against heart failure through the arachidonic acid metabolism pathway by attenuating different cyclooxygenases and leukotrienes B4
... the potential drug targets of these ...infer drug-targets in the genome-wide scale ...known drug (drug space)-tar- get (target space) interactions, for a query drug ...
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Choosing anticancer drug targets in the postgenomic era
... of potential drug targets that are geneti- cally validated in the sense that they are recurrently altered in tumors and play a causal role in maintenance of the malignant ...these potential ...
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Leukotriene receptors as potential therapeutic targets
... This drug is effective in allergic rhinitis and several types of asthma, ...this drug is effective for chronic bron- chial asthma in pediatric and adult ...this drug significantly inhibits pollinosis ...
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Tumour macrophages as potential targets of bisphosphonates
... Using a murine model of mammary carcinoma, Coscia et al investigated the cellular effects of decreased VEGF levels caused by clinically achievable doses of ZOL [83]. As discussed above, VEGF is one of the foremost ...
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Caveolae and Caveolin: Potential Targets for Cardioprotection
... Caveolae and caveolins are comparatively new players in a relatively saturated field of cardiovascular diseases and are undoubtedly regulating various aspects of cardiovascular system. Clearly loss of caveolin-1 has ...
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Potential therapeutic targets of Guggulsterone in cancer
... has been benefecial only to the patients with advanced colorectal cancerregarding their survival and quality of life [49]. The other problems that happen to be with the conventional chemotherapy are systemic side effects ...
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