Potential targets.
POTENTIAL TARGETS AGAINST LEPROSY – A PHARMACOLOGICAL REVIEW
... Leprosy is caused by a bacteria called Mycobacterium leprae or Hansen's bacillus. Leprosy is named after a Norwegian physician Gerhard H. Armauer Hansen. It is unclear how leprosy goes from body to body, some think it is ...
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Castration-resistant prostate cancer: potential targets and therapies
... CaP is a heterogeneous disease with a number of different genetic/pathophysiologic clusters. Future directions to treat CRPC patients will include custom tailoring of therapies designed on the basis of specific molecules ...
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An ongoing search for potential targets and therapies for lethal sepsis
... Sepsis, which refers to a systemic inflammatory response syndrome resulting from a microbial infection, represents the leading cause of death in intensive care units. The pathogenesis of sepsis remains poorly understood ...
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Fungal Extracellular Vesicles as Potential Targets for Immune Interventions
... The urgent need to develop new strategies to prevent and combat fungal infections is efficiently illustrated by the global number of deaths (1.5 million annually) caused by invasive mycoses. There are no licensed ...
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NMDA receptors are important regulators of pancreatic cancer and are potential targets for treatment
... The viability of pancreatic cancer PanC-1, BXCPC3, and HPAC-1 cells was clearly reduced by the GluN1 antagonist and channel-blocker, dizocilpine maleate (MK-801), in a concentration dependent fashion, and by an antibody ...
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Potential targets of TMEM176A in the growth of glioblastoma cells
... Human transmembrane protein 176A (TMEM176A) was mapped to human chromo- some 7q36.1, which belongs to the TMEM family. Although the functions of TMEM176A are not well known in the context of cancers, growing reports ...
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Lipid metabolism reprogramming and its potential targets in cancer
... is strongly up-regulated in human cancers to satisfy the demands of increased membrane biogenesis [7, 8, 21, 23]. Lipid uptake and storage are also elevated in malignant tumors [24–33]. Sterol regulatory element-binding ...
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INSILICO SCREENING OF NNRTI AS POTENTIAL TARGETS FOR TUMOR CONTROL
... Based on the hypothesis that nevirapine inhibits reverse transcriptase activity of telomerase, RT domain of hTERT was considered as the docking target.. Due to the deficit of crystallog[r] ...
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Tumor-associated macrophages, potential targets for cancer treatment
... The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated ...
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FAK and paxillin, two potential targets in pancreatic cancer
... pancreas, play a vital role in tumorigenesis. During development of pancreatic cancer or during inflammation, PSCs undergo morphological and functional changes to become myofibroblast -like cells. They express α-smooth ...
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Solute carrier transporters: potential targets for digestive system neoplasms
... and their dysregulation may be associated with increased carcinogenesis, tumor progression, and metastasis, as well as with resistance of cancer cells to chemotherapeutic agents. The role of SLC family proteins in ...
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The sweet trap in tumors: aerobic glycolysis and potential targets for therapy
... Although the mechanism triggering the Warburg effect in tumors is not well clear, the oncogenic stress including activation of oncogenes and inactivation of tumor suppressors plays a critical role. Aerobic glycolysis ...
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Tumour macrophages as potential targets of bisphosphonates
... Using a murine model of mammary carcinoma, Coscia et al investigated the cellular effects of decreased VEGF levels caused by clinically achievable doses of ZOL [83]. As discussed above, VEGF is one of the foremost ...
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Caveolae and Caveolin: Potential Targets for Cardioprotection
... The potential role of caveolin in cardiovascular physiology has become apparent by the discovery of cavelin-1 and caveolin-3 KO mice and double knockout mice, which have cardiomyopathic ...
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RAGE and Soluble RAGE: Potential Therapeutic Targets for Cardiovascular Diseases
... may be simultaneously up-regulated by AGEs and act as a negative feedback loop to compensate for the damaging ef- fects of AGEs. We and others have found positive correlations between plasma sRAGE or esRAGE and AGEs ...
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Application of local singularity in prospecting potential oil/gas Targets
... secondary carbonate (1C), from 9637 soil samples amassed within a large area of 11.2 × 10 4 km 2 in the Songpan-Aba district, Sichuan Province, southwestern China, were ana- lyzed. By eliminating the interference of ...
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Chromophobe renal cell cancer - review of the literature and potential methods of treating metastatic disease
... a potential target for kinase inhibitors like: imat- inib, dasatinib, ...The potential targets for other kinase inhibitors (sunitinib and sorafenib) in ChRCC seem to be VEGFR and ...
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DanQi Pill protects against heart failure through the arachidonic acid metabolism pathway by attenuating different cyclooxygenases and leukotrienes B4
... Results: A novel therapeutic effect pattern of DQP was identified. After determining the compounds in DQP, we used DrugCIPHER-CS to predict their potential targets. These potential targets ...
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Insilico Molecular Characterization of Potential Drug Targets in Oral Cancer
... drug targets with their basic physicochemical properties which states that MYC protein has low hydrophobicity, more alpha helix and single domain with two ...drug targets and pave a new dimension to combat ...
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Genes and primary headaches: discovering new potential therapeutic targets
... TRP channels have been among the most aggressively pursued drug targets over the past few years and several studies suggested these channels as potential therapeutic targets in migraine. Both ...
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