PRDM16/Prdm16
PRDM16 functions as a suppressor of lung adenocarcinoma metastasis
... MUC4 has been reported to promote cancer progres- sion involving EMT in a variety of epithelial carcinomas [18–22]. However, the role of MUC4 in the occurrence and development of lung cancer seems controversial. Prabin ...
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PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature
... of PRDM16 has no biological ...both PRDM16 isoforms are overexpressed to varying degrees (27), and high expression of PRDM16 in AML is associated with worse overall survival (28–31), suggesting that ...
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Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex
... of Prdm16 in the regulation of multipolar cells, we analyzed NeuroD1 promoter activity and expression ...of Prdm16 expression in NeuroD1-positive multipolar cells in ...that Prdm16 gain of function ...
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Original Article Methylation of PRDM2, PRDM5 and PRDM16 genes in lung cancer cells
... [11]. PRDM16 gene is located on human chromo- some 1, encoding a protein of 1275 amino ...acids. PRDM16 gene is known to be rearranged in acute myeloid leukaemia (AML) and myelo- dysplastic syndrome (MDS) ...
7
Original Article PRDM16 inhibits atherosclerosis plaque forming through enhancing the function of periaortic brown adipose tissue
... in PRDM16-pAdenoG group was mark- edly lower than the other groups, while the value of BG was ...lated PRDM16 play an important role on the happen of ...of PRDM16 on atherosclerosis, HE staining on ...
11
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
... that Prdm16 acts as a determining factor in subcutaneous adipocytes to establish a gene program under basal conditions that can allow for activation of thermogenesis in response to cold or ...increase ...
11
Controlling Thermogenesis: Understanding the Role of PRDM16 in the Development and Function of Brown Fat
... against Prdm16 results in an increase in the expression of muscle enriched ...for PRDM16 are embryonic lethal, but have an increase in the expression of certain skeletal muscle genes in their ...of ...
120
Flavonoids as inducers of white adipose tissue browning and thermogenesis: signalling pathways and molecular triggers
... Quercetin is extracted from onion peel and has been demonstrated to have many biological functions, such as antioxidant, anti-inflammatory and anti-obesity effects [70]. Many studies have demonstrated that quercetin ...
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Recent progress in the study of brown adipose tissue
... of adipogenesis. However, different opinion was rendered in 2007 when PR domain containing 16 (PRDM16) was discovered to be a master regulator of brown adipocyte differentiation [6]. Investigation of its specific ...
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Novel discovery of Averrhoa bilimbi ethanolic leaf extract in the stimulation of brown fat differentiation program in combating diet induced obesity
... DBB was identified to contain rich source of flavonoid compounds in LCMS analysis including apigenin deriva- tives, kaempferol 3,4′-dixyloside, apigenin 7-cellobioside, syringaresinol O-beta-D-glucoside, vitexin ...
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The methylation profiles of PRDM promoters in non–small cell lung cancer
... PRDM5, PRDM16 mRNA, and protein expression levels of distant lung tissues were lower than in cancer tissues and adjacent ...and PRDM16 expression may be suppressed due to gene hypermethylation in lung ...
12
Synergism between cAMP and PPARγ signalling in the initiation of UCP1 gene expression in HIB1B brown adipocytes
... (PGC1𝛼, PRDM16, PPAR𝛾 C/EBP𝛽) to PKA or PPAR𝛾 activation/inhibition were different from UCP1, and, combined with reporter studies, we provide evidence that these responses to PKA activation and the PPAR𝛾 agonist ...
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Genome-wide brain DNA methylation analysis suggests epigenetic reprogramming in Parkinson disease
... We therefore performed a gene-based analysis that revealed genes that contained DMRs in both the DMV ( FRMD4A and GPT ) and the CG ( HOXA3 and PRDM16 ) of patients with PD in which the l[r] ...
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Type 2 diabetes is associated with decreased PGC1α expression in epicardial adipose tissue of patients with coronary artery disease
... Adipose tissue samples were minced in TriZol reagent (Invitrogen) and homogenized completely on ice. Total RNA was extracted by chloroform and purified through RNeasy minicolumns. After on-column DNase treat- ment, RNA ...
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