precision oncology
Polypharmacology in Precision Oncology: Current Applications and Future Prospects.
... There are many challenges and considerations that need to be taken into account when repurposing a drug on the basis of a new drug-protein interaction. When the drug was designed through tar- get-based drug discovery it ...
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Community-driven development of a modified progression-free survival ratio for precision oncology
... recent precision oncology trials, MOSCATO 01 and WINTHER, revealed significantly improved concordance with physician- perceived clinical benefit and identified comparable proportions of patients who ...
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Circulating tumor cells in precision oncology: clinical applications in liquid biopsy and 3D organoid model
... Circulating tumor cells (CTCs) are a rare subset of cells found in the blood of patients with solid tumors, which func‑ tion as a seed for metastases. Cancer cells metastasize through the bloodstream either as single ...
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<p>Precision oncology: lessons learned and challenges for the future</p>
... a precision oncology program starts with ef fi cient patient ...for precision medicine, but is only feasible within organized health systems (Figure 2), eg, the GREAT KIDS program at The University of ...
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Precision oncology: separating the wheat from the chaff
... different studies displayed in table 1, after median turn- around time of 3 weeks, on average 40% of the patients had at least one potentially targetable genomic alteration in tumour NGS. However, access to a matched ...
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Streamlining Detection of Fusion Genes in Colorectal Cancer: Having "Faith" in Precision Oncology in the (Tissue) "Agnostic" Era.
... Overall, kinase gene fusions were identified in 0.9% of the 2314 CRC cases, confirming the low frequency of these genomic aberrations in an unselected CRC population. However, when multi-omics data were combined and gene ...
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CVE: an R package for interactive variant prioritisation in precision oncology
... A number of web applications have been developed to facilitate interactive prioritisation of variants (Additional file 1: Table S1). BrowseVCF is a comprehensive open source web application based on Python [16], enabling ...
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Precision oncology in urothelial cancer
... Although the successful practice of genomics- driven medicine is not without its challenges, we are poised to deliver more rational management options to many through the broader practice of precision ...
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Mutational Landscapes of Smoking-Related Cancers in Caucasians and African Americans: Precision Oncology Perspectives at Wake Forest Baptist Comprehensive Cancer Center
... in precision oncology initiatives due to the enrollment criteria and cost associated with the clinical sequencing ...major precision oncology programs in the country to determine whether ...
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Variant information systems for precision oncology
... Variant Information Systems (VIS) are becoming a fun- damental necessity for scaling clinical availability of com- prehensive variant information in precision oncology. However, the informed selection of ...
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Importance of genetic screens in precision oncology
... term precision oncology was mainly used to describe the use of targeted therapies such as epidermal growth factor receptor (EGFR) inhibitors or BCR/ABL1 inhibitors like gefitinib/erlotinib and ...2013, ...
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Beyond Computational Genomics towards Systems Metabolomics for Precision Oncology
... Coordinated sets of extremely numerous digital data, on a given social or economic event, are treated by Artificial Intelligence tools to obtain reasonably accurate, valuable predictions. The same approach, applied to ...
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Identifying Key Sentences for Precision Oncology Using Semi Supervised Learning
... a larger ratio of positive predictions for U . The lin- ear classifiers SVM and Logistic Regression per- form much better than NB, the latter modelling an inaccurate probability distribution. In both strict and tolerant ...
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From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards
... In oncology, PM is being implemented through tumor boards (TB), multidisciplinary meetings where patients are discussed from all possible perspectives (diagnostic radiology, surgery, pathology, genetics, on- ...
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Future paradigms for precision oncology
... of precision medicine to practice, sufficient evidence about precision medicine being as good or better than present therapies is requisite for the larger scientific and medical community to use the ...in ...
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Evidence Based Medicine, in Precision Oncology
... surviv- al in patients with metastatic breast cancer, as well as disease-free and overall survival in patients with localized invasive breast cancer. That said, Her 2 posi- tive breast cancer response to Herceptin, (if ...
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An appraisal of drug development timelines in the Era of precision oncology
... in oncology after the introduction of biomarker-based therapies, we reviewed agents newly approved for the treatment of advanced cancer by the FDA between September 25th 1998 (FDA approval of trastuzumab for ...
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Advancing Population Health: New Models and the Role of Research. An Overview of the 22nd Annual Health Care Systems Research Network Conference
... Abstract The Health Care Systems Research Network (formerly HMO Research Network) held its annual conference in Atlanta, Georgia, in April 2016. The conference, with a theme of “Advancing Population Health: New Models ...
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<p>Impact of Next-Generation Sequencing on Outcomes in Hepatocellular Carcinoma: How Precise Are We Really?</p>
... for Precision Oncology (DEPO) demonstrated that of the 354 patients in the Liver Hepatocellular Carcinoma (LIHC) cohort, only 6% of patients had at least one currently druggable mutation compared to a rate ...
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JAMA Oncology
... amount of prognostic information for late distant recurrence (5-10 years)... Gene expression based signatures should.[r] ...
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