primary human hepatocytes
Serum-Derived Hepatitis C Virus Infection of Primary Human Hepatocytes Is Tetraspanin CD81 Dependent
... of primary human hepatocytes ...or human (H) CD81-LEL fusion proteins and, 3 days postplating, hepatocytes FT257 (30-year-old female with hydatid cyst) or FT259 were inoculated with ...
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Assembly of Hepatitis B Virus Envelope Proteins onto a Lentivirus Pseudotype That Infects Primary Human Hepatocytes
... a human immunodeficiency virus (HIV) packaging construct, (ii) a transfer plasmid expressing a reporter gene, and (iii) a plasmid expressing large (L), middle (M), and small (S) HBV envelope ...cultured ...
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Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes
... ABSTRACT The structural maintenance of chromosomes 5/6 complex (Smc5/6) is a host restriction factor that suppresses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing the X protein (HBx), ...
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Murine Retroviral Pseudotype Virus Containing Hepatitis B Virus Large and Small Surface Antigens Confers Specific Tropism for Primary Human Hepatocytes: a Potential Liver-Specific Targeting System
... of primary hepatocytes by MLV(HBV) pseudotype virus is the low rate of cell ...Most primary human hepatocytes are probably in the quiescent stage; the use of hepatocyte growth factor ...
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Hepatitis C Virus Induces Epithelial-Mesenchymal Transition in Primary Human Hepatocytes
... HCV-infected primary human ...using human hepatoma cell lines ...of primary human hepatocytes induces EMT by the activation of -catenin without involving the Wnt signaling ...
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Genomic responses to hepatitis B virus (HBV) infection in primary human hepatocytes
... Cultured primary human hepatocytes (PHH) are the closest in vitro model to human liver and constitute a very predictive model for pharmaco-toxicology in vivo ...
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Detection of nanolevel drug metabolites in an organotypic culture of primary human hepatocytes and porcine hepatocytes with special reference to a two-compartment model
... on human plasma and urine obtained from clinical trials and super- natant during early in vitro ...inside human hepatocytes, where the drug is extensively ...of primary human ...
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<p>Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system</p>
... containing primary human hepatocytes was used to investi- gate the effects of continuous remimazolam application over 5 days, thereby mimicking the situation of a patient receiving a continuous ...
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Primary Human Hepatocytes Are Susceptible to Infection by Hepatitis Delta Virus Assembled with Envelope Proteins of Woodchuck Hepatitis Virus
... Hepatitis B virus (HBV) and hepatitis delta virus (HDV) share the HBV envelope proteins. When wood- chucks chronically infected with woodchuck hepatitis virus (WHV) are superinfected with HDV, they produce HDV with a WHV ...
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Assembly of Hepatitis Delta Virus: Particle Characterization, Including the Ability To Infect Primary Human Hepatocytes
... Efficient assembly of hepatitis delta virus (HDV) was achieved by cotransfection of Huh7 cells with two plasmids: one to provide expression of the large, middle, and small envelope proteins of hepatitis B virus (HBV), ...
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Alpha Interferon Inhibits Hepatitis C Virus Replication in Primary Human Hepatocytes Infected In Vitro
... in primary cultures of healthy human hepa- tocytes infected in ...prepared primary cultures of healthy human hepatocytes from 15 HCV-seronegative donors (Table ...healthy human ...
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The metabolomics of acetaminophen toxicity observed in human biofluids and cultured primary human hepatocytes
... plating. Hepatocytes were exposed to DMEM containing insulin and 13 C glucose substituted for regular glucose for 2 hours at 2, 24, and 48 hours after ...the hepatocytes, the 24 hour time point may be a ...
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Efficient adenoviral mediated ornithine transcarbamylase expression in deficient mouse and human hepatocytes
... of primary human hepatocytes infected with an adenoviral vector carrying beta- galactosidase expressed the exogenous ...mouse hepatocytes in ...(OTC)-deficient primary ...
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Entry of Hepatitis B Virus into Immortalized Human Primary Hepatocytes by Clathrin-Dependent Endocytosis
... Gradual loss of susceptibility to HBV infection in HuS-E/2 cells. Although they are transduced with hTERT and HPV/E6E7, HuS-E/2 cells still maintain the characteristics of primary hepato- cytes after 30 weeks in ...
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In Vitro Alterations Do Not Reflect a Requirement for Host Cell Cycle Progression during Plasmodium Liver Stage Infection
... that hepatocytes from the natural host could respond differently to Plasmodium infection than those of the laboratory ...most human malaria mortality, we turned to an ex vivo model of ...of primary ...
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Establishment of B-Cell Lymphoma Cell Lines Persistently Infected with Hepatitis C Virus In Vivo and In Vitro: the Apoptotic Effects of Virus Infection
... infect primary human ...of hepatocytes (data not ...several primary human hepatocyte cultures derived from different sources, though the length of the culture period ...infect ...
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Insulin Decreases Inflammatory Signal Transcription Factor Expression in Primary Human Liver Cells after LPS Challenge
... using primary human hepatocytes (PHHs) and to study the effects of insulin on the hepatic inflammatory signaling cas- ...culture. Primary he- patocyte cultures were challenged with various ...
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Efficient Infection of Primary Tupaia Hepatocytes with Purified Human and Woolly Monkey Hepatitis B Virus
... and primary human hepatocytes are not easily available for in vitro infection ...of primary human hepatocytes is highly variable ...
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Original Article Increased expression of Zinc finger protein 267 in non-alcoholic fatty liver disease
... of primary human hepatocytes with palmitic acid induced a dose-dependent upregulation of ZNF267 ex- ...in human cirrhotic liver tissue and might promote liver fibrosis through alteration of ...
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Thesis
... cells, primary human hepatocytes, and VL-17A ...the primary human hepatocytes and HepG2 cells were used to study AKR1B10 and SORD mRNA induction in ...hepatocytes. ...
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