primitive endoderm
Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst
... extraembryonic trophectoderm (TE) and the primitive endoderm (PrE). Whereas the mechanisms of TE specification have been extensively studied, segregation of PrE and the pluripotent epiblast (EPI) has ...
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Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4
... The inner cell mass of the mouse blastocyst gives rise to the pluripotent epiblast (EPI), which forms the embryo proper, and the primitive endoderm (PrE), which forms extra-embryonic yolk sac tissues. All ...
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FGF4 is required for lineage restriction and salt and pepper distribution of primitive endoderm factors but not their initial expression in the mouse
... and primitive endoderm (PrE) lineages within the inner cell mass (ICM) of the mouse blastocyst involves initial co-expression of lineage-associated markers followed by mutual exclusion and salt-and-pepper ...
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Differential plasticity of epiblast and primitive endoderm precursors within the ICM of the early mouse embryo
... Our data suggest that the potency of epiblast and PrE precursors at various embryonic stages is broader than their undisturbed fate. Moreover, restriction in potency does not correlate directly with mutually exclusive ...
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LIF supports primitive endoderm expansion during pre implantation development
... We have previously shown that LIF promotes a population of ESCs primed towards an extraembryonic fate (Morgani et al., 2013), marked by the expression of a highly sensitive fluorescent reporter for the endoderm ...
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FGF signal dependent segregation of primitive endoderm and epiblast in the mouse blastocyst
... Treatment with specific FGF/MAP kinase signal inhibitors after the morula stage phenocopies the Grb2 mutant Previously our analysis of Grb2 mutants showed that all ICM cells take up the [r] ...
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Regulation of extra embryonic endoderm stem cell differentiation by Nodal and Cripto signaling
... parietal endoderm as well as to trophoblast in chimeric rat embryos in the absence of prior Nodal treatment (Galat et ...similar primitive endoderm-like lines derived from embryonal carcinoma cells ...
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Inhibition of LSD1 promotes the differentiation of human induced pluripotent stem cells into insulin-producing cells
... the endoderm differentiation efficiency (SOX17 + CXCR4 + is the surface marker on defining endoderm cells) increased by approximately 10% ...definitive endoderm during embryonic develop- ment [22, ...
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The endoderm from a diverse perspective
... all endoderm types, from the emergence of the extra-embryonic primitive endoderm in the pre- implantation blastocyst to the beginning of regionalization in the gut tube at the 13-somite ...visceral ...
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Conversion from mouse embryonic to extra embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states
... We next asked whether gene expression of cXEN cells is globally similar to embryo-derived XEN cells using cDNA microarray analysis (Fig. 2B). We performed hierarchical cluster analysis of absolute gene expression values ...
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Lineage specification in the mouse preimplantation embryo
... ABSTRACT During mouse preimplantation embryo development, totipotent blastomeres generate the first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm.. In[r] ...
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Regulative deployment of the skeletogenic gene regulatory network during sea urchin development
... therefore, the actual fraction of NSM cells that were present at the time of PMC removal and which activated the skeletogenic GRN without dividing was presumably greater than 66%. Because NSM cells and PMCs are both ...
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The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish
... Specific regions of the vertebrate extra-embryonic tissues have been shown to function as important signaling centers for early body patterning. In mammals, for example, the extra-embryonic anterior visceral ...
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Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation
... the endoderm of mid-gastrula-stage embryos to different segments of the embryonic gut of early-somite-stage embryos was ...entire endoderm population of the MS embryo to achieve a comprehensive fate map of ...
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Regulation of lung endoderm progenitor cell behavior by miR302/367
... foregut endoderm down the organ-specific pathways is only partially ...lung endoderm differentiation through regulation of Wnt signaling (Zhang et ...lung endoderm progenitor cell polarity through ...
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S1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence
... gastrulation, endoderm migration is controlled by chemokine signaling (mediated by Cxcl12b and its receptor Cxcr4a), and this is not required for the migration of mesodermal cells (Mizoguchi et ...anterior ...
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Origin and evolution of endoderm and mesoderm
... Bilateria, endoderm and mesoderm involute together and have to be separated after ...and endoderm in the developing ...of endoderm induction to the function of the protein (Marcellini et ...groups ...
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483.full.pdf
... elegans endoderm pathway evolve as it did and not remain with only ELT-2 as the transcriptional activator of the genes performing specification, differentiation, growth and intestinal maintenance? Three reasons ...
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The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation
... visceral endodermal cells at the distal tip of the embryo (Ang and Rossant, 1994), which may be due to a disturbance in normal cell movements that move distal visceral endoderm at 5.5 dpc to an anterior-proximal ...
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Signals governing extraembryonic endoderm formation in the mouse: involvement of the type 1 parathyroid hormone related peptide (PTHrP) receptor, p21Ras and cell adhesion molecules
... Plating of F9 embryoid bodies or isolated ICMs on a fibronectin- coated substrate is sufficient to induce outgrowth and differentia- tion of PE (Grabel and Watts, 1987; Behrendtsen et al., 1995). Furthermore, gradients ...
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