proapoptotic protein
Original Article MicroRNA-10a inhibits A30P α-synuclein aggregation and toxicity by targeting proapoptotic protein BCL2L11
... of proapoptotic protein Bcl-2-associated X protein and cleaved caspase-3 expression and downregulation of antiapoptotic protein B-cell lymphoma-2 (BCL2) ...
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Apoptosis in Coxsackievirus B3-Caused Diseases: Interaction between the Capsid Protein VP2 and the Proapoptotic Protein Siva
... capsid protein VP2 and the proapoptotic protein Siva, which is involved in the CD27/CD70-transduced apoptotic pathway ...a protein which is also expressed in T and B cells, can provide ...
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The Vaccinia Virus F1L Protein Interacts with the Proapoptotic Protein Bak and Inhibits Bak Activation
... F1L protein specifically interacts with ...the proapoptotic protein Bak consistently coeluted with the Flag-tagged version of F1L, while no inter- actions with Bax, Bcl-2, Bcl-xL, or Mcl-1 were ...
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Enterovirus 71 2B Induces Cell Apoptosis by Directly Inducing the Conformational Activation of the Proapoptotic Protein Bax
... 2B protein that are crucial for mitochondrial localization and Bax ...2B protein and truncation proteins containing an N-terminal GFP fusion [pGFP-2B(1– 80) and pGFP-2B(1– 63)] were constructed and ...
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Fowlpox Virus Encodes a Bcl-2 Homologue That Protects Cells from Apoptotic Death through Interaction with the Proapoptotic Protein Bak
... two proapoptotic proteins absolutely required for the induction of apoptosis, represent a crucial lynchpin in the regulation of cell death (51, 82, 89), and vBcl-2 proteins inhibit apoptosis by interfering with ...
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The Herpes Simplex Virus 1 US3 Protein Kinase Blocks Caspase-Dependent Double Cleavage and Activation of the Proapoptotic Protein BAD
... BAD fused to GST (lanes 13 and 14). These results are of interest from two points of view. First, whereas the residues encoding the BH3 site absent from the gstBAD1-140 were, as expected, to be essential for the ...
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Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis
... LAM has been described as a destructive, low-grade metastasizing neoplasm (10). Cells carrying TSC2 mutations have been identified in body fluids including blood, chylous effusions, and urine from women with LAM (11). ...
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Original Article Protective effect of TSG against oxygen-glucose deprivation in cardiomyoblast cell line H9c2: involvement of Bcl-2 family, Caspase 3/9, and Akt signaling pathway
... In conclusion, our results clearly demonstrated that OGD-induced in vitro ischemic cell model apoptosis included decrease in cell viability, loss of ΔΨ m , upregulation of Caspase-3, Cas- pase-9, and proapoptotic ...
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Reovirus Infection or Ectopic Expression of Outer Capsid Protein μ1 Induces Apoptosis Independently of the Cellular Proapoptotic Proteins Bax and Bak
... few proapoptotic agents can induce apoptosis in Bax ⫺/⫺ Bak ⫺/⫺ DKO ...a proapoptotic protein by allowing its BH-3 helix to insert into the outer mitochondrial membrane ...
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Hepatitis C Virus Infection Induces Apoptosis through a Bax-Triggered, Mitochondrion-Mediated, Caspase 3-Dependent Pathway
... infected patients, the Fas-mediated signal pathway is involved in apoptosis of virus-infected hepatocytes (24). It was also reported that HCV (JFH1 strain) infection induced apoptosis through a TRAIL-mediated pathway in ...
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Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis
... The inhibition of apoptosis of infected host cells is a well-known but poorly understood function of patho- genic mycobacteria. We show that inactivation of the secA2 gene in Mycobacterium tuberculosis, which encodes a ...
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To kill a tumor cell: the potential of proapoptotic receptor agonists
... intervention. There is currently heightened interest in the extrinsic apoptosis pathway, with several proapoptotic receptor agonists (PARAs) in development. The PARAs include the ligand recombinant human ...
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Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation
... of protein kinase C δ (Figure ...the proapoptotic kinase PKCδ could be activated by caspase-8 and caspase-3 dependent proteolytic cleavage during TNF toxicity in dopaminergic neuronal ...
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Prediction of Proapoptotic Anticancer Therapeutic Response Based on Visualization of Death Ligand-Receptor Interaction and Specific Marker of Cellular Proliferation
... predict proapoptotic anticancer therapy response before or at the very early stage of ...of proapoptotic TRAIL receptors can predict the proapoptotic targeted therapeutic response following TRAIL- ...
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The Role of Phosphorylation in Allosteric Modulation of Caspase-3.
... this protein to quench the DISC of all death receptors which promotes survival by preventing caspase-8 and -10 from proximity induced dimerization at the DISC (Krueger et ...
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Baculoviruses Modulate a Proapoptotic DNA Damage Response To Promote Virus Multiplication
... the proapoptotic pathway and its role in antivirus defense, we investigated the link between the host’s DNA damage response (DDR) and ...inhibitor-of-apoptosis protein, an event that initiates apoptosis in ...
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Vol 70, No 4 (2018)
... Medications based on plants, including Poly- gonum extracts, and conventional cytostatic drugs can influence the metabolism of toxic substances by modulating both nonspecific and specific detoxifying enzymes and by ...
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Short Term International Study For Teachers As A Form of Experiential Learning: A Case Study of American Educators in Turkey
... A hexane fraction of American ginseng suppresses mouse colitis and associated colon cancer: Anti-inflammatory and proapoptotic mechanisms. Cancer Prev Res[r] ...
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Ryu, Mi (2012): Role of TNF-α on progressive glomerulosclerosis in Alport nephropathy. Dissertation, LMU München: Medizinische Fakultät
... The pathomechanisms of the progression of chronic kidney diseases involve progressive glomerulosclerosis with renal parenchymal cell loss by proapoptotic factors. Tumor necrosis factor-alpha (TNF-α) is a ...
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Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis
... and protein expression of BCL-2 in a dose- dependent manner in IPF lung myofibroblasts at 24 hours, mRNA and protein levels of Bcl-xL and Mlc-1, 2 additional members of the BCL-2 family, were not influenced ...
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