proline-rich domain
Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain
... suggest that BIN1 interacts with Tau and is involved in Tau pathology. We therefore decided to characterize the BIN1-Tau interaction and the latter’s putative regulatory mechanisms in more detail. In the present work, we ...
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Promoter-specific transactivation of hepatitis B virus transcription by a glutamine- and proline-rich domain of hepatocyte nuclear factor 1.
... Influence of the orientation and sequence of the HNF1 binding site on transcriptional activity from large surface antigen minimal promoter constructs containing single synthetic HNF1 bin[r] ...
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Disruption of fyn SH3 domain interaction with a proline rich motif in liver kinase B1 results in activation of AMP activated protein kinase
... SH3 domain binds to the proline-rich domain of LKB1 and induces LKB1 cytosol localization in vivo (A) Lysates from HeLa cells expressing Flag-LKB1-WT were immobilized onto Flag-conjugated ...
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The 11-Kilodalton Nonstructural Protein of Human Parvovirus B19 Facilitates Viral DNA Replication by Interacting with Grb2 through Its Proline-Rich Motifs
... SH3 domain of the Grb2 binds to the Ras-guanine exchange factor SOS, which transduces the signal through the Grb2-SOS-Ras-Raf1-MEK-ERK pathway ...One proline-rich motif is sufficient for 11-kDa to ...
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PIKE GTPase Signaling and Function
... PIKE-A differs from PIKE-L and -S by lacking the N-terminal proline-rich domain (PRD), which binds PI 3-kinase. The comparison of the three protein structures is depicted in Figure 1. Interestingly, ...
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Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene
... a proline-rich region and a tyrosine that are highly con- served among the b and g subunit ...The proline-rich domains present in the carboxyl ter- mini of ENaC subunits share a SH3 binding ...
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C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6
... and proline-rich domains of c-Cbl are required for interactions with TRAF6 The major pathway for receptor ubiquitination requires interaction between the SH2 domain of c-Cbl and tyrosine ...
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The role of SH3BP2 in the pathophysiology of cherubism
... homology domain; PR: proline-rich domain; SH2: Src- homology 2 domain; Tyr: Tyrosine; Glu: Glutamic Acid; Asn: Asparagine; NS/ MGCLS: Noonan syndrome/multiple giant-cell lesion ...
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The C-Terminal Repeat Domains of nsP3 from the Old World Alphaviruses Bind Directly to G3BP
... the proline-rich domain to G3BP-1, relative to the wt protein ...the proline-rich domain did not inhibit nsP3’s ability to form a complex with G3BP-1 in Vero ...the ...
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Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer’s disease
... second proline-rich domain (GST-721Δ) of the ADAM10 tail (Figure ...membrane-proximal proline-rich domain and the second proline stretch is ...
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Late Domain Function Identified in the Vesicular Stomatitis Virus M Protein by Use of Rhabdovirus-Retrovirus Chimeras
... FIG. 3. Enhancement of the budding activity of the M-GagN chimera by the addition of the Src membrane-binding signal. (A) Particle assembly and release by the SrcM-GagN protein were compared to those of the wild-type Gag ...
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The effect of proline on the network structure of major ampullate silks as inferred from their mechanical and optical properties
... the proline-rich (+Pro) or proline- deficient (–Pro) silk networks, both in the dry and in the hydrated ...of proline-rich network chains is shifted left to lower energies and is much ...
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Regulation of the transforming immortalized mammary protein and its homologs by auto-inhibition and tyrosine phosphorylation
... DH domain of Vav1 and its inhibitory helix as determined by ...DH domain structures that have been solved to date (Figure ...DH domain to prevent GTPase binding and ...
202
A Proline-Rich Region in the Zeste Protein Essential for Transvection and white Repression by Zeste1
... nucleotide sequence that predicts a H400Y change in effectively than z 1 and do not support transvection at Zeste (Table 1; Figure 3). This is between two glutamine- alanine-rich stretches (opa repeats) found in ...
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Alternatively spliced proline rich cassettes link WNK1 to aldosterone action
... a proline-rich region of WNK1 that contain PY motifs, which bind the E3 ubiquitin ligase ...increased proline-rich WNK1 isoform abundance in WT mice but did not alter WNK1 abundance in ...
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Oral Antimicrobial Peptides and Biological Control of Caries
... The amount of AMPs expressed in saliva varies between individuals. This has been previously demonstrated for alpha- and beta-defensins, histatin, and proline-rich pro- teins [6,22,23]. Our initial studies ...
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Free Energies, Transition Mechanisms, and Structural Characteristics of Proline-Rich Peptides.
... for proline, with equilibrium structures that are consistent with experimental ...on proline simula- tions, studies 115,120 suggest that changing these is unlikely to strongly impact the free energies and ...
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Characterization of the Proline-Rich Region of Murine Leukemia Virus Envelope Protein
... Our analysis of the role of the PRR in the MuLVs initially investigated the ability of the amphotropic PRR to functionally substitute for the shorter ecotropic PRR in the MoMuLV envelope protein. We constructed a ...
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The Role of Cathelicidins in the Innate Host Defenses of Mammals
... Both the porcine PR-39 and the bovine BMAP-28 have been characterized for biological activities on mammalian cells (Table 3). PR-39 is a peculiar peptide and may contribute to the innate defenses of pigs with multiple ...
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Dose Response Relationship between Dietary Polyphenols from Acorns and Parotid Gland Hypertrophy in Pigs
... high proline content and small size ...salivary proline rich proteins (PRPs) ancestral function in the maintenance of oral health at a basal level of mucoproteins secretion, increased by high tannins ...
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