Prolonged Survival
Mutations in histone modulators are associated with prolonged survival during azacitidine therapy
... With the advent of next-generation sequencing, new potential biomarkers are rapidly being incorporated into routine clinical practice and are likely to influence patient management and therapeutic decisions. Adverse ...
13
Infection of burkholderia cepacia induces homeostatic responses in the host for their prolonged survival: the microarray perspective
... In summary, our data is consistent with the interpretation that B. cepacia can manipulate A549 cells for its own advantage, allowing prolonged survival inside the harmless environmental niche of the ...
11
Accelerated Prion Replication in, but Prolonged Survival Times of, Prion-Infected CXCR3−/− Mice
... Prion diseases have a significant inflammatory component. Glia activation, which is associated with in- creased production of cytokines and chemokines, may play an important role in disease development. Among the ...
8
Challenges Associated With Prolonged Survival of Patients With Thalassemia: Transitioning From Childhood to Adulthood
... First, modification of the health care system to provide necessary medical attention for adult patients with thalassemia could be achieved by employing more thalassemia specialists and a[r] ...
6
Surgical resection of the primary tumor leads to prolonged survival in metastatic pancreatic neuroendocrine carcinoma
... group survival analysis for patients undergoing surgical treatment showed that the prognosis of patients with both primary and metastatic resection was significantly better than that of patients with only primary ...
11
Treatment change as a predictor of outcome among patients with classic chronic graft-versus-host disease
... of prolonged survival or a shorter time to resolution of chronic GVHD may be feasible for pivotal phase III studies, but ascertainment of these endpoints occurs too late to be useful for phase II ...
16
MiR-Score: A novel 6-microRNA signature that predicts survival outcomes in patients with malignant pleural mesothelioma
... in survival between histo- logical subtypes ...with prolonged survival in univariate logis- tic regression (Figure 3D), the miR-Score again outperformed single microRNAs with an OR of ...a ...
12
Metastasis of gastrointestinal stromal tumor to skeletal muscle: a case report
... In summary, we present an extremely rare case of skeletal muscle metastasis from a GIST. To the best of our know- ledge, there have been only three previously reported cases in the English literature of GIST ...
5
Rapid postoperative recurrence of a cranial multilobular tumor of bone in a young dog
... This case report indicates that although resection of MTBs is typically associated with a good prognosis, long disease-free intervals, and prolonged survival, malignant transformation of residual tumor ...
5
The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness
... Transforming growth factor- beta is a pluripotent cytokine with both pro- and counter-inflammatory effects depending on its environment and concentration [84]. At higher concentrations, TGF-β is reported to play an ...
10
Intramuscular transplantation of bone marrow cells prolongs the lifespan of SOD1G93A mice and modulates expression of prognosis biomarkers of the disease
... and prolonged survival when compared to the sham-injected mice, supporting the feasibility and efficacy of this type of cell transplantation as a promising therapeutic strat- egy for ...
12
New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy
... Abstract: Oncolytic viruses have demonstrated selective replication and killing of tumor cells. Different types of oncolytic viruses – adenoviruses, alphaviruses, herpes simplex viruses, Newcastle disease viruses, ...
18
Targeted deletion of CX3CR1 reveals a role for fractalkine in cardiac allograft rejection
... Ab prolonged heterotopic cardiac graft survival in ...significantly prolonged survival of completely MHC-mismatched car- diac grafts and essentially permanent engraftment of MHC class II ...
11
Impact of type 2 diabetes mellitus on short-term and long-term outcomes of patients with esophageal squamous cell cancer undergoing resection: a propensity score analysis
... with prolonged survival in patients with various types of cancer, including thyroid cancer [22], colorectal cancer [23], laryngeal squamous cell cancer [24], melanoma [25], and pancreatic cancer ...
9
Pre-infection physical exercise decreases mortality and stimulates neurogenesis in bacterial meningitis
... and lower corticosterone levels in runners compared to sedentary mice. Overall, the extent of the inflammatory and stress response to bacterial meningitis was de- creased by physical exercise. This observation is in ac- ...
10
In vitro activated and induced of T-lymphocyte cells to produce of TH-1 cytokines by Salmonella enterica serovar typhi
... in prolonged survival of the bacteria and characteristic features of cytokine and cellular immune responses in the patients with systemic infection [10], that explained and supports the high levels of IFN-γ ...
6
Immunomodulatory intervention in sepsis by multidrug resistant Pseudomonas aeruginosa with thalidomide: an experimental study
... The applied model of sepsis was lethal as documented by the absolute mortality rate of animal-controls. Results revealed a considerable benefit of thalidomide intake on survival after bacterial challenge (Figure ...
5
<p>CXCR4 antagonism in combination with IDO1 inhibition weakens immune suppression and inhibits tumor growth in mouse breast cancer bone metastases</p>
... BC cells can also weaken the immune attack by over- expressing IDO1, which can establish a CD8+ T-cell- hostile environment through metabolic routes. In clinical trials, some IDO1 inhibitors such as D1MT or epacadostat ...
8
Clinical outcomes in ALK rearranged lung adenocarcinomas according to ALK fusion variants
... The following clinicopathologic parameters were recorded: age, sex, smoking status [never smokers, for- mer smokers (quit smoking >1 year before diagno- sis), and current smokers], pack-year smoking history (defined ...
10
Gene therapy with tumor specific promoter mediated suicide gene plus IL 12 gene enhanced tumor inhibition and prolonged host survival in a murine model of Lewis lung carcinoma
... and survival curves were established (Figure ...significant survival advantage with the med- ian survival increase to 51 versus 36 days for AdCMVmIL- 12 alone-treated mice, 33 days for AdhTERTHRP ...
10