PROTEASOME INHIBITOR
The proteasome inhibitor MG132 reduces immobilization induced skeletal muscle atrophy in mice
... B inhibitor, has been shown to stimulate muscle regeneration after traumatic injury ...of proteasome inhibitors. Proteasome inhibitors have been shown to inhibit IBa degradation and pre- vent NFB ...
11
The Proteasome Inhibitor Velcade Enhances rather than Reduces Disease in Mouse Hepatitis Coronavirus-Infected Mice
... cellular proteasome for efficient infection in vitro. Hence, the proteasome inhibitor Velcade (bortezomib), a clinically approved anticancer drug, shown in an accompanying study ...the ...
6
The novel beta 2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells
... Proteasome inhibitor resistance is a challenge for myeloma ...2 proteasome activity. To improve proteasome inhibition in borte- zomib-resistant myeloma and to achieve more efficient UPR ...
11
BU 32: a novel proteasome inhibitor for breast cancer
... of proteasome inhibition on different markers varies by drug, cell line, and time point of analysis ...Bortezomib. Proteasome inhibitor-induced apoptosis has been described as p53 dependent ...to ...
13
Proteasome Inhibitor Carfilzomib Enhances the Anticancer Effect of Paclitaxel in MDA-MB-231 Breast Cancer Cells
... This study was aimed to determine the anticancer efficacy of the combination of paclitaxel, the standard treatment of breast cancer, and carfilzomib, which is a proteasome inhibitor, in[r] ...
8
Pancreatic Neuroendocrine Tumors Are Characterized by Loss of Noxa Expression that Can be Recovered by the Proteasome Inhibitor Bortezomib
... the proteasome inhibitor ...some inhibitor, ...the proteasome inhibitor, bortezomib, leading to caspase activation and cell death supports the use of such drugs for the treatment of ...
6
Enhanced Chemosensitivity to CPT-11 with Proteasome Inhibitor PS-341.pdf
... the proteasome inhibitor PS-341 and SN-38/CPT-11 may be mediated by regulation of the factors that control the cell cycle and/or through modulation of the factors that regulate the induction of ...
7
Management and outcomes of proteasome inhibitor associated chalazia and blepharitis: a case series
... prospective, randomized study conducted by the senior author of this manuscript found that hot compresses alone or in combination with tobramycin or tobramycin/ dexamethasone drops and ointment are all effective ...
8
Pentoxifylline and the proteasome inhibitor MG132 induce apoptosis in human leukemia U937 cells through a decrease in the expression of Bcl-2 and Bcl-XL and phosphorylation of p65
... phosphodiesterase inhibitor that in- hibits tumor necrosis factor (TNF) and leukotriene synthesis and reduces inflammation ...MG132 proteasome inhibitor is another drug that decreases NF- κB activity ...
13
Microarray Analysis of Induced Inflammatory Gene Changes with Doxorubicin and a Second-generation Proteasome Inhibitor in Human Triple Negative MDA_MB-231 Breast Cancer Cell Line
... second-generation proteasome inhibitor, carfilzomib, resulted in a decrease in gene expression for VCAM1, and that combining it with the first line TNBC chemotherapeutic agent, doxorubicin, seemed to ...
6
Early Steps in Herpes Simplex Virus Infection Blocked by a Proteasome Inhibitor
... 26S proteasome activity to promote viral entry, gene expression, replication, assembly, and ...The proteasome inhibitor bortezomib (also known as Velcade and PS-341) is a clinically effective ...
14
The resistance mechanisms of proteasome inhibitor bortezomib
... the proteasome results in perturbation of intracellular protein homeostasis by accumulation of the poly-ubiquitinated proteins, subsequently inducing cellular stress and ...Numerous proteasome inhibitors ...
9
Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy
... reversible inhibitor of the 26S proteas- ome that was first shown to exhibit antitumor properties in a panel of 60 cancer cell lines from the US National Cancer Institute ...The proteasome is an enzyme com- ...
9
A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo
... the proteasome specifically and shows broad-spec- trum activity by covalent and irreversible binding to the catalytic N-terminal threonine residues of immu- noinducible and constitutively active b ...active ...
10
Cohesin is required for expression of the estrogen receptor-alpha ( ESR1 ) gene
... utilized proteasome inhibitor bortezomib which also decreased the mRNA levels of ESR1 and several cohesin subunits as well as SMC3 and ERα protein ...of proteasome inhibitor treatment for ...
13
PubMedCentral-PMC4984620.pdf
... the proteasome inhibitor bortezomib has been shown to enhance transduction of both rAAV2 and rAAV8 vectors, resulting in in- creased transgene expression in both small- and large-animal models (43, 54, 55); ...
13
Efficacious proteasome/HDAC inhibitor combination therapy for primary effusion lymphoma
... the proteasome inhibitor, bortezomib (Btz), increased survival relative to that after treatment with ...(HDAC) inhibitor suberoylanilidehydroxamic acid (SAHA, also known as vorinostat) potently ...
14
Inhibition of Cellular Proteasome Activities Mediates HBX-Independent Hepatitis B Virus Replication In Vivo
... the proteasome complex may underlie the pleiotropic functions of ...a proteasome-dependent pathway in cell culture ...the proteasome inhibitor MLN-273 in two HBV mouse ...cellular ...
6
Weinkauf, Marc Oliver (2008): Untersuchung zur Proteasomenhemmung des Mantelzelllymphoms mittels Bortezomib unter besonderer Berücksichtigung proteinanalytischer Verfahren. Dissertation, LMU München: Medizinische Fakultät
... Dreyling; The proteasome inhibitor bortezomib (Velcade®) induces rapid alterations of cell cycle regulators in mantle cell lymphoma; Deutsche Gesellschaft für Hämatologie und Onkologie[r] ...
139
Hepatitis C Virus NS2 Protein Is Phosphorylated by the Protein Kinase CK2 and Targeted for Degradation to the Proteasome
... Protein stability and subcellular localization of GFP-tagged NS2. Since we could not exclude that the VSV-G tag had an effect on NS2 stability or its membrane association, we decided to replace this protein tag by ...
9