Protein Corona
Protein corona: a new approach for nanomedicine design
... Hence, protein–NP interaction should be carefully investigated to predict and control the fate of NPs or drug-loaded NPs, including systemic circulation, biodistribution, and ...of protein corona and ...
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Preparation of Core Shell Hybrid Materials by Producing a Protein Corona Around Magnetic Nanoparticles
... For the investigation of the influence of particle surface charge on the formation of the protein corona, MNP were coated with different materials (dextran (DEX), carboxymethyl-dextran (CMD), and ...
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<div>Effects of the protein corona on liposome–liposome and liposome–cell interactions</div>
... Abstract: A thorough understanding of interactions occurring at the interface between nanocarriers and biological systems is crucial to predict and interpret their biodistribution, targeting, and efficacy, and thus ...
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Nanoparticle-allergen interactions mediate human allergic responses: protein corona characterization and cellular responses
... for protein corona characterization, we were confident that AuNP-allergen conjugates had been ...more protein than we used in our study, making these methods impossible to use in our experimental ...
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<p>Amphiphilic nanogels: influence of surface hydrophobicity on protein corona, biocompatibility and cellular uptake</p>
... Amphiphilic NGs combine aspects from hydrophobic and hydrophilic surfaces in one single colloidal system. Thus, their protein interactions and biocompatibility are far less understood. It becomes obvious that ...
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Profiling the serum protein corona of fibrillar human islet amyloid polypeptide
... serum protein retention on the filter after four wash cycles ...of protein corona formation under flow; wherein IAPP amyloid captured on the sensor surface as large contiguous ‘plaques’ was able to ...
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Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity
... applications. Protein coronas created during the initial reaction with NPs can determine the subsequent immunological cascade, and protein coronas formed on NPs can either stimulate or mitigate the immune ...
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<p>A Protein Corona Adsorbed to a Bacterial Magnetosome Affects Its Cellular Uptake</p>
... natural protein – protein ...are protein-rich mem- brane organelles 53 so the interaction between magnetosomes and plasma occurs through natural protein – protein interac- ...be ...
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<p>MWCNT interactions with protein: surface-induced changes in protein adsorption and the impact of protein corona on cellular uptake and cytotoxicity</p>
... MWCNT protein corona on phagocytosis/endocytosis and macrophage activation, cells were pretreated with an actin barbed-end capping molecule, CytoD, to disrupt phagocytosis and endo- ...and protein ...
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The effect of the protein corona on the interaction between nanoparticles and lipid bilayers
... a protein corona (PC), composed of a hard (strongly bounded) and a soft (loosely associated) layers, which represents the real nano-interface interacting with the cellular membrane in ...
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Regulation of in vivo behavior of TAT-modified liposome by associated protein corona and avidity to tumor cells
... Results: While TAT peptides facilitate active endocytosis of the carriers, we observed that these peptides did not promote endosomal escape or enhanced intracellular availability of doxorubicin. Interestingly, ...
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Protein corona: implications for nanoparticle interactions with pulmonary cells
... PBS solution. The size, shape and monodispersity of the NPs were verified by transmission electron micros- copy. UV-Vis measurements were performed with an Ultro spec 2100 Pro (Amersham). The maximum absorption of Au NPs ...
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Nanoparticle-protein corona formation and immunotoxicity of zinc oxide nanoparticles
... adsorbed protein layer and this can have a potential impact on the immunotoxic potential of these ...a protein corona composed of cytosolic and cell membrane proteins which can be a result of direct ...
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... define protein corona formation and fate are chemical composition, shape, curvature, surface functionalisation and structure, porosity, crystallinity, heterogeneity, roughness, and ...
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Physicochemical Characterization of FRET-labelled Chitosan Nanocapsules and Model Degradation Studies
... DiI. This was accompanied by a decrease in count rate and decrease in turbidity. On the other hand, physical blends of NCs loaded with either DiO or DiI under an identical treatment, first increased in FRET index and ...
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<p>Silica Nanocapsules with Different Sizes and Physicochemical Properties as Suitable Nanocarriers for Uptake in T-Cells</p>
... the protein corona study revealed that both protein corona and medium containing serum were able to lower the toxicity of SiNCs, leading to improved viability; however, these conditions ...
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Altered characteristics of silica nanoparticles in bovine and human serum: the importance of nanomaterial characterization prior to its toxicological evaluation
... this case the particles size was different than in the case when these procedures were not applied. Too long/fast particles centrifugation, too many washing steps or too long sonication caused the aggregation of the ...
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<p>Protein–Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles</p>
... vivo protein – NP interaction, termed “ protein ...a protein corona is an intricate process involving complex kinetics and dynamics between the two interacting ...in corona proteins ...
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<p>Tuning the surface coating of IONs toward efficient sonochemical tethering and sustained liberation of topoisomerase II poisons</p>
... as protein corona) on the IONs ...extensive protein corona, surface coating with POES and PVP is capable to markedly inhibit this ...formed corona pattern similar to bare ...of ...
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Changes in Optical Properties of Plasmonic Nanoparticles in Cellular Environments are Modulated by Nanoparticle PEGylation and Serum Conditions
... the protein corona formed on the NP surface as well as the cellular uptake of NPs [29, 31, ...the protein corona formed on the NP surface [43]. The protein corona of anionic NPs ...
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