protein modifications
Brain ureido degenerative protein modifications are associated with neuroinflammation and proteinopathy in Alzheimer’s disease with cerebrovascular disease
... degenerative protein modifications (DPMs) are associated with the apparition and progression of dementia, and at the same time, Alzheimer ’ s disease with cerebrovascular disease (AD + CVD) is the most ...
12
Detection of glycosylation and iron binding protein modifications using Raman spectroscopy
... From the loadings plots of PC1 (Fig. 4B) the main peaks of variance are observed to occur at ∼ 850, 1000 and 1600 cm −1 . Intense peaks in these regions are also frequently assigned to tyrosine, tryptophan and ...
8
Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling
... of protein modifications in biological ...Intriguingly, protein N-deamidation can be promoted by microenvironmental factors such pH and oxidative stress [178], as well as pro- tein interactions with ...
22
The role of protein modifications in senescence of freeze-dried Acetobacter senegalensis during storage
... whether protein insolubility which is observed in many aging processes (as well as in the present study) is also responsible for the death of bac- terial cells into VBNC ...between protein oxidation and ...
16
Towards Exhaustive Event Extraction for Protein Modifications
... of protein modifications in PubMed is extremely skewed, random sampling would recover almost solely instances of major types such as ...term protein processing, post-translational for mentions of ...
10
Detection of glycosylation and iron binding protein modifications using Raman spectroscopy
... transferrin Raman spectra. The weaker holoF peak may be due to the fact that the binding site for iron is buried inside the core of the ferritin molecule and may suppress the intensity of the peaks arising from the Fe-O ...
19
Pressure support ventilation attenuates ventilator induced protein modifications in the diaphragm
... in protein synthesis. Moreover, in con- trast to CMV, modifications in protein metabolism were not affected by PSV ...of protein turnover. In addition, because CMV decreased protein ...
9
Developing deeper understanding of cooking-induced protein modifications in lamb using a proteomic approach
... a protein band above 600 kDa using SDS-PAGE and LC-MS/MS (Wu et ...the protein identification results (Supplementary data ...the protein inference issue in shotgun proteomics (Nesvizhskii & ...
187
Systematic analysis of the intersection of disease mutations with protein modifications
... bound protein 10 (T422 M), found in three tumors, have been detected by mass spectrometry without functional characterization, forming a candidate set for further ...
10
N- and O-glycan cell surface protein modifications associated with cellular senescence and human aging
... The cell surface is covered with various glycoproteins, which play crucial roles in biological functions such as cell–cell adhesion, maintenance of protein structure, and molecular recognition. Dynamic changes in ...
11
Discovering human protein diversity
... the protein modifications observed and the frequency of each in the 1,000 samples ...27 protein modifications (20 posttranslational modifications and 7 point mutations) were detected, ...
8
PubMed Scale Event Extraction for Post Translational Modifications, Epigenetics and Protein Structural Relations
... on protein modifications is avail- able in general-purpose protein databases such as UniProt, and there are also a number of dedicated database resources covering such protein modifica- tions ...
9
A comprehensive resource for integrating and displaying protein post translational modifications
... known protein modifications, as well as the putative protein modifications predicted by a series of accurately computational tools ...for protein post-translational modifica- tions, ...
9
Studies of protein post translational modifications using high resolution tandem mass spectrometry
... studying protein interactions has been used successfully for many years; 221-224 however, not until 2000, was the idea of combining cross- linking and mass spectrometry (MS) as a tool to study protein ...
306
IN VITRO ANTI ARTHRITIC ACTIVITY OF METHANOLIC EXTRACTS OF ALLIUM SATIVUM
... In- vitro anti- arthritic activity was carried out as per the method of Yogesh Shivhare et.al with major modifications. [8] The reaction mixture 0.5ml consisted of 0.45ml bovine serum albumin (5%aqueous solution) ...
5
Modifications of myelin basic protein in DM20 transgenic mice are similar to those in myelin basic protein from multiple sclerosis
... In an earlier mainly morphological study (3) we reported that transgenic mice containing 70 copies of the transgene repre- sented a good model for spontaneous demyelination. In the present manuscript we describe detailed ...
11
Proteomic Analysis of Ubiquitin-Like Posttranslational Modifications Induced by the Adenovirus E4-ORF3 Protein
... uitin-like modifications induced during the early phase of Ad in- fection by the E4-ORF3 ...E4-ORF3 protein predominantly induces SUMO2/3 conju- gation of Mre11 and Nbs1 ...
12
Alzheimer’s disease hypothesis and related therapies
... Extracellular deposits of Aβ peptides as senile plaques, intraneuronal neurofibrillary tangles (NFTs), and large- scale neuronal loss were the main pathological features of AD. Thus, Aβ peptides have long been viewed as ...
7
Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis
... K protein specific antibody, re- ...K protein IP samples yielding a set of 178 proteins (Additional file 7: Table S6) that were represented by at least two peptides and further referenced as K protein’s ...
7
Overview of the Epigenetics and Post translational Modifications (EPI) task of BioNLP Shared Task 2011
... Table 7 summarizes the core task results. While all systems show notably higher performance than for the full task, high-ranking participants focusing on the core task gain most dramatically, with the FAUST system core ...
10