Protein-protein Interactions, Protein -DNA Interactions, DNA Replication and DNA Damage Repair
Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage
... The DNA damage response pathways are critical mechanisms of tumor suppression, as these pathways prevent accumulation of cells with oncogenic ...the DNA repair pathways are insufficient to ...
5
Stimulation of Replication Template-Switching by DNA-Protein Crosslinks
... of DNA damage, such as ionizing radiation and by several chemotherapeutic agents, or by endogenous DNA damage caused by reactive oxygen or nitrogen species or reactions with natural metabolic ...
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Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes
... TMZ alone (5mg/kg in Ora-Plus (Perrigo) via oral gavage five days/week) (LKT Laboratories), BAP2 alone (20 mg/kg via intraperitoneal injection in 5 % DMSO / 65 % 1,2-propanediol / 30 % saline five days/week), or local ...
17
The role of ChlR1 in DNA replication, DNA damage repair and cohesion establishment
... in DNA damage repair and cancer development is the association of FHL2 with BRCA1 ...in DNA damage ...oxidative DNA damage and double strand break repair through HR ...
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Phosphorylation of FtsZ and FtsA by a DNA Damage-Responsive Ser/Thr Protein Kinase Affects Their Functional Interactions in Deinococcus radiodurans
... a DNA damage-responsive protein kinase (RqkA) could inhibit their interactions, which can arrest cell division progression until the damaged DNA is ...from DNA damage and ...
18
Hepatitis B virus X protein interacts with a probable cellular DNA repair protein.
... a protein that binds to damaged DNA and that may represent the defective protein in XP group E patients (15, ...the protein (XPE-binding factor) from human ...excision repair pathway. ...
8
Geminivirus C3 Protein: Replication Enhancement and Protein Interactions
... 3. Replication enhancement activities of mutated C3 ...viral DNA accumulation was quantified on DNA gel blots by phosphorimage ...Relative replication activity was calculated as the ratio of ...
11
Affinity Purification of an Archaeal DNA Replication Protein Network
... chromosomal DNA replication machinery, is composed of subcomplexes that separate the duplex DNA, prime and synthesize DNA, mature and ligate Okazaki fragments, and facilitate and stabilize ...
10
Bovine papillomavirus E1 protein binds specifically DNA polymerase alpha but not replication protein A.
... BPV DNA synthesis in ...BPV DNA replication as efficiently as cell extracts from permissive cells ...of DNA synthesis obtained with equal amounts of similarly prepared extracts supplemented ...
10
Common determinants in DNA melting and helicase-catalysed DNA unwinding by papillomavirus replication protein E1
... of DNA melting and helicase unwinding in BPV E1 based on the common requirement for amino acids in a non-specific DNA binding ...of DNA in a central channel is considered key in explaining the ...
12
Review on DNA damage, repair and DNA sequencing
... usage, protein alignments use a substitution matrix to assign scores to amino-acid matches or mismatches, and a gap penalty for matching an amino acid in one sequence to a gap in the ...other. DNA and RNA ...
6
Functional Interaction between Epstein-Barr Virus Replication Protein Zta and Host DNA Damage Response Protein 53BP1
... viral replication. The switch between latency and replication is governed by the action of a multifunctional viral protein Zta (also called BZLF1, ZEBRA, and ...host DNA damage ...
7
Candida albicans RFX2 Encodes a DNA Binding Protein Involved in DNA Damage Responses, Morphogenesis, and Virulence
... through interactions with a variety of DNA binding ...to DNA damage re- sponse ...another DNA binding protein that targets TUP1 (6, 21, 34, ...
13
Stretching and immobilization of DNA for studies of protein–DNA interactions at the single molecule level
... of DNA for DNAP while RNAP catalyzes the addition of NTP to the growing chain of RNA; and (2) DNAP requires a primer (a short piece of ssDNA annealed to the template strand) to initiate the synthesis while RNAP ...
17
DNA Replication and Repair
... Upon DNA damage or other stress, various pathways will lead to the dissociation of the p53 and mdm2 ...allow repair and survival of the cell or apoptosis to discard the damage ...
13
Structural alteration of DNA induced by viral protein R of HIV 1 triggers the DNA damage response
... of DNA could induce both DDR activation and DSB ...creating DNA breaks ...other DNA structure modifica- tion factors such as Topo2, structure-specific nucleases including SLX4-Mus81/Eme1, and ...
25
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA
... oxoguanine DNA glycosylase 1 (hOgg1) ...during replication, causing G:C3T:A transversion mutations. Interrogation of DNA by hOgg1 to locate oxoG residues is made difficult not only by the vast excess ...
7
Adeno-Associated Virus Replication Induces a DNA Damage Response Coordinated by DNA-Dependent Protein Kinase
... AAV, DNA-PK has been previously impli- cated in the cellular response to infection by a number of other viruses ...subvert DNA-PK repair func- tions, such as the Tax oncoprotein of human T-cell ...
10
DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease
... by DNA-PK to cellular death machinery (reviewed in [81]). DNA-PK is also involved in regulating the activities of RNA polymerase I and II via phosphorylation (reviewed in ...of DNA-PK that are ...
8
Interdomain interactions of the transactive response DNA binding protein 43 kDa (TDP-43)
... mM EDTA, 1 mM DTT, pH 8.0, for final purification by IX (Figure 13E). HT-NR eluted between 250-350 mM NaCl and the most concentrated samples were pooled and stored for later use. Figure 13F shows the final purified HT-NR ...
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