Pulmonary surfactant
Engineering novel complement activity into a pulmonary surfactant protein
... Complement neutralises invading pathogens, stimulates inflammatory and adaptive immune responses and targets non- or altered-self structures for clearance. In the classical and lectin activation pathways it is initiated ...
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The effect of titanium dioxide nanoparticles on pulmonary surfactant function and ultrastructure
... the pulmonary surfactant layer that covers the entire alveolar ...region. Surfactant decreases the surface tension at the air-liquid interface and thereby prevents alveolar col- ...specific ...
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Tumor necrosis factor alpha inhibits expression of pulmonary surfactant protein
... of pulmonary surfactant proteins SP-A and SP-B in human pulmonary adenocarcinoma cell ...the pulmonary adenocarcinoma cell line, H441-4, was concentration and time ...
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Effects of Maternal Protein Restriction on the Pulmonary Surfactant System during the Early Life and Adulthood
... the pulmonary system (Mestan & Steinhorn, 2011; Real et ...the pulmonary surfactant; a lipid-protein mixture coats the inside of the lung and eases the lung expansion during respiration (West, ...
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Maintenance of human amnion epithelial cell phenotype in pulmonary surfactant
... lack pulmonary surfactant; a lipoprotein complex produced by type II alveolar epithelial cells [1] that reduces surface tension at the air-to-fluid ...exogenous surfactant (purified from animals and ...
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Dihydrotestosterone Inhibits Fetal Rabbit Pulmonary Surfactant Production
... fetal pulmonary surfactant production is under hormonal ...control. Pulmonary surfactant was measured as the saturated phosphatidylcholine/sphingomyelin ratio (SPC/S) in the lung lavage of ...
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The Biophysical Alterations to Pulmonary Surfactant during Lung Injury
... bodies’ surfactant biophysical function on the CSD, providing an in-depth assessment of adsorption and surface tension reduction during surface area ...body surfactant isolated from cell culture (Hobi et ...
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The Porcine Pulmonary Surfactant Protein A (pSP A) Immunogenicity Evaluation in the Murine Model
... Alveolar type II cells produce surfactant protein A, SP-A. This protein belongs to a group of soluble humoral pat- tern recognition receptors, called collectins, which mod- ulate the immune response to ...
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ACCELERATED PULMONARY SURFACTANT AFTER INTRAUTERINE INFECTION IN THE FETAL RABBIT
... The lungs of infected litters had increased low pressure stability and distensibility with decreased surface.. tension upon compression, and resembled 29- to.[r] ...
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Pulmonary surfactant and its apoproteins
... At all stages in the movement of surfactant lipids through this "alveolar cycle," with the possible exception of the interfacial monolayer itself, the surfactant lipids are associated wi[r] ...
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Thyroid hormone stimulation of phosphatidylcholine synthesis in cultured fetal rabbit lung
... To investigate the mechanism of thyroid hormone action on pulmonary surfactant synthesis, we characterized the effect of triiodothyronine on phosphatidylcholine synthesis in cultured fet[r] ...
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... supplementary pulmonary surfactant (PS) for the prevention of RDS has been attempted in both animal and human stud- ies [, ], and some of them illustrated this method has a signifi cant role in ...
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In vivo clearance of surfactant lipids during acute pulmonary inflammation.
... the pulmonary surfactant system, including decreased total surfactant levels, have been implicated in the pathophysiology of acute lung ...that surfactant levels are decreased in the inflamed, ...
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Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
... in pulmonary surfactant and lipid homeostasis [4], innate immunity [3], regulation of cel- lular clearance as well as inflammatory and immune responses ...
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Respirable antisense oligonucleotides: a new drug class for respiratory disease
... in pulmonary surfactant, and, because of the markedly different target properties of mRNA and proteins, they can have very long durations of effect compared with traditional drugs targeting the protein of ...
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Improved Neonatal Survival Following Multiple Doses of Bovine Surfactant in Very Premature Neonates at Risk for Respiratory Distress Syndrome
... Pediatrics 1991;88:10-18; pulmonary surfactant, bovine surfactant, respiratory distress syndrome, neonatal mor-.. tality, prematurity, bronchopulmonary dysplasia, hyaline membrane diseas[r] ...
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120 kD surface glycoprotein of Pneumocystis carinii is a ligand for surfactant protein A
... internalized or degraded by the P. carinii organism. Furthermore, SP-A binding to P. carinii is time- and calcium-dependent and is competitively inhibited by mannosyl albumin. In the absence of calcium or the presence of ...
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Cholesterol-Mediated Dysfunction of Surfactant Effects of Surfactant Protein-A and Diet-Induced Hypercholesterolemia
... their pulmonary surfactant system. As noted above, surfactant is a lipoprotein complex found within alveoli and its main purpose is to reduce surface tensions within the ...lungs. Surfactant ...
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Distinct compartmentalization of SP-A and SP-D in the vasculature and lungs of patients with idiopathic pulmonary fibrosis
... The pulmonary surfactant consists of phospholipids, mainly dipalmitoyl phosphatidylcholine (DPPC), surfac- tant protein (SP)-A, SP-B, SP-C, and ...pathic pulmonary fibrosis (IPF) ...
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Alterations in pulmonary surface active lipids during exposure to increased oxygen tension
... Our purpose in the present experiment was to induce changes in pulmonary surface tension in dogs by exposure to increased oxygen tension, to remove pulmonary surfactant by endobronchial [r] ...
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