Purinergic Receptors
Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis
... the purinergic receptors P2Y12R and P2X7R as potential targets for PET tracer development and subsequent PET imaging in order to evaluate the dynamics of microglia status in ...
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Identification of ionotrophic purinergic receptors in Huh 7 cells and their response towards structural proteins of HCV genotype 3a
... of Purinergic recep- tors [23]. Purinergic receptors are classified into two main types, P1 and P2 ...P2 receptors are further classified into two major types: P2X (ionotropic), and P2Y ...P2X ...
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Crosstalk between purinergic receptors and lipid mediators in leishmaniasis
... of purinergic receptors during infection by ...P2Y4 receptors have its expression upregulated and increased levels of uridine triphosphate (UTP) nucleotide into the extracel- lular environment during ...
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Expression of P2 Purinergic Receptors in Mesenchymal Stem Cells and their Roles in Extracellular Nucleotide Regulation of Cell Functions.
... paracrine purinergic signalling via the P2 family of purinergic receptors on the cell ...P2 receptors have been defined, namely, P2X and P2Y (Ralevic and Burnstock, ...P2X receptors ...
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Adenosine Receptors Machinery and Purinergic Receptors in Rat Primary Skeletal Muscle Cells
... adenosine receptors, which are divided into A 1 , A 2A , A 2B and A 3 adenosine receptors based on pharmacology and coupling to cAMP ...of receptors is P2Y receptors, which are divided into ...
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Targetable purinergic receptors P2Y12 and A2b antagonistically regulate bladder function
... Deletion of the P2Y 12 or A2b receptor also results in significant remodeling of BSM. Our data indi- cate that proliferation seems unchanged in these bladders; however, intriguingly, there were significant differences in ...
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Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone
... both the lens and optic disk were analyzed using a pseudorandom sampling technique (see Materials and Methods), and the number of mitotic profiles/100 m length of the retina was determined (Fig. 9B). Embryos exposed to ...
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Characterization of recombinant mouse ecto-5'-nucleotidase
... While ATP stimulates nociception, adenosine produces the opposite effect. The first antinociceptive effect of adenosine was observed by Vapaatalo, et al. in 1975 when they systemically treated rats with the adenosine ...
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Implications of purinergic receptor-mediated intracellular calcium transients in neural differentiation
... Purinergic receptors participate, in almost every cell type, in controlling metabolic activities and many physiological functions including signal transmission, proliferation and ...P2Y receptors ...
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Purinergic signalling in skin
... Purinergic receptors are classified into two groups: P I receptors are selective for adenosine and P2 receptors are selective for adenosine 5 ’-triphosphate (ATP) and adenosine 5 ’-diphosphate ...
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Apical membrane P2Y4 purinergic receptor controls K+ secretion by strial marginal cell epithelium
... Those cells were derived from guinea pig, the responses were monophasic and UTP was not tested as agonist. The apparent absence of desensitization (Fig. 4) was a sur- prising finding in view of reports of rapid ...
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Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration
... through purinergic receptors contribute to T cell activation at the immune synapse that T cells form with ...and purinergic signaling for their migration to ...P2X4 receptors near the front of ...
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P2 purinergic receptor agonists inhibit the growth of androgen independent prostate carcinoma cells
... membrane receptors that may transduce a growth inhibitory ...P2-purinergic receptors linked to phospholipase C, and that agonists of this receptor are markedly growth ...
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Immunogold electron microscopic evidence of in situ formation of homo and heteromeric purinergic adenosine A1 and P2Y2 receptors in rat brain
... Background: Purines such as adenosine and ATP are now generally recognized as the regulators of many physiological functions, such as neurotransmission, pain, cardiac function, and immune responses. Purines exert their ...
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Molecular and cellular mechanisms of nociception in equine laminitis: purinergic P2X receptors expression and distribution
... P2X receptor expression and function in peripheral nerve has been extensively studied in other species (for review see Dunn et al. 2001) and P2X2 and P2X3 receptor subtype immunoreactivity has been documented in ...
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Walenta, Lena (2018): Mechanisms of sterile inflammation in the testis. Dissertation, LMU München: Fakultät für Biologie
... could not be detected in the supernatant of ATP-treated HTPCs suggesting either that release required a certain, missing stimulus or that released amounts were still below detection limit. In this context, future ...
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Purinergic signalling in bone cells
... The P2Yi receptor is a receptor activated by adenine nucleotides (ADP and ATP), but not by uridine nucleotides (uridine 5’-diphosphate (UDP) and UTP). ADP is the most potent naturally occurring agonist, and whether ATP ...
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Purinergic signalling in bone
... P2X7 receptors are involved in ...P2X7 receptors are absolutely required for fusion of osteo- clasts due to P2X7 receptor-dependent release of ATP which is then broken down to adenosine with the subsequent ...
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Purinergic signalling in the urinary tract
... These receptors are localised on long slender cells in the prostate stroma, which also stain for smooth muscle myosin, confirming that they are smooth muscle ...the purinergic synergism is largely mediated ...
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The role of purinergic signalling in the musculoskeletal system
... role purinergic signalling in the musculoskeletal system has increased significantly in the past twenty ...that purinergic signalling also exerts some positive effects on bone cells, it is likely that a ...
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