Raf-1
Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy
... Since Raf-1 is an upstream regulator of MEK/ERK sig- naling, we next examined whether COPS3 plays a regula- tory role in this signaling ...of Raf-1 in both 143B and HOS cells ...of ...
12
Original Article Overexpression of Raf-1 and ERK1/2 in sacral chordoma and association with tumor recurrence
... that Raf-1 was significantly related to promoting tumor cell proliferation and invasion [25, ...of Raf-1 in epithelial cells affected the expression of genes which were involved in promoting ...
7
The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice
... There is a strong correlation between sidestream smoke exposure and the inflammatory responses. Sidestream smoke induces a dose-response in the systemic inflamma- tory cytokine production and oxidative stress [34]. Reac- ...
10
Activated Raf 1 causes growth arrest in human small cell lung cancer cells
... the raf-MEK mitogen-activated pro- tein kinases (MAPK) are associated with biological conse- quences that are unique from other ...of raf activation in small cell lung cancer cells was determined by ...
8
Raf-1 kinase targets GA-binding protein in transcriptional regulation of the human immunodeficiency virus type 1 promoter.
... Activated Raf-1 kinase synergizes with GABP in stimulating the HIV-1 promoter ...activated Raf-1 was capable of cooperating with GABP in transcriptional ac- tivation, NIH 3T3 cells were ...
9
Both the Polycythemia- and Anemia-Inducing Strains of Friend Spleen Focus-Forming Virus Induce Constitutive Activation of the Raf-1/Mitogen-Activated Protein Kinase Signal Transduction Pathway
... activates Raf-1, MEK and mitogen-activated protein (MAP) kinase, the downstream components of the Raf-1/MAP kinase ...of Raf-1 by using antisense oligonucleotides led to a ...
7
Viral Oncolysis That Targets Raf-1 Signaling Control of Nuclear Transport
... human Raf-1; rabbit polyclonal antibody (p␣-ERK) recognizing the ERK1/2 proteins, and mouse monoclonal antibody (m␣-P-ERK) recognizing their phos- phorylated ...
10
Inhibitory effects of H-Ras/Raf-1-binding affibody molecules on synovial cell function
... or Raf-1 could inhibit the production of ...or Raf-1 can inhibit inflammatory mediators or proteases, such as IL-6, PGE2, and MMP-3, which are crucial to RA ...
9
Constitutive Modulation of Raf-1 Protein Kinase is Associated with Differential Gene Expression of Several Known and Unknown Genes
... Human tumor cells transfected with expression vector (pcDNA3) containing the entire coding domain of human c-raf- 1 cDNA in the antisense orientation (PCI-06A-Raf (AS)) or a portion of c[r] ...
12
Modulation of Tumor Necrosis Factor by Raf-1 Inhibitor as a Potential Suppressor of Hepatocellular Carcinoma
... Noteworthy, Raf-1 activating MAPKs signaling has been found to play essential role in evaluation of HCC via activating of cellular machinery processes such as autophagy ...Additionally, Raf-1 ...
8
Cardiac specific disruption of the c raf 1 gene induces cardiac dysfunction and apoptosis
... The Raf/MEK/extracellular signal–regulated kinase (ERK) signaling pathway regulates diverse cellular pro- cesses such as proliferation, differentiation, and apoptosis and is implicated as an important contributor ...
8
Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells
... the Raf/MEK/ERK pathway in MCF-7 cells and higher levels of active ERK are detected in MCF7/DoxR cells than in drug sensitive MCF-7 ...∆ Raf- 1(CA) ...∆ Raf-1(CA) cells display ...
17
The Ras-Raf pathway is activated in human immunodeficiency virus-infected monocytes and particpates in the activation of NF-kappa B.
... of Raf (Raf BXB) which was cotransfected with reporter genes into U937 ...active Raf-1 kinase (Raf BXB) induced a fivefold increase in the transcriptional activity of an NF- k ...
7
Plasma Membrane-Targeted Raf Kinase Activates NF-κB and Human Immunodeficiency Virus Type 1 Replication in T Lymphocytes
... with Raf at the plasma membrane, it remains controversial whether this interaction is sufficient to achieve maximal Raf ...of Raf, including the Ras-bind- ing ...of Raf activity by subcellular ...
7
Identification of Autosomal Regions Involved in Drosophila Raf Function
... HE Raf serine/threonine kinase is an essential ef- and is able to substitute for Draf for viability and signal fector, downstream of Ras, in mediating the trans- transduction in Drosophila (Ambrosio et ...Ras, ...
12
Drosophila-Raf Acts to Elaborate Dorsoventral Pattern in the Ectoderm of Developing Embryos
... and Shilo 1997). In Drosophila, D-Ras acts to positively regulate the It has been anticipated, but not previously shown, that activity of D-raf in Tor, Egfr, and Sevenless signaling path- D-raf acts as an ...
14
Oxidative stress activates extracellular signal regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats
... tors such as receptor tyrosine kinases and G protein–coupled receptors (18, 19). Activation of ERKs is also critical for the development of cardiac hypertrophy (16, 19). Stimulation of receptor tyrosine kinases often ...
10
Oncogene co-operation in keratinocytes
... the Raf-1, A -Raf and B-R af knockout mice strongly suggest that these proteins are non- redundant and serve distinct functions ( Pritchard et al, 1996; Wojnowski et al, 1997; Wojnowski et al, ...
280
Cellular Splicing Factor RAF-2p48/NPI-5/BAT1/UAP56 Interacts with the Influenza Virus Nucleoprotein and Enhances Viral RNA Synthesis
... Since the systems described above are dependent on endog- enous vRNA templates, precise replication and transcription mechanisms including those for initiation reactions are difficult to assess. To address this issue, we ...
10
Modulation of Gq-Rho Signaling by the ERK MAPK Pathway Controls Locomotion in Caenorhabditis elegans
... Track waveform and radial locomotion assays were performed on 10 cm nematode growth medium (NGM) plates seeded with 400 ml of OP50 E. coli culture and spread with sterile glass beads. Bacterial lawns were grown at 37° ...
13