random X chromosome inactivation
A new model for random X chromosome inactivation
... X chromosome inactivation (XCI) is a process by which mammals reduce the number of active X chromosomes to one per diploid set of autosomes, thereby allowing for dosage equality between the ...
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Chromosome territories, X;Y translocation and Premature Ovarian Failure: is there a relationship?
... derivative chromosome could be related to skewed X inactivation ...derivative X carrying Yp sequences explain dif- ferent sexual phenotypes such as male, hermaphrodite or female because of the ...
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Mechanics and dynamics of X chromosome pairing at X inactivation
... Further insight and direct comparisons to known experimental results [4–6] are obtained by studying the dynamics of the probability distribution, F, of the normalized distance, ND, between the X chromosomes (ND is ...
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X Chromosome Inactivation in Opioid Addicted Women
... two X chromosomes which one of them in each somatic cell becomes inac- tivated very early in embryonic ...as X chromosome inactivation (XCI), leads to gene dosage equivalence between females ...
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X chromosome inactivation in the cycle of life
... active X chromosomes ensures that the concentration of the X-encoded activators is sufficient to initiate ...both X chromosomes could harbor epigenetic marks in a random fashion that are read ...
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Skewed X-chromosome inactivation in scleroderma.
... measurement method, a few percent to nearly one fifth of apparently healthy women display skewed (i.e., non-random) patterns of X-inactivation. Whereas, ratios in the range of 50-79 percent is ...
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Sexual dimorphism in autoimmunity
... Because X chromosome inactivation (XCI) occurs in early embryonic development, one of two X chromosomes in each cell is ...a random and permanent process and, as a result, most females ...
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A skewed view of X chromosome inactivation
... parental X active. While in most females the number of cells with either X being active is roughly equal, skewing of X chromosome inactivation is observed in a percentage of ...of ...
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COMPARATIVE STUDIES ON X-AUTOSOME TRANSLOCATIONS IN THE MOUSE. II. INACTIVATION OF AUTOSOMAL LOCI, SEGREGATION, AND MAPPING OF AUTOSOMAL BREAKPOINTS IN FIVE T(X;1)'S
... OHNO’S recent interpretation that random inactivation is possible only if “X chromosome material as a unit is preserved” by the translocation can be rejected on the basis of break[r] ...
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The Evolution of Genomic Imprinting and X Chromosome Inactivation in Mammals
... the X and the ...for X inactivation in placental ...imprinted X-inactivation and plat- ypus sex chromosome dosage compensation occur via a mechanism that is independent of the ...
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The random inactivation of the X chromosome carrying the defective gene responsible for X linked hyper IgM syndrome (X HIM) in female carriers of HIGM1
... We investigated the inactivation of the defective X chromosome in these female carriers by immunofluorescence staining, to identify the fraction of in vitro activated T cells expressing [r] ...
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Carrier detection in X linked severe combined immunodeficiency based on patterns of X chromosome inactivation
... whose X chromosome bearing the XSCID mutation was inactivated early in ...inactive X chromosomes and restriction fragment length polymorphisms to distinguish them, we have determined the lymphocyte ...
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Detailed analysis of X chromosome inactivation in a 49,XXXXX pentasomy
... females, X chromosome inactivation is usually random [32], consequently to which every X chro- mosome may be inactivated in a given cell during early development; once inactivated, this ...
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Mammalian X chromosome inactivation evolved as a dosage compensation mechanism for dosage sensitive genes on the X chromosome
... both X and autosomal genes. We computed the X/A expression ratio within each complex and we obtained the median of this ratio among all complexes present in a given tissue, as well as pooled for all tissues ...
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Unilateral retinitis pigmentosa and cone-rod dystrophy
... this being consistent with an autosomal recessive pattern of inheritance, and one instance where a parent was affected. In total, she found four familial cases out of a total of 24 unilat- eral cases. Our results are not ...
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The role of X chromosome inactivation in female predisposition to autoimmunity
... for X-inactivation skewing in altering this process, unless the skewing were virtually ...of X-linked autoantigens could play a role here, but this would require invoking a peripheral tolerizing ...
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Skewed X-chromosome inactivation in patients with esophageal carcinoma
... imbalanced inactivation of X chromosomes in female somatic cells, as usually demon- strated using peripheral blood sample, indicate an in- creased risk of malignant solid tumours development? To our ...
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The X chromosome and sex-specific effects in infectious disease susceptibility
... the X chromosome and X chromosome inactivation (XCI) ...one X chromosome is inactivated to bal- ance dosage of gene expression between XX females and XY ...the X ...
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Familial chromosomal translocation X; 22 associated with infertility and recurrent X mosaicism
... the X-chromosome inactivation assay for both mother and sister revealed a nonrandom X inactivation, they showed different ...translocated X-chromosome, the sister ...
7
6252.pdf
... Didion, Dr. Jeremy R. Wang, Dr. Jeremy B. Searle, Dr. Leonard McMillan, Dr. William Valdar and Dr. Fernando Pardo-Manuel de Villena. The aim of these experiments was to fine map Xce, investigate the haplotype diversity ...
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