Ras GTPase activating protein
Ras GTPase-Activating Protein Gap1 of the Homobasidiomycete Schizophyllum commune Regulates Hyphal Growth Orientation and Sexual Development
... a Ras GTPase-activating ...a Ras GTPase-activating protein, gap1, had been identified previously in a screen for differentially expressed genes in B-regulated development ...
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Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway
... cancer. Ras GTPase-activating protein SH3 domain-binding protein 1 (G3BP1), an essential Ras mediator, has been implicated in cancer development, including cell growth, motility, ...
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Ras GTPase-Activating Protein Regulation of Actin Cytoskeleton and Hyphal Polarity in Aspergillus nidulans
... a Ras GTPase-activating ...fluorescent protein shows cortical localization with strong predominance at the hyphal tips, we propose that GapA-mediated downregulation of Ras signaling at ...
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Hepatitis C Virus Co-Opts Ras-GTPase-Activating Protein-Binding Protein 1 for Its Genome Replication
... Reduction of G3BP1 levels reduces HCV replication and infection. Since G3BP1 is localized to HCV RCs, we wondered whether it modulates RC formation or viral RNA replication. To address this, we examined HCV replication ...
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Tfs1p, a Member of the PEBP Family, Inhibits the Ira2p but Not the Ira1p Ras GTPase-Activating Protein in Saccharomyces cerevisiae
... of Ras with an arginine (the finger) localized at the tip of a loop (the finger loop) joining two ␣-helices, thus stabilizing the transition state of the GTPase reaction and playing a crucial role in ...
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Conidial Morphogenesis and Septin-Mediated Plant Infection Require Smo1, a Ras GTPase-Activating Protein in Magnaporthe oryzae
... The conidial shape phenotype of Dsmo1 mutants suggested an effect on the distribution and organization of cytoskeletal components. We therefore visualized the distribution of mi- crotubules based on expression of the ...
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Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC)
... FK506-binding protein; GAP: GTPase activating protein; GEF: Guanine nucleotide exchange factor; GPCR: G protein-coupled receptor; HDAC: Histone deacetylase; HNSCC: Head and neck ...
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Lymphangioleiomyomatosis — a wolf in sheep’s clothing
... conserved GTPase-activating protein (GAP), and TSC1 encodes hamartin, which heterodimerizes with tuberin (49) and appears to be essential for its function (Figure ...a Ras homolog, is ...
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Purification and functional characterization of brain and recombinant chimaerin, a p21rac GTPase activating protein
... the GTPase activity of microinjected ras (Trahey and McCormick, ...with ras to regulate its function, pi 20 rasGAP also binds to two other proteins in the cell (Bouton et al, 1991 ; Ellis et al, ...
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RalA, a GTPase targeted by miR‑181a, promotes transformation and progression by activating the Ras‑related signaling pathway in chronic myelogenous leukemia
... are ras downstream signaling ...that Ras activation of RalA leads to engagement of multiple effector pathways (MAPK, ErbB, VEGF, mTOR, Wnt and PI3K‑Akt), which are closely correlated with CML pathogenesis ...
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Regulation and structure/function relationships of the Rac1 GTPase-activating protein, n-chimaerin
... by activating adenyl cyclase in the olfactory epithelium hence promoting electrical excitation of olfactory ...and Ras signalling pathway (Wu et a l, ...dependent protein kinase (PKA) which is ...
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‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC
... oligophrenin-like protein) is a GTPase-activating protein originally identified in avian cells, where it binds in an SH3 domain-dependent manner to the C-terminal domain of focal adhesion ...
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GTPase-Activating Proteins for Cdc42
... Cdc42 protein (33) is a member of the Rho subfamily of the Ras superfamily of GTPases, which act as molecular switches and regulate many cellular processes (1, ...and GTPase-activating ...
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Haas, Alexander (2008): Regulation of endocytosis and secretion by Rab GTPase activating proteins. Dissertation, LMU München: Fakultät für Biologie
... this protein family were identified in the human genome prior to this ...the Ras super-family not only one catalytic mechanism is used to hydrolyse ...
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Effects of lovastatin on breast cancer cells: a proteo metabonomic study
... Small GTPase-proteins are frequently discussed tar- gets of statins ...a protein implicated in the control of cell growth, apoptosis [40] and tumorigenesis ...of Ras-GTPase activating ...
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Hyphal Guidance and Invasive Growth in Candida albicans Require the Ras-Like GTPase Rsr1p and Its GTPase-Activating Protein Bud2p
... Indeed, Ras- and Rho-type GTPases are likely to be components of a general mechanism used for growth guidance in many eukaryotic cell ...example, Ras- and Rho-type GTPases mediate extracellular signals that ...
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Role of IQGAP3 in metastasis and epithelial–mesenchymal transition in human hepatocellular carcinoma
... motif-containing GTPase activating protein 3 (IQGAP3), a primary member of the IQGAP family and GTPase-activating protein, is located at ...by activating EGFR–ERK ...
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RPE phagocytic function declines in age related macular degeneration and is rescued by human umbilical tissue derived cells
... Rho GTPase activating protein 9; ATCC : American Type Culture Collection; ATP: adenosine triphosphate; BDNF: brain-derived neuro- trophic factor; CM: conditioned media; DMEM: Dulbecco’s modified ...
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Morphogenetic Circuitry Regulating Growth and Development in the Dimorphic Pathogen Penicillium marneffei
... Once a conidium has extended a primary germ tube, polarized growth continues along the pre-established axis to produce the highly polarized hyphal cell. Hyphae undergo cytokinesis without cellular division to become ...
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Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis
... Previous studies in mouse models reported changes in pre- synaptic release and region-dependent neural network ac- tivity dysfunction due to CLN3 deficiency, especially affecting GABAergic and glutamatergic transmission, ...
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